Prostaglandin E₂와 Indomethacin이 백서 치조골 내 Collagen과 Chondroitin Sulfate의 정량 변화에 미치는 영향

박세진,손병화,Park, Sei Jin,Sohn, Byung Wha 대한치과교정학회 1990 대한치과교정학회지 Vol.20 No.2

The alveolar bone remodeling is essential in tooth movement by orthodontic forces. The collagen and chondroitin sulfate are acting as an important roles in bone remodeling. This study was performed to measure out the quantity of the collagen and chondroitin sulfate in the alveolar bone of rats applied by experimental orthodontic forces. The 150 Sprague-Dawley male rats were divided into the $PGE_2$ treated group, indomethacin treated group and the normal group. A 80gm force rubber band was used as a orthodontic appliance between upper incisors and right upper 1st molar, and left side of experimental rats with no appliance was regarded as a control side. The samples of alveolar bones were obtained from pressure and tension sites in all three groups. respectively, and in control sides, too. The results were as follows. 1. The change in total collagen remains stable in both pressure and tension sites of all three groups, compared with control side by the time consuming. 2. The change in soluble collagen showed the most highest level in tension site, lowest level in pressure site of $PGE_2$ treated group in 5th. experimental day. 3. The change in chondroitin sulfate showed the most highest level in pressure site, lowest level in tension site of $PGE_2$ treated group in 5th. experimental day. 4. In indomethacin treated group, the change of soluble collagen and chondroitin sulfate showed small range of variance compared with $PGE_2$ treated and normal group.

Angle씨 제III급 부정교합의 두개 및 악안면 경조직에 관한 연구

박세진(Sei Jin Park),유영규(Young Kyu Ryu) 대한치과교정학회 1987 대한치과교정학회지 Vol.17 No.1

This is to investigate the difference between craniofacial correlation of Angle´s clsss III malocclusion and that of normal occlusion. For this investigation, 28 adult males and famales, who have class III malocclusion, and 35 adult males and 46 adult females, who have normal occlusion were selected to measure actual dimension of cranial base and to investigate ratio of various parts of maxillofacial skeleton against cranial base Class III malocclusion were, also, classified based on SNA and SNB angle In normal range. Results were as follows. 1. In class III malocclusion, actual dimension of cranial base were appeared to be less than normal occlusion in both sex. 2. In class III malocclusion, values were less than normal occlusion In BN/ptm-A in both sex, but had no significance between two. 3. In class III malocclusion, ramal inclination, mandible inclination, BN/Go-Pog, lower gonial angle were appeared to be greater Thus, characteristic mandibular protrusive appearance of class III malocclusion was due to relative ratio and morphologic characteristic of mandibular body dimension against cranial base. 4. In class III malocclusion, upper incisors were labially tilted and lower incisors were lingually tilted compared to normal occlusion. 5. In typing of class III malocclusion, the most common type was found to be one which maxillas were in normal range, while rnandibles were in protrusive tendency.

지렁이분립(糞粒) 추출물(抽出物)이 오이의 초기생장(初期生長)에 미치는 영향(影響)

朴洗震 ( Sei Jin Park ),李柱三 ( Ju Sam Lee ),金明苑 ( Myong Won Kim ) 한국유기농업학회 1994 韓國有機農業學會誌 Vol.3 No.1

Worm cast is one of the most effective and the least harmful organic fertilizer. The purpose of this work is to elucidate the physiological role of worm cast in the plant growth. Worm cast extract contains 17.83ppm of zinc, but either cadmium or lead were not detected in it. Cucumber (Cucumis sativus L. cv. H. N. Semiwhite) was germinated and incubated with percentage-varied extract. While 10% extract stimulated sprouting of seeds, 100% extract had no effect on it. 50% extract and 100% extract enhanced hypercotyl elongation and fresh weight most effectively. Dry matter and zinc concentration in hypercotyl were incresed as percentage of extract increased. Protein content was not affected by extract. 100% extract inhibits water uptake of seedling. Considering these, enhancement of seedling growth was mainly based on increment of water uptake.

