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      • 위, 십이지장 질환에서 검사방법에 따른 Helicobacter Pylori 양성율의 비교연구

        류홍옥,설상영,오상훈 인제대학교 1995 仁濟醫學 Vol.16 No.2

        H. pylori가 위,십이지장질환 특히 만성 활동성 위염 및 소화성 궤양의 병인이 된다는 것이 밝혀졌고, 최근에는 위궤양과 위암에서의 병인론적 역할에 대한 많은 연구가 이루어지고 있다. 위,십이지장 질환들에서 H. pylori의 감염율에 대한 보고들을 보면 보고자마다 차이가 있는데, 이는 H. pylori 감염 진단법의 민감도 차이로 설명할 수 있겠다. 이에 저자들은 H. pylori의 진단검사 즉, 조직 urease 검사(CLO 검사), Touch print 후의 Gram 염색검사, 배양검사 그리고 H & E 및 Giemsa 염색검사를 시행하여 각 위,십이지장 질환에서의 H. pylori의 감염율 및 각 검사의 민감도를 알아 보고 어떤 검사법이 임상적으로 민감도와 특이도가 높으면서 쉽게 할 수 있는 검사법인지 알아보고자 한다. Numerous studies about the pathogenic role of Helicobacter pylori(H. pylori) in gastroduodenal disease haute been carried out actively and H.pylori has been strongly implicated as a cause of chronic active gastritis and duodenal ulcer. Many detective methods of H. pylori have been developed, but few studies have been reported about the sensitivity or applicability of these detective methods. Therefore, we evaluate the sensitivity of detection methods for H. pylori Infection in gastroduodenal disease. CLO test, Gram stain of touch print, culture, and Giemsa stain were used for the detection of H. pylori in specimens obtained by endoscopic biopsy of the gastric antrum from 98 patients with gastroduodenal diseases including erosive gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, and gastric cancer. In conclusion, the most sensitive method was Giemsa stain and the next was CLO test. These two methods were effective in diagnosis of H. pylori infection. CLO test was considered to be a relatively speedy and simple detective method.

      • 경남해안지역에서 발생하여 본원에 입원한 Vibrio vulnificus 패혈증의 역학 및 임상상 : Twenty Four Cases Confirmed by Culture Between 1984 and 1991 1984년에서 1991년 사이에 균배양검사로 확인된 24예

        류홍옥,전종휘 대한감염학회 1992 감염 Vol.24 No.3

        We studied the epidemiology and clinical characteristics of Vibrio vulnificus septicemia in 24 patients from whom the organism has been isolated. 1) All patients came from the coastal or near-coastal area of Pusan and Kyungnam province. 2) Most cases (87%) occurred during the summer months (July, August, September) in men (92%), and in persons 40 or more years of age (88%). 3) The illness began with septicemia, often within 3 days of the consumption of raw seafood (54%) although additional 2 cases had history of consumption of seafood cooked. 4) Twelve patients (55%) had preexisting chronic hepatic diseases, and 16 (73%) had a history of heavy alcoholism. 5) The skin lesions that were present on admission in 21 cases (88%) appeared on the legs in 17 (81%) of the cases. 6) V.vulnificus was isolated from the blood (83%) and from the skin lesion (69%). 7) Nineteen of 24 patients (79%) died, of whom mean interval between the onset of illness and death was 4 days. Leukopenia seemed to be bad prognostic factor (p<0.05). Because V.vulnificus septicemia is a highly fatal disease, persons with chronic liver disease or alcholism should avoid eating or handling raw seafood.

      • 급성 심근경색 후의 좌심실류를 동반한 심실중격결손증 2례

        김기환,류홍옥,문영수,고원섭,이광재,이건주,최석구,유원상 인제대학교 1989 仁濟醫學 Vol.10 No.1

        Rupture of the interventicular septum, one of the must serious complication of acute myocardial infarction, requires prompt diagnosis and evaluation for surgical intervention. In two cases, we performed right heart catheterization, and two dimensional and Doppler echocadiogram for diagnosis.

