http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
요추간반 탈출증에 있어 MED(Microendoscopic Discectomy) System을 이용한 수술의 효율성과 수기
홍현종,오성훈,백광흠,김재민,김충현,김영수,고용,오석전,김광명,이상구,김남규,Hong, Hyun Jong,Oh, Seong Hoon,Bak, Kwang Hum,Kim, Jae Min,Kim, Choong Hyun,Kim, Young Soo,Ko, Yong,Oh, Suck Jun,Kim, Kwang Myung,Lee, Sang Gu,Kim, Nam Kyu 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.1
Objective : Percutaneous lumbar approaches such as arthroscopic discectomy, laser discectomy, and nucleotome remain controversial and have technical limitations to free fragment disc, bony pathology and access to L5-S1, The purpose of this study was to determine efficacy of this new endoscopic system and to report techniques and tactics. Methods : From July 1997 to May 1998, we treated 40 consecutive patients(43 levels) with the MED system. Mean age was 32 years(range ; 18 to 62). There were 30 males and 10 females. All patients had sciatica with SLRT limitation. There were 23 patients with disc herniation at L4-5 and 14 patients at L5-S1. Three patients had 2 level disc herniations. There was one far lateral disc herniation at L4-5. Results : Using modified MacNab criteria, there were 37 excellent results and 3 good result. Most patients were discharged within 3-4 days except 2 patients with dural tearing. There were no other complications. Mean operation time was 1.5 hours(range : 40 minutes to 2.5 hours). Conclusion : The MED system is a reliable approach to lumbar disc herniations. This system combines the advantages of conventional open surgery and a minimally invasive technique. As tactics for the doctors who wish to attempt, "palpate" the lamina by first dilator, identification of interlaminar space by removal of overlying soft tissue and confirmation of the shoulder portion of nerve root before discectomy are important to this procedure. We conclude that lumbar disc herniations can be successfully treated with MED approach.
두통을 주소로 내원한 베체트병 환자에서 상악동 내 발생한 림프종
홍현종 ( Hyun Jong Hong ),이상엽 ( Sang Yeob Lee ),김혜인 ( Hye In Kim ),황진연 ( Jin Yeon Hwang ),조용민 ( Yong Min Jo ),류환철 ( Hwan Cheol Ryu ),이성원 ( Sung Won Lee ),정원태 ( Won Tae Chung ),김대철 ( Dae Cheol Kim ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.1
Behcet`s disease is chronic and systemic inflammatory vasculitis, characterized by immunologically involving in variable size of arteries and veins. Clinically, principal manifestations are recurrent oral ulcer, genital ulcer, skin and eye lesions. Compared to other connective tissue disease, cancer is not accompanied commonly in Behcet`s disease. But, immunological confusion such as T cell depletion or B cell hyperplasia, or long-term of immunosuppressive treatment lead to occurrence of malignancy. Recently, we experienced a case of maxillary mass, induced to abrupt headache in Behcet`s disease, confirmed diffuse large B cell lymphoma by biopsy, and treated by rituximab-CHOP chemotherapy. Thus we report these with literature review.
이정훈 ( Jung Hoon Lee ),홍현종 ( Hyun Jong Hong ),권정택 ( Jeong Taik Kwon ),김영백 ( Young Baeg Kim ),석종식 ( Jong Sik Suk ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2007 대한뇌종양학회지 Vol.6 No.1
Meningiomas constitute about 15 to 18% of all intracranial tumors and are usally located in the subdural compartment. Intradural meningiomas may secondarily involve the overlying calvarial bone and provoke osteoblastic or, less commonly, an osteolytic reaction. Meningiomas developing outside the dura mater, without an intradural counterpart, are rare and have been reported in only 1 to 2% of all intracranial meningiomas. We present a rare case of coexisted subdural and extradural meningioma.
