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염산/에탄올로 유도된 급성 위염 동물모델에서 십자화과 생즙 발효물의 위점막 보호 효과
박양규,조정휘,최진영,김영필,이상엽,박주헌,오홍근,Park, Yang-Gyu,Cho, Jeong-Hwi,Choi, Jinyoung,Kim, Youngpil,Lee, Sang-yeob,Park, Ju-Hun,Oh, Hong-Geun 한국식품영양학회 2021 韓國食品營養學會誌 Vol.34 No.5
In recent years, there has been an increase in the morbidity of gastritis in Korea due to lifestyle factors mostly changes in eating habits and stress. Gastritis is more likely to progress to gastric cancer, and therefore it is important to prevent and manage gastritis through lifestyle adjustment and treatment at an early stage. In this study, cabbage, which was found to be effective in gastritis, was mixed and fermented with other crucifer plants such as kale and broccoli to evaluate the overall efficacy of fermented brassica puree on alcoholic acute gastritis. Based on our results, fermented brassica puree alleviated gastric injury induced by 150 mM HCl/60% ethanol. In addition, it was confirmed that PGE<sub>2</sub>, a gastric mucosal protective factor, was increased, and other positive effects such as an increase of MUC1 and regulation of PKC were observed. The results of this study suggest that fermented brassica puree can relieve acute alcoholic gastritis by regulating PGE and the expression of MUC1, a gene related to mucus secretion, and activating PKC, which is related to mucosal cell activity.
유산균제제(Lactobacillus helveticus HY7801)의 경구 투여가 아토피 피부염 동물모델의 면역 반응 및 피부 개선에 미치는 효과
박양규,조정휘,최진영,김영필,유선정,김옥진,오홍근,Park, Yang-Gyu,Cho, Jeong-Hwi,Choi, Jinyoung,Kim, Youngpil,Yu, Seon-Jeong,Kim, Okjin,Oh, Hong-Geun 한국식품영양학회 2020 韓國食品營養學會誌 Vol.33 No.2
Probiotics improve the immune system. However, the effects of its lactic acid bacteria on atopic dermatitis relief and inflammation improvement is not fully understood. Recently, one of the probiotics, Lactobacillus helveticus HY7801 (HY7801), was found to have an anti-inflammatory effect. In this study, we investigated the effects of HY7801 on atopic dermatitis-induced animal models. After four weeks of oral administration, the group treated with HY7801 showed amelioration of the atopic dermatitis compared to the group receiving placebo. In the HY7801 treated group, the epidermal hyper-proliferation and collagen deposition were inhibited compared to the placebo group, and the secretion amount of the inflammatory factors, such as TNF-α, IL-4 were reduced. In conclusion, these results suggest that HY7801 acts as a functional probiotic via amelioration of the atopic dermatitis such as a decrease of epidermal hyper-proliferation, and collagen deposition and anti-inflammatory effects.
가상조직내 참여 구성원들간의 신뢰수준의 결정요인과 그 효과에 대한 연구
박양규(Park Yang Gyu),박경규(Park Gyeong Gyu),남기찬(Nam Gi Chan) 한국경영학회 2003 經營學硏究 Vol.32 No.5
Facing competitive and complicated business environment, companies are developing new and diverse organization forms to overcome risk and to maximize performance. Virtual organization nowadays is considered as one of representative forms enhancing organizations performance. Virtual organization is created through a line of core competency among participating firms based on diverse cooperation structure. This study investigates the determinants of success of virtual organization based on the concept of trust since trust is one of important factors minimizing individual participant’s opportunistic behavior and uncertainty. The proposed research model was tested with 115 questionnaires. The result shows that the proposed hypotheses with respect to four determinants, uniqueness of knowledge, linking of knowledge, shared emotional understanding, and communication openness were partially supported. Implication and interpretation are discussed with cases and results.