자궁경부암에서 Sentinel Lymph node의 동정과 발견률에 영향을 미치는 요소에 대한 연구

박현 ( Hyun Park ),성석주 ( Seok Ju Seong ),박세진 ( Sei Jin Park ),강선영 ( Sun Young Kang ),이인호 ( In Ho Lee ),우혁준 ( Hyuk Jun Woo ),이제훈 ( Je Hoon Lee ),김주명 ( Joo Myung Kim ),김태진 ( Tae Jin Kim ),임경택 ( Kyung Taek 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.7

신증후 출혈열 예방 백신의 안정성에 미치는 Gelatin의 영향

김종호(Jong-Ho Kim),박세진(Sei-Jin Park),이인재(In-Jae Lee),심형섭(Hyung-Sup Shim),안창남(Chang-Nam An),신광순(Kwang-Soon Shin),이호왕(Ho-Wang Lee) 大韓微生物學會 1993 大韓微生物學會誌 Vol.28 No.1

난소의 악성 배세포 종양의 임상병리학적 고찰

이인호 ( In Ho Lee ),이기헌 ( Ki Heon Lee ),박세진 ( Sei Jin Park ),홍원기 ( Won Ki Hong ),김태진 ( Tae Jin Kim ),임경택 ( Kyung Taek Lim ),심재욱 ( Jae Uk Shim ),박현 ( Hyun Park ),성석주 ( Seok Ju Seong ),박종택 ( Chong Taik Pa 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.4

