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- 저자 : 노재윤(JY Ro) (검색결과 5 건)
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권태정(TJ Kown),노재윤(JY Ro),김대현(TH Kim),이국(K Lee) 대한산부인과학회 1979 Obstetrics & Gynecology Science Vol.22 No.3
18세 여자환자의 양측 난소에서 Burkitt씨 임파종 1예를 경험하여 그 임상적, 병리조직학적, 조직화학적 및 전자현미경적 검사를 실시하여 보고하고 아울러 문헌고찰을 시행하였다. 그 결과 우리나라에서도 Burkitt씨 임파종이 발생될 수 있을 것으로 생각되었으며 임상학적으로나 조직학적으로 전형적인 경우 과감하게 Burkitt씨 임파종이라고 진단해도 좋을 것으로 사료되었다. Burkitts lymphoma which shows widespread multi-organ involvement with relative sparing of peripheral lymph nodes and spleen is a highly malignant neoplasm of lymphoreticular system. Ever since the tumor was first recognized as jaw sarcoma among East African childrens(Burkitt; 1958), it has continued to be the subject of intensive epidemiologic, immunologic, etiologic, histochemical and ultrastructural studies. The classic light microscopic criteria of the Burkitts lymphome are; 1. the starry-sky appearance produced by the presence of non-neoplastic phagocytic histiocytes in a field of monomorphic undifferentiated lymphoreticular cells, 2. the histochemical triad of pyroninophilia, osmiophilia and PAS negativity in tumor cells. Electron microscopy not only reveals the characteristic nuclear and nucleolar features of the primitive lymphoreticular cells but also documents the presence in the cytoplasm of abundant ribosomes, frequent lipid inclusions, and absence of glycogen particles. I case of Burkitt`s lymphoma in the both ovaries which seemed to be one of the favorite sites of tumor was reported here. The patient was 18-year-old female and complained of lower abdominal palpable mass. A brief review of the literatures was also made.
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박종택(JT Park),노재윤(JY Ro),노경병(KB No),이유복(YB Lee),김동식(DS Kim) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.7
1971년 1월부터 1975년 12월말까지 만 5년간 연세대학교 의과대학 병리학교실에서 검색한 자궁경부 악성종양 총 1,243예에 대하여 임상 및 병리조직학 검사를 하여 다음과 같은 결론을 얻었다. 1) 자궁경부암은 같은 기간동안 발생된 전 여성 악성종양의 42.8%를 점하였다. 2) 검색한 총 1,243예의 자궁경부 악성종양중 편평상피암이 1,187예인 95.5%를 차지하였다. 3) 편평상피암중 상피내암, 침윤이 의심되던가 혹은 현미경적 침윤암 및 침윤암의 평균연령은 각각 42.9세, 45.0세 및 47.9세였으며 선암의 평균연령은 49.2세였다. 4) 편평상피암의 임상증상으로는 부정 성기출혈(56.5%), 악취대하(35.1%), 접촉성출혈(24.8%)등이었고 병력기간은 6개월이내가 66.1%였으며 평균 병력기간은 5.8개월이었다. 5) 초경이 16세에 있었던 환자가 73예로 가장 많았고 초혼연령은 16~21세 사이가 가장 많았으며 환자의 반수 이상인 53.3%에서는 폐경기 이후였다. 임신 및 분만횟수는 5~8회가 45.0% 및 47.0%로 가장 많았다. 6) 임상 각 기별 분포는 침윤암 350예중 48.6%가 제 2기였고 다음이 제 3기, 1기, 4기의 순위였다. 7) 상피내암과 침윤이 의심되던가 혹은 현미경적 침윤암의 상피내암의 핵유형으로는 small rounded type이 43.7%로 가장 많았다. 8) 침윤암의 분화 및 조직학적 세포유형에 따른 분류로는 Modified Broders Grade Ⅰ, Ⅱ, Ⅲ가 각각 2.5, 37.4 및 59.1%였고 large cell non-keratinizing, keratinizing, small cell형이 각각 83.3, 11.6 및 4.1%였다. 9) 분화정도에 따른 Brodersgrade와 조직학적 세포유형에 따른 분류가 각 기별 분포에 미치는 영향을 보면 분화정도와 각 기별 분포사이에는 별 연관이 없었으나 세포유형에 따른 분류와는 의의있는 관련이 있었다. 