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초등학교 과학과 "간이 소화기 만들기" 실험의 개선에 관한 연구
고영신 ( Young Sin Ko ),김선경 ( Sun Kyoung Kim ),김세경 ( Se Kyong Kim ),고인자 ( In Ja Ko ) 서울교육대학교 초등교육연구원 2005 한국초등교육 Vol.15 No.2
초등학교 과학과 "간이 소화기 만들기" 실험의 개선에 관한 연구 A Study about Improvement of Experiment of "Making Portable Fire Extinguishers" on Elementary School Science Textbooks
Seho Park(박세호),Young Sin Ko(고영신),Ja Seung Koo(구자승),Joohyuk Sohn(손주혁),Seung Il Kim(김승일),Byeong-Woo Park(박병우) 대한종양외과학회 2015 Korean Journal of Clinical Oncology Vol.11 No.1
Purpose: This study aimed to compare expression of human epidermal growth factor receptor (HER) family and insulin-like growth factor- 1 receptor (IGF-1R) before and after targeted therapy in HER-2 positive breast cancers. Methods: Epidermal growth factor receptor (EGFR), HER-3, HER-4, and IGF-1R were immunohistochemically determined using pairwise archives tumor blocks of 28 patients received chemotherapy and HER-2 directed therapy between January 2007 and December 2011. Of them, 5 good responders achieved a pathologic complete response after neoadjuvant therapy and 23 poor responders experienced disease progression or metastasis even HER-2 targeted therapy. Expression of biomarkers was compared using chi-square test. Results: Stage II, III, and IV was 14 (50.0%), 11 (39.3%), and 3 (10.7%) patients, respectively. Hormone receptors-positive tumors were 15 (53.6%) patients and 9 (32.1%) patients received tyrosine kinase inhibitors with or without trastuzumab. Positive expression of initial EGFR, HER-3, HER-4, and IGF-1R was determined in 15 (53.6%), 11 (39.3%), 22 (78.6%), and 14 (50.0%) patients, respectively. Although there was no statistical significance, good responders showed a higher proportion of positive HER-3 expression. Among 23 poor responders, growth factor receptors family expression showed a trend of concordant results, however, unpredictively certain patients demonstrated discordant results between before and after targeted therapy. Conclusion: Unpredicted correlation of growth factor receptors family expression suggested that complex and personalized resistance mechanisms may be involved to HER-2 directed therapy. However, HER-3 expression might be associated with responsiveness to HER-2 targeted therapy. It would be important to develop diagnostic and therapeutic strategies for overcoming resistance to HER-2 targeted therapy.
돗돔(Stereolepis doederleini)의 식품성분
문수경 ( Soo Kyung Moon ),김인수 ( In Soo Kim ),고영신 ( Yeong Sin Ko ),박정희 ( Jeong Hee Park ),김금조 ( Geum Jo Kim ),정보영 ( Bo Young Jeong ) 한국수산과학회(구 한국수산학회) 2011 한국수산과학회지 Vol.44 No.5
The proximate, fatty acid and total amino acid compositions of striped jewfish Stereolepis doederleini muscle were studied. The proximate composition was: 76.4% moisture, 19.4% protein, 2.92% lipid, and 1.19% ash. The predominant total lipid fatty acids were 16:0 (18.7%), 18:1n-9 (16.5%), 22:6n-3 (16.0%), 16:1n-7 (8.53%), 20:5n-3 (7.97%) and 18:0 (5.34%). Glutamic acid (17.4%), lysine (10.6%), aspartic acid (10.4%) and leucine (8.27%) were the predominant amino acids in striped jewfish muscle. These food components of striped jewfish were similar to those of costal and reef dwelling fishes such as black rockfish, black sea bream and rock trout, which are common sliced raw fish in Korea. Therefore, these results suggest that striped jewfish may represent a new aquaculture fish species.
高永信 서울교육대학교 과학교육연구소 1990 科學과 數學敎育 論文集 Vol.16 No.-
本 硏究는 화학 분석 시험이라는 점토 성질 조사 시험방법을 사용하여 도자기, 내화물 뿐만아니라, 여러가지 신소재의 원료로 이용되는 점토를 성분 분석해 냄으로써 점토내의 H_2O, SiO_2, Al_2O_3 및 기타원소, 유기물, 불순물의 함량을 알아보고, 이 실험의 과정을 통해 얻은 지식을 '혼합물의 분리' 단원에서 효과적으로 活用할 수 있는 방법을 提示해 보도록 하겠다. This study aim's at investigating the content ratio of H_2O, SiO_2, impurities, organic matters, Al_2O_3, and some other element included in clay, which is widely used as the raw material of the ceramic ware, fireproof material and other new materials nowadays, through the chemical analysis of the property of clay and then applying the results of the study to the science education of "the separation of compound" in the second term of fourth grade in elementary school.