좌측 실비우스 종양 수술 후 생긴 양측성 소뇌출혈 -증례보고-
석주완 ( Ju Wan Seok ),김충현 ( Choong Hyun Kim ),홍현종 ( Hyun Jong Hong ),정진환 ( Jin Hwan Cheong ),김재민 ( Jae Min Kim ),오영하 ( Young Ha Oh ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2009 대한뇌종양학회지 Vol.8 No.2
Hemorrhagic complications may be occasionally developed after intracranial surgery. However, remote cerebellar hemorrhage( RCH) following supratentorial surgery is uncommonly reported. A 49-year-old male presented with seizure, which was characterized by a generalized tonic-clonic type for 3 times. There was a well-enhanced round mass in the preoperative brain magnetic resonance(MR) image. We performed tumor resection with left frontotemporal craniotomy. Pathological examination of tumor specimen was confirmed as a malignant meningioma. There was no hypertensive event or coagulopathy in the perioperative period. On the follow-up brain computed tomography(CT) scans taken at 48 hours after surgery, it revealed bilateral streaky intracerebellar hemorrhage. The patient was recovered by the conservative treatment without any neurological deficits. This case report emphasizes an importance of close monitoring of patients to detect rarely occurring complications like RCH. The authors also review pertinent literatures and discuss a pathogenesis of RCH.
골관절염 환자의 연골조직에서 TRAIL과 그 수용체 발현에 관한 연구
이상엽 ( Sang Yeob Lee ),구정모 ( Jeong Mo Koo ),유현승 ( Hyun Seung Yoo ),김영훈 ( Young Hoon Kim ),김자원 ( Ja Won Kim ),이재훈 ( Jae Hoon Lee ),홍현종 ( Hyun Jong Hong ),김혜인 ( Hye In Kim ),박수경 ( Su Kyung Park ),이성원 ( S 대한내과학회 2008 대한내과학회지 Vol.74 No.3
목적: 연골세포의 자멸은 골관절염의 병인에 중요한 역할을 하고 있으며 자멸을 유도하는 다양한 인자들이 알려져 있다. 이들 중 TRAIL은 연골세포의 자멸을 유도하여 골관절염의 병인에 기여한다고 알려져 있다. 이에 본 연구는 골관절염 환자의 연골조직에서 TRAIL 발현 여부를 관찰하고 골관절염의 병인으로서 TRAIL의 역할을 알아보고자 하였다. 방법: 2005년 2월부터 2006년 2월까지 본원을 방문하여 무릎 관절 인공관절치환술을 받은 골관절염 환자 25명을 대상으로 인공관절치환술 후 제거되는 환자의 무릎 관절 부분을 수합하여 4% PFA에 24시간 처리하여 고정한 후 실험을 수행하였다. 또한 수술 받은 환자 25명 중 20명에게서 수술직전, 관절액을 미리 채취한 뒤 변성을 막기 위하여 즉시 -70℃에 보관한 후 실험에 사용하였다. 또한 골관절염의 병력이 없었던 7명의 부검 예에서 관절액을 채취하여 실험의 대조군으로 사용하였고, 추출된 표본은 면역조직화학 검사와 면역형광 염색, 그리고 ELISA 법을 이용하여 TRAIL의 발현 정도와 활성도를 관찰하였다. 결과: 골관절염 환자 25명 전원의 관절연골에서 TRAIL과 그 사멸 수용체가 발현되었다. 사멸 수용체 중 DR4와 DR5가 발현되는 위치가 모두 TRAIL이 발현되는 위치와 동일하여 이들 사멸 수용체의 발현과 TRAIL의 발현이 연골세포의 자멸에 관여한다는 것을 알 수 있었다. 골관절염 환자 20명 중 4명의 관절액에서 TRAIL의 발현이 확인되었으며 환자군에서 발현양은 약 80~120 ㎍/ppm 사이였고, 대조군에서는 TRAIL 발현이 0~2 ㎍/ppm으로 골관절염 환자의 관절액에서 TRAIL 발현양이 높았다. 결론: 골관절염 환자의 연골조직에서 TRAIL과 TRAIL 수용체가 발현되며 이는 최근 골관절염의 주된 병인으로 생각되고 있는 연골세포의 자멸을 유도하는 중요한 인자로서 생각된다. 향후 골관절염 환자에서 TRAIL 발현에 대한 추가적인 연구와 TRAIL을 선택적으로 억제할 수 있는 방법의 개발에 대한 연구가 필요할 것으로 생각된다. Background/Aims: The apoptosis of chondrocytes is assumed to be involved in the pathogenesis of osteoarthritis (OA), and the TNF related apoptosis inducing ligand (TRAIL) is thought to have a pivotal role in the apoptosis of chondrocytes. We investigated the expression of TRAIL and its receptors in human osteoarthritic cartilages. Methods: Human OA cartilage tissues were obtained from the medial side of the cartilage in the knee joints of 25 patients who underwent total knee replacement surgery, and the normal human cartilages of the knee joint were obtained at autopsy from seven young adults who had no history of joint diseases. The expressions of TRAIL and the death receptor were analyzed by immunohistochemistry or immunofluorscent staining. The concentration of TRAIL in the synovial fluid was measured by enzyme-linked immunosorbent assay. Results: TRAIL and its receptors were expressed in the OA cartilage, but not in the normal cartilage. TUNEL staining and immunohistochemistry for TRAIL on the serial sections showed that most TRAIL positive cells were TUNEL