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Metabolic loading of guanosine induces chondrocyte apoptosis via the Fas pathway
김동조,정준호,류은경,임정효,류윤식,박소현,김경태,강흔수,정홍근,박상철 생화학분자생물학회 2006 Experimental and molecular medicine Vol.38 No.4
Although the apoptosis of chondrocytes plays an important role in endochondral ossification, its mechanism has not been elucidated. In this study, we show that guanosine induces chondrocyte apop - tosis based on the results of acridine orange/ ethidium bromide staining, caspase-3 activation, and sub-G1 fraction analysis. The potent inhibitory effect of dipyridamole, a nucleoside transporter blocker, indicates that extracellular guanosine must enter the chondrocytes to induce apoptosis. We found that guanosine promotes Fas-Fas ligand interaction which, in turn, leads to chondrocyte apoptosis. These findings indicate a novel mechanism for endochondral ossification via metabolic regulation.