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김용석(Yong Seok Kim),황준영(Jun Young Hwang),안지현(Ji Hyun Ahn),김미경(Mi Kyung Kim),박준석(Jun Seok Park),최유신(Yoo Shin Choi),김범규(Beom Gyu Kim),박용검(Yong Gum Park),지경천(Kyung Chun Chi),이정효(Jung Hyo Lee),임현묵(Hyun Muc 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.6
Paragangliomas are rare tumors that arise from the extraadrenal chromaffin cells. We report here on a case of retroperitoneal paraganglioma in a 24-year-old young man. Abdomen CT and magnetic resonance imaging showed a hypervascular mass near the left ureter. He had not felt paroxysmal palpitation and his vital signs were within the normal range. An exploratory laparotomy revealed a 7.2×5.5 cm sized mass below the jejunum and near the aorta, and this mass had adhesion to the left ureter. It was histologically diagnosed with a paraganglioma after the surgical resection. Although there was an increase of blood pressure on palpation during surgery, the postoperative course was uneventful. When we consider the unusual locations and the associated operative risk, we should take care to rule out the possibility of a functional paraganglioma in the preoperative differential diagnosis of an abdominal mass.
위 종양에서 nm23 유전자 단백 및 P-glycoprotein 발현에 관한 면역조직화학적 연구
정시영,김미경,박언섭,유재형,박용검 중앙대학교 의과대학 의과학연구소 1996 中央醫大誌 Vol.21 No.1
Cancer cell metastasis and anti-cancer drug resistance of malignant tumors are basic problems in cancer eradication. The nm23 gene has been proposed to be a metastatic supressor gene and its down-regulation associated with metastasis or disease progression in some of the tumors. The P-glycoprotein, known as MDR gene product, is over-expressed in a various human cancers and related with multi-drug resistance. We investigated the expression pattern of nm23 gene product and P-glycoprotein in 47 cases of gastric adenocarcinoma according to tumor sites, differentiation, serosal invasion and lymph node metastasis by using immunohistochemical method. The nm23 gene product and P-glycoprotein were generally expressed in cytoplasm with granular pattern in tumor cells and in some of neighboring normal gastric mucosa. The overall expression rates of nm23 protein and P-glycoprotein, were 57% and 67%, respectively. The nm23 expression rates were inversely correlated with tumor cells differentiation. lymph node metastasis status and serosal invasion(P<0.05). The P-glycoprotein expression rates were not stastically correlated with other pathologic parameters such as tumor location, serosal extension, and lymph node metastasis except tumor cells differentiation. The results suggest that the down-regulation of nm23 protein might have a role of metastasis and invasion in gastric adenocarcinoma, meanwhile the overexpression of P-glycoprotein plays a role of intrinsic drug resistence of gastric adenocarcinoma resulting poor prognosis. A retrospective and prospective study The results suggest that the down-regulation of nm23 protein might have a role of metastasis and expression.