간헐파형 Doppler 심초음파도를 이용한 좌심실 수축기 기능의 평가지표
홍성욱 ( Hong Seong Ug ),김동훈 ( Kim Dong Hun ),박종철 ( Park Jong Cheol ),정진원 ( Jeong Jin Won ),박양규 ( Park Yang Gyu ),박옥규 ( Park Og Gyu ) 대한내과학회 1993 대한내과학회지 Vol.44 No.1
연구배경 : 심전도, 간접 경동맥파도, 심음도를 이용한 구혈전기와 좌심실 구혈시간의 비(PEPc/LVETc)를 좌심실 유출로의 간헐파형 Doppler 심초음파도를 이용한 수축기 기능지표들로의 대치 가능성을 검토하기 위하여 본 연구를 시행하였다. 방법 : 임상적으로 울혈성 심부전증 소견을 보인 확장성 심근중 환자 22명과 정상 대조군 21명에서 ATLUM 9 심초음파기를 사용하여 심첨 4방 또는 5방 단면도에서의 좌심실 유출로의 간헐파형 Doppler 심초음파도, 간점 경동맥파도, 심음도 및 심전도를 동시에 기록하여 계측한 비관혈적 좌삼실 수축기의 기능지표들에 대하여 비교관찰하였다. 결과 : 1) FVI는 PEPc/LVETc, 간헐파형 Doppler 심초음파도에서 측정한 구혈전기와 좌심실 구혈시간의 비(PEPd/LVETd)와 상호 매우 유의한 상관관계를 보였다(r=-0.66, p<0.01와 r=-0.72, p<0.01). 2) 심부전 환자군은 정상 대조군보다 PEPc/LVETc)(0.45±0.11와 0.33±0.05, p<0.01), PEPd/LVETd (0.44±0.08와 0.32±0.04, p<0.01)가 매우 유의하게 증가하였고, FVI (12.8±01.6와 14.1±2.1, p<0.05)는 감소하였다. 3) 심부전 환자에서 좌심실 수축기 기능의 총수치인 NISCORE는 PEPd/LVETd, FVI와 매우 유의한 상관관계를 보여(r=0.64, p<0.01와 r=-0.56, p<0.05), NISCORE가 높으면 높을수록 PEPd/LVETd는 증가하였고 FVI는 감소하였다. 결론 : 간접 경동맥파도를 이용한 PEPc/LVETc 대신 Doppler 심초음파도를 이용한 PEPd/LVETd와 FVI를 좌심실 수축기의 기능지표로 대치할 수 있을 뿐 아니라, 울혈성 심부전증의 중등도 평가에도 유용하리라 사료된다. Background : This study was performed to evaluate the clinical usefulness of systolic time intervals using pulsed Doppler echocardiogram in left ventricular outflow tract instead of those using ECG, phonocardiogram and indirect carotid arterial pulse tracing. Method : The pre-ejection period (PEPd), left ventricular ejection time (LVETd), the ratio of PEPd to LVETd (PEPd/LVETd), peak folw velocity (PFV), and flow velocity integral (FVI) using pulsed Doppler echocardiogram in left ventricular outflow tract were measured in 22 subjects with dilated cardiomyopathy and 21 normal subjects with average age of 50 (30~73) years. ECG, phonocardiongram, indirect carotid arterial pulse tracing, and pulsed Doppler echocardiogram in left ventricular outflow tract were recorded simultaneously with paper speed of 50~100mm/sec. The parame ters of the conventional systolic time intervals (PEPc, LVETc and PEPc/LVETc) were compared in two groups of the subjects. Result : PEPd/LVETd was significantly correlated with PEPc/LVETc and FVI (r=0.89, p<0.01 and r=-0.72, p<0.01), respectively. In subjects with heart failure, PEPc/LVETc and PEPd/LVETd were significantly increased (0.45±0.11 versus 0.33±0.05, p<0.01 and 0.44±0.08 versus 0.32±0.04, p<0.01) respectively but, FVI was significantly decreased, in comparison to the normal subjects (12.8±2.1 versus 14.1±2.1, p<0.05). Conclusion : In conclusion, systolic time intervals and FVI measured from pulsed Doppler echocardiogram seem to be more useful parameters for the evaluation of left ventricular systolic function than those measured from conventional indirect carotid arterial pulse tracing.