      • Infection-Associated Hemophagocytic Syndrome 1예

        구대식,류홍옥,김규환,전종휘 대한감염학회 1993 감염 Vol.25 No.1

        IAHS is a rare clinicopathologic entity characterized by fever, pancytopenia, liver dysfunction and the reactive proliferation of histiocytes actively phagocytosing hemopoietic cells, simulating the malignant histiocytosis, but distinct in that the phagocytosing histiocytes are morphologically mature and benign. This syndrome occurs in patients who develop infections in the setting of preexisting immunological abnormalities or neoplasm, and usually runs a self-limited course, although in a minority of cases fatal outcomes ensue. Recently, the author experienced a case of IAHS developed during immunosuppressive therapy in uveitis patient. So we report this case with brief review of literatures.

      • 동맥관개존증에 병발된 심내막염 1례

        김환태,구대식,류홍옥,김동수,이경순 인제대학교 1992 仁濟醫學 Vol.13 No.4

        선천성 심장병인 동맥관개존증에 병발된 감염성 심내막염으로 인해 승모판과 주폐동맥에 발생한 증식성 병변을 항생제와 고식적 치료에 의해 증식성 병변은 소실되고 동맥관개존증은 ligation에 의해 호전된 1례를 경험하였기에 보고하는 바이다. Infective endocarditis is an infection which produces vegetations on the endocardium. A heart valve is usually involved, but infection may be on a septal defect or mural endocardium. Infection of arteriovenous shunt or coarctation of the aorta is more properly called endarteritis. The association between congenital heart disease(CHD) and endocarditis was firmly established. Ventricular septal defect, patent ductus arteriosus(PDA), and tetralogy of Fallot have been the most common underlying lesions. We experienced a case of infective endocarditis on PDA with multiple vegetations of mitral valve and mall pulmonary antery. The vegetations were detected by echocardiography and gradually reduced in size after antibiotics were given. PDA was corrected by surgical ligation after medical treatment.

      • 쯔쯔가무시병 59례의 임상적 고찰(1986∼1993)

        조현대,김주인,류홍옥,강창일,전종휘 인제대학교 1995 仁濟醫學 Vol.16 No.1

        쯔쯔가무시병은 늦가을철에 전국적인 규모로 발생하는 급성 열성질환의 하나로 늦가을철 급성 열성 질환 환자에서 반드시 감별진단에 생각해야 할 질환이다. 이에 저자들은 1986년부터 1993년까지 인제대학교 의과대학 부산백병원에 입원하여 임상양상 및 간접면역형광항체법으로 쯔쯔가무시병으로 확진된 59례에 대한 역학 및 임상적 특징을 알아 보고, 문헌 고찰과 함께 보고하는 바이다. Tsutsugamushi disease is one of the important acute febrile illnesses with the high incidence during the late fall throughtout Korea, especially in rural areas. So, to define the clinical and epidemiological characteristics of Tsutsugamushi diseases we analized 59 cases of Tsutsugamushi diseases admitted to Inje University, Pusan Paik Hospital between 1986 and 1993 The results were as follows ; 1) The ratio of male and female was 1:1.4 (24 cases : 35 cases), indicating that incidence was prominantly high in female and large proportion of the patients were over 40 years old (44 cases, 75%) 2) The number of annual incidence from 1986 to 1993 were 1, 6, 8, 9, 11, 10, 9, 5, respectively and there was peak occurrence between October (25 cases, 42%) and November (30 cases, 51%), 3) The majority of patients resided in rural area (22 cases, 37%), or had prevalence area exposure (25 cases, 42%). The patients were distributed throughout the whole area of Pusan and Kyungnam province. 4) The most frequent symptoms were fever (59 cases, 100%) and chills (49 cases, 83%). 5) Rash and eschar were observed in 80%(51 of 59) and 70%(41 of 59), respectively. Lymphadenopathy and hepatosplenomegaly were also observed in 20%(12 of 59) and 12%(7 of 59), respectively. 6) The laboratory findings showed the elevation of AST in 75%(44 of 59), ALT in 70% (41 of 59), ESR in 56% (33 of 59), and leukocytosis in 32% (19 of 59). Hypoalbuminemia and proteinuria were also observed in 62%(36 of 59) and 32%(19 of 59), respectively. 7) Treatment was effectively carried out by Tetracycline or Doxycycline and the mean duration of fever following treatment was 3.5 days/ Tsutsugamushi disease is one of the important acute febrile illnesses with the high incidence between October and November in whose area of Pusan and Kyungnam province.

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