목적: 본 연구의 목적은 난소에 발생하는 악성 배세포 종양의 임상병리학적 특징을 알아보고자 하였다. 연구방법: 1995년 1월부터 2003년 12월까지 제일병원에서 난소의 악성 배세포 종양으로 진단받고 치료받은 35명의 환자를 대상으로 환자의 나이, 주증상, 조직학적 특징, 종양표지물질, FIGO 병기, 종양의 최대직경, 치료, 생존율, 향후 임신에 대한 결과를 의무기록을 토대로 후향적으로 분석하였다. 결과: 환자의 나이는 8세부터 34세까지 분포하였고 평균 23.4세였으며, 2명은 초경이전이었다. 추적관찰기간은 최소 16개월부터 최대 118개월로 평균 59.6개월이었다. 촉지되는 하복부 종괴와 통증이 가장 흔한 증상이었다. 수술전에 시행한 CA-125 검사는 32명에서 시행하였으며 이 중 23명에서 상승되었다. 종양의 최소직경은 7 cm, 최대직경은 27 cm이었으며 평균 16.5 cm이었고, 종양의 위치는 우측이 17명 (48.6%), 좌측이 15명 (42.9%), 양측이 3명 (8.6%)이었으며 양측성은 모두 미분화세포종이었다. 수술후 병기는 I기가 28명 (80.0%)으로 가장 많았으며, II기가 4명 (11.4%), III기가 3명 (8.6%)이었고 IV기는 없었다. 조직학적 분류는 미성숙 기형종이 14명 (40%)으로 가장 많았으며, 미분화세포종이 10명 (28%), 내배엽동 종양이 9명 (26%), 혼합 배세포종이 2명 (6%)이었다. 수술적 치료는 일측 부속기 절제술을 시행받은 환자가 9명, 종양절제술만 시행한 환자가 4명, 병기수술을 시행받은 환자가 22명이었으며, 이중 16명은 가임력을 보존하는 수술을 시행받았다. 수술후 항암화학요법은 30명에서 시행하였으며, TIP를 시행받은 1명을 제외하고는 모든 환자에서 BEP를 사용하였다. 내배엽동 종양환자 2명이 재발하였는데 1명은 병기 Ic였고, 1명은 IIIb였으며, 각각 첫 수술 후 59개월과 16개월 후에 각각 사망하였다. 추적관찰 기간 중 8명의 환자에서 임신이 되었으며, 그 결과는 만삭분만이 4명, 유산이 2명, 포상기태 1명, 그리고 현재 임신 20주인 산모가 1명이었다. 결론: 대부분의 악성 배세포 종양이 초기에 발견되며, 보존적 수술과 복합항암화학요법으로 상대적으로 높은 생존율을 보여준다. Objectives: The aim of this study was to evaluate the clinicopathologic characteristics of malignant germ cell tumors of ovary. Methods: Thirty five patients who were dignosed as malignant germ cell tumors of ovary and treated in Cheil General Hospital from January 1995 to December 2003, were retrospectively analyzed. The age, chief complaints, histologic type, tumor marker, FIGO stage, maximal tumor diameter, management, survival and future pregnancy outcome were reviewed. Results: The mean age was 23.4 years (8-34) and 2 patients were premenarche. The mean follow-up period was 59.6 months (16-118). Palpable lower abdominal mass and pain were the most frequent symptoms. Preoperative CA125 were checked in 32 patients and elevated in 23 patients. The tumors were ranging from 7cm to 27cm in diameter (mean : 16.6). The site of tumors was right-sided in 17(48.6%), left-sided in 15(42.9%), and bilateral in 3(8.6%) which were dysgerminomas only. Post-surgical FIGO stage was stage I in 28 cases (80.0%), stage II in 4 cases (11.4%), and stage III in 3 cases (8.6%). Histologically, immature teratomas were found most frequently (n=14, 40.0%), followed by dysgerminoma (n=10, 28.6%), endodermal sinus tumor (n=9, 25.7%), and mixed form (n=2, 5.7%). Unilateral salpingo-oophorectomy was performed in 9, cystectomy in 4, and staging operation in 22, which included 16 patients of fertility sparing operation. Postoperative chemotherapy was administered in 30 and most were BEP except one TIP. Two patients had recurred, who were stage Ic and IIIb EST at diagnosis and expired at 59 and 16 months after first operation. Recurrence rate was 5.7% and 5-year survival rate was 94.7%. During follow-up period, 8 patients were pregnant and the results were 4 normal deliveries at term, 1 missed abortion, 1 therapeutic abortion due to acne medication, 1 H-mole and 1 current pregnant state at 20 weeks without problem. Conclusion: These results shows that most malignant germ cell tumors of ovary is detected in early stage and have relatively excellent survival with conservative operation and combination chemotherapy.

자궁내막암 환자에서 림프-혈관 침윤의 임상적 고찰

유원식 ( Won Sick Yoo ),홍재식 ( Jae Shik Hong ),박세진 ( Sei Jin Park ),권용순 ( Yong Soon Kwon ),이인호 ( In Ho Lee ),김태진 ( Tae Jin Kim ),이기헌 ( Ki Heon Lee ),심재욱 ( Jae Uk Shim ),목정은 ( Jung Eun Mok ),임경택 ( Kyung Ta 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.3

Angle씨 제Ⅲ급 부정교합의 두개 및 악안면 경조직에 관한 연구

박세진,유영규 대한치과교정학회 1987 대한치과교정학회지 Vol.17 No.1

This is to investigate the difference between craniofacial correlation of Angle’s class III malocclusion and that of normal occlusion. For this investigation, 28 adult males and famales, who have class III malocclusion, and 35 adult males and 46 adult femals., who have normal occlusion were selected to measure actual dimension of cranial base and to investigate ratio of various parts of maxillofacial skeleton against cranial base. Class III malocclusion were, also, classified based on SNA and SNB angle in normal range. Results were as follows. 1. In class III malocclusion, actual dimension of cranial base were appeared to be less than normal occlusion in both sex. 2. In class III malocclusion, values were less than normal occlusion in BN/ptm-A in both sex, but had no significance between two. 3. In class III malocclusion, ramal inclination, mandible inclination, BN/Go-Pog, lower gonial angle were appeared to be greater. Thus, characteristic mandibular protrusive appearance of class III malocclusion was due to relative ratio and morphologic characteristic of mandibular body dimension against cranial base. 4. In class III malocclusion, upper incisors were labially tilted and lower in cisors were lingulally tilted compared to normal occlusion. 5. In typing of class III malocclusion, the most common type was found to be one which maxillas were in normal range, while mandibles were in protrusive tendency.