이상의 결론을 종합하여 보면 한국인에서 자궁경부암의 발생빈도는 상당히 높았고, 서구에 비하여 다소 젊은층에 호발되었으며 침윤암의 경우 조직학적 세포유형에 따른 분류가 예후와 연관이 많을 것으로 사료되었다. Clinical and histopathological studies were made on 1243 cases of malignancies of uterine cervix, that were submitted to the Department of Pathology, Yonsei University College of Medicine, during the period of 5 years from 1971 to 1975. The results were asummarized as follows; 1. Malignancies of the uterine cervix were 26.3% of total cancer of both sexes, and 42.8% of total female malignancies. 2. Among 1243 cases, 1187 cases(95.5%) were squamous cell carcinoma, in which 194 cases (15.6%) of in situ carcinoma, 72 cases(5.8%) of suspected or microinvasive carcinoma and 921 cases(74.1%) of invasive carcinoma were included. The adenocarcinoma was found in 48 cases(3.9%). 3. The average age of the patients with squamous cell carcinoma was 46.9 year-old; in cases of in situ carcinoma, it was 42.9, suspected or microinvasive, 45.0 and invasive, 47.9 year-old. The mean age of patients with adenocarcinoma was 49.2 year-old. 4. Clinical symptoms of the patients with squamous cell carcinoma in order of frequency were as follows; irregular vaginal bleeding(56.5%), vaginal discharge(31.1%) and postcoital bleeding(24.8%). Duration of the chief complaints was most commonly less than 6 months(66.1%) and the average duration was 5.8 months. 5. Among 260 patients with squamous cell carcinoma in which the age of the patients were noticed, menarche was most commonly 16 year-old(28.1%), and among 132 patients in which clinical histories were available, the most common age of marriage was between 19 to 21 year-old(37.9%). More than half of the patients(53.3%) were in post-menopausal period. Gravidity and parity 5-8 times in 45.0% and 47.0% with the average number of 6.7 and 4.8 times, respectively. 6. Subdivision of 350 cases of invasive carcinoma was made according to the clinical stage; stage Ⅰ, 170 cases(48.6%), stage Ⅱ, 108 cases(30.8%) and stage Ⅳ, 29 cases(8.3%). 7. The predominant nuclear configurations of the carcinoma in situ and suspected or microinvasive carcinoma were small rounded in 119 cases(43.7%), small elongate
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이국(K Lee),이윤호(YH Lee),김대현(TH Kim),박찬일(CI Park),이광길(KK Lee),노재윤(JY Ro) 대한산부인과학회 1980 Obstetrics & Gynecology Science Vol.23 No.1
결론 1. 자궁경관에 발생한 이소성 혼합육종의 1예를 보고하였다. 2. 근치자궁적출술 및 양축 골반 임파선적출술, 방사선치료, 불완전하나마 혼합약물요법같은 병합요법으로 치료한 예에서 1년간 재발없이 생존하였다. Mixed heterologous sarcoma of the uterine cervix is a rare and highly malignant tumor. A case of this type was recently experienced in a 20-year0old unmarried woman and served as the vasis of this report. The patient has been bollowed for 1 year without evidence of recurrence. Such tumors develop from the mesodermal tissue associated with mullerian duct and consist of heterologous and gifhly malignant tissues. A brief rebiew of literature is presented, especially concerning the current tend- ency of treatment : combined modality with surgery, radiotherapy and combinatation chemotherapy.
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