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박세호(SeHo Park),이영해(YoungHae Lee) 한국경영과학회 2011 한국경영과학회 학술대회논문집 Vol.2011 No.5
This paper studies how contract methods under revenue sharing alters the performance of a supply chain. The base model is a two echelon seasonal supply chain that has a supplier selling to a single retailer, with the assumption that external demand occurring at the customer is uncertain. In most of the previous research, the impact of revenue sharing on supply chain performance is investigated mostly for cases that the retailer has no contract method to purchase from a supplier. In this paper, we attempt to combine revenue sharing with several alternative contracts: buy-back contracts, quantity-flexibility contracts. Then, we investigate the impact of each of contract methods on supply chain performance.
Seho Park(박세호),Young Sin Ko(고영신),Ja Seung Koo(구자승),Joohyuk Sohn(손주혁),Seung Il Kim(김승일),Byeong-Woo Park(박병우) 대한종양외과학회 2015 Korean Journal of Clinical Oncology Vol.11 No.1
Purpose: This study aimed to compare expression of human epidermal growth factor receptor (HER) family and insulin-like growth factor- 1 receptor (IGF-1R) before and after targeted therapy in HER-2 positive breast cancers. Methods: Epidermal growth factor receptor (EGFR), HER-3, HER-4, and IGF-1R were immunohistochemically determined using pairwise archives tumor blocks of 28 patients received chemotherapy and HER-2 directed therapy between January 2007 and December 2011. Of them, 5 good responders achieved a pathologic complete response after neoadjuvant therapy and 23 poor responders experienced disease progression or metastasis even HER-2 targeted therapy. Expression of biomarkers was compared using chi-square test. Results: Stage II, III, and IV was 14 (50.0%), 11 (39.3%), and 3 (10.7%) patients, respectively. Hormone receptors-positive tumors were 15 (53.6%) patients and 9 (32.1%) patients received tyrosine kinase inhibitors with or without trastuzumab. Positive expression of initial EGFR, HER-3, HER-4, and IGF-1R was determined in 15 (53.6%), 11 (39.3%), 22 (78.6%), and 14 (50.0%) patients, respectively. Although there was no statistical significance, good responders showed a higher proportion of positive HER-3 expression. Among 23 poor responders, growth factor receptors family expression showed a trend of concordant results, however, unpredictively certain patients demonstrated discordant results between before and after targeted therapy. Conclusion: Unpredicted correlation of growth factor receptors family expression suggested that complex and personalized resistance mechanisms may be involved to HER-2 directed therapy. However, HER-3 expression might be associated with responsiveness to HER-2 targeted therapy. It would be important to develop diagnostic and therapeutic strategies for overcoming resistance to HER-2 targeted therapy.
고강도 열연강판의 구멍확장 시험 시 균열의 전파거동에 미치는 미세조직의 영향
박세호(Seho Park),변정국(Jungkuk Byun),도형협(Hyeonghyeop Do),정인상(Insang Chung) 한국자동차공학회 2011 한국자동차공학회 부문종합 학술대회 Vol.2011 No.5
Recently, advanced vehicle concepts and light-weight design of automobiles require improved steel grades with increased strength and formability. Especially, high strength hot-rolled steel sheets applied to chassis such as wheel, lower arm require high hole expansion ratio because of their complicated shapes in cold press processing. Aim of this study is to analyze the effects of microstructures on the crack propagation behavior during hole expansion which is used to estimate stretch-flangeability for steel sheets. For high strength steel sheets which had various microstructures and different components, hole expansion test were carried out and than analyzed the differences of the crack propagation behavior. As the result, it was conclusioned that formation of the 2nd fracture surface, low difference in hardness between the matrix and 2nd phase, excellent uniformity of the microstructures and a small number of the micro-voids led to excellent hole expansion ratio (HER).
박세호(SeHo Park),이영해(YoungHae Lee) 대한산업공학회 2011 대한산업공학회 춘계학술대회논문집 Vol.2011 No.5
This paper studies how contract methods under revenue sharing alters the performance of a supply chain. The base model is a two echelon seasonal supply chain that has a supplier selling to a single retailer, with the assumption that external demand occurring at the customer is uncertain. In most of the previous research, the impact of revenue sharing on supply chain performance is investigated mostly for cases that the retailer has no contract method to purchase from a supplier. In this paper, we attempt to combine revenue sharing with several alternative contracts: buy-back contracts, quantity-flexibility contracts. Then, we investigate the impact of each of contract methods on supply chain performance.