positive. The OA joint fluid contained concentrations of TRAIL that were readily detectable (80 and 120 ㎍/ppm in the synovial fluid of each, respectively). However, the synovial fluid of the knee joint obtained at autopsy from the seven young adults contained low concentrations of detectable TRAIL (0~2 ㎍/ppm). Conclusions: These results support the notion that TRAIL and its receptors are involved in the pathogenesis of human OA. A better understanding of TRAIL-induced apoptosis in chondrocytes might lead to the development of a new therapeutic strategy for OA.
김경태 ( Kyoung Tae Kim ),권정택 ( Jeong Taik Kwon ),홍현종 ( Hyun Jong Hong ),이용철 ( Yong Chul Lee ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2005 대한뇌종양학회지 Vol.4 No.1
Intracranial epidermoid tumors usually show homogeneous hypodensity on CT scans and hypointensity on T1-weighted and hyperintensity on T2-weighted MR images. Epidermoid tumors are most often located in the cerebellopontine angle and in the parasellar region. We report an unusual case of middle cranial fossa epidermoid tumor. The tumor showed inhomogeneous low density on CT scan and heterogeneous signal intensity on both T1- and T2-weighted MR images. Epidermoid tumors are usually slow growing tumor and are located in adjacent region of cranial nerve, so we must consider age and postoperative neurological defici of patient before operation.
구정모 ( Jeong Mo Koo ),김영훈 ( Young Hoon Kim ),홍현종 ( Hyun Jong Hong ),김혜인 ( Hye In Kim ),윤성국 ( Seong Kuk Yoon ),안원석 ( Won Suk An ),이성원 ( Sung Won Lee ),정원태 ( Won Tae Chung ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.2
Idiopathic retroperitoneal fibrosis (IRF) is a rare disease characterized by inflammatory and fibrous tissue proliferation in the retroperitoneum, which often surrounds the adjacent retroperitoneal structure to cause compressive complications such as hydronephrosis. Its pathogenesis is still unknown, but recently the association with autoimmune disease is being suggested. Although the prognosis is generally good, if diagnosis or treatment is delayed, the disease can progress to acute or chronic renal failure. In the past, surgical procedures such as ureterolysis or transpositioning of the involved ureter were the mainstay of the treatment. But recent studies using steroids, immunosuppressants and tamoxifen have reported generally good results. However, the adequate dose or duration of medical treatment and the treatment for recurred disease have not been established yet. We report a case of that retroperitoneal fibrosis recurred 1 year after 2-weeks steroids therapy. It was successfully treated with combination therapy of steroids and tamoxifen.
드문 혈관 압박에 의한 삼차신경통과 Tic Convulsif
홍현종,김한식,권정택,박관,민병국,석종식 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.5
Trigeminal neuralgia is a cranial rhizopathy characterized by paroxysms of hyperactivity strictly limited to the anatomical distributions of the fifth cranial nerve. One of a documented cause is vascular cross-compression at the root entry zone of the fifth cranial nerve near the brain stem. The offending vessels are the superior core-bellar artery. anterior inferior cerebellar artery small arteriole. vein only. and vertebrobasilar artery in order of frequency. When trigeminal neuralgia and hemifacial spasm occur together in the same patient in rats occasions. they are termed "tic convulsif" We have recently experienced three cases of trigeminal neuralgia caused by unusual offending vessels and one case of tic convulsif. They were treated by microvascular decompression using Teflon felt. Post-operative courses were uneventful and marked symptomatic improvement had beef achieved.