자가면역 간염 3증례: 진단 및 치료 반응

박세진, 채희복, 한정호, 윤순만, 박선미, 윤세진 충북대학교 의과대학 충북대학교 의학연구소 2012 忠北醫大學術誌 Vol.22 No.1

자가면역 간염의 정확한 진단을 위해서는 먼저 특징적인 자가면역 간염의 임상 양상과 검사 소견, 그리고 다른 원인에 의한 만성간염의 가능성을 배제할 수 있어야 한다. 본 연구는 2009년에서 2010 년의 자가면역 간염 증례 3례를 살펴 보았다. 아울러 진단 점수표를 이용하여 자가면역성 간염 진단의 객관성을 검토해 보고자 하였다. 본 증례보고는 2009년에서 2010년까지 본 병원에서 자가면역 간염 으로 진단되었던 세 증례에 관한 연구이며, 주로 진단과 치료에 대한 반응을 중심으로 기술하였다. 혈 액을 이용한 간기능 검사는 치료 전과 치료하는 기간 동안 내내 지속적으로 매 1주일마다 시행되었다. 3명의 환자들은 모두 여성으로 평균 나이는 53.7세(48~64)였다. 세 명의 환자 모두에서 표준 치료 요법에 좋은 반응을 나타내었다. 간조직 검사는 2명의 환자에서 시행되었으며 자가면역간염에 부합하 는 병리소견을 나타내었다. 환자들은 prednisolone 단독요법이나 prednisolone과 azathioprine 병 합요법 치료를 받았다. 치료시작 시점으로부터 치료 종료에까지 걸린 시간은 한 달에서 두 달 사이에 분포하였다. 재발은 한 명의 환자에서 치료 종결 후 5개월 째 관찰되었다. 결론적으로 자가면역 간염 환자 세 명은 모두 전형적인 임상양상과 간기능 검사 소견을 나타내었다. 면역 억제 치료제를 투여하였 을 때의 치료반응은 매우 효과적이었으며, 대체로 한 달에서 두 달 사이에 신속하게 나타났다. 재발은 한 명의 환자에서만 관찰되었다.

Prostaglandin E₂와 Indomethacin이 백서 치조골 내 Collagen과 Chondroitin Sulfate의 정량 변화에 미치는 영향

박세진,손병화 대한치과교정학회 1990 대한치과교정학회지 Vol.20 No.2

The alveolar bone remodeling is essential in tooth movement by orthodontic forces. The collagen and chondroitin sulfate are acting as an important roles in bone remodeling. This study was performed to measure out the quantity of the collagen and chondroitin sulfate in the alveolar bone of rats applied by experimental orthodontic forces. The 150 Sprague-Dawley male rats were divided into the PGE₂treated group, indomethacin treated group and the normal group. A 80gm force rubber band was used as a orthodontic appliance between upper incisors and right upper 1st molar, and left side of experimental rats with no appliance was regarded as a control side. The samples of alveolar bones were obtained from pressure and tension sites in all three groups respectively, and in control sides, too. The results were as follows. 1. The change in total collagen remains stable in both pressure and tension sites of all three groups, compared with control side by the time consuming. 2. The change in soluble collagen showed the most highest level in tension site, lowest level in pressure site of PGE₂treated group in 5th. experimental day. 3. The change in chondroitin sulfate showed the most highest level in pressure site, lowest level in tension site of PGE₂treated group in 5th. experimental day. 4. In indomethacin treated group, the change of soluble collagen and chondroitin sulfate showed small range of variance compared with PGE₂treated and normal group.