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      • KCI등재후보

        Enalapril 에 의한 기침 발생율

        노승익(Seung Ik Roh),김명선(Myeong Seon Kim),김은실(Eun Sil Kim),서두선(Du Seon Seo),정내인(Nae In Jeong),이명숙(Myeong Suk Lee),한승수(Seung Soo Han),김광희(Kwang Hoi Kim),김윤권(Yoon Kweon Kim) 대한내과학회 1994 대한내과학회지 Vol.47 No.1

        N/A Background: Enalapril is an angiotensin-converting enzyme inhibitor that has been widely used in treating hypertension, congestive heart failure, DM and various renal diseases. Cough has been recognized as a side effect of angiotensin-converting enzyme inhibitors. Therefore we studied the incidence and the chracteritics of Enalapril induced cough in Korea. Method: The sixty eight patients with Enalapril who visited out-patients department of internal medicine, Han-Il General Hospital during the period from april 1992 to october 1992 were included in this study. In all patients careful history taking and review of chart was done. Patients with respiratory disease were excluded. The criteria of angiotensin converting enzyme inhibitor induced cough was that cough developed after administration of Enalapril and improved after discontinuing drug and readministration of drug induce resume of symptom. Resnlts: Subjects include 34 males, 34 females and their average age was 53.3 years, Diseases of theirs were hypertension (57 cases}, congestive heart failure (5 eases), various renal disease (28 cases) and 9 patients of them were smokers. Average drug dosage was 11.7 mg a day and average administration duration was 182 days. Of the 68 patients, 23 patients (33.8%) had chronic cough due to enalapril, which had 12 male and 11 female patients. The cough disappearing time after withdrawal of the angiotensin-converting enzyme inhibitors was average 7.8 days. In 16 patients (two thirds of them), cough disappeared within 4 days after drug withdrawal. 9 patients had to stop taking drug because of severe cough. Generally the characters of cough induced by angiotensin-converting enzyme inhibitors were dry, persistent, tickling and tended to develope especially at night, Conclusion: Cough is not uncommon side effect in angiotensin-converting enzyme inhibitor users. There fore clinician should consider angiotensin-converting enzyme inhibitor induced cough initially when cough developed after angiotensin-converting enzyme inhibitor administration.

      • SCOPUSKCI등재

        131I 의 체외 방사선조사에 의한 염색체이상

        김종순(Chong Soon Kim),김은실(Eun Sil Kim),한승수(Seung Soo Han),김희근(Hee Geun Kim),강덕원(Duck Won Kang),송명재(Myung Jae Song),이재용(Jae Yong Lee),정내인(Nae In Jeong),이명선(Myung Soon Kim),서두선(Doo Seon Seo),노승익(Seung Ik 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1

        N/A Recently, there are many considerations and studies on biological effects of radiations in radiation workera, as well as in accidentally or therapeutically irradiated persons. The most practical and reliable method of dosimetry for radiation accidents is the scoring of gross chromosomal aberrations in human lymphocytes (Ydr) as a biological dosimetry. By the way, although usual doses of 131I administered therapeutically for thyroid cancer are ranging from 100 mCi to 200mCi, there are differences of absarbed doses and Ydr, ranging from 0.004 to 0.04, on equally administered 131I due to variations in metabolic characteristics, stage of tumors and physical status of subjects. In this study, We exert to obtain the dose-response relationships of 131I, as a good guide to evaluating acute effects of accidental irradiations and radiation induced leukemia or solid tumor, by in vitro induction of chromosomal aberrations. we studied the relationship between radiation dose <D) and the frequency of chromosomal aberrations (Ydr) obserbed in peripheral lymphocytes that were irradiated in vitro with 'I at doses ranging from 0.05 to 6.00 Gy. By scoring cells with unstable chromosomal aberrations (dicentric chromosomes and ring chromosomes) we obtained this linearquadratic dose response equation Ydr=0.064351 D 0.13143 D+0.045684 This dose-response relationship may be useful for evaluating acute and chronic I induced biological effects.

      • KCI등재후보

        세포의 체액이 증가된 환자에서의 99mTc-DTPA 를 이용한 사구체 여과율 측정의 유용성

        김정은,김종순,정창호,한승수,노승익,류영준,서두선,김윤권 대한내과학회 1993 대한내과학회지 Vol.45 No.6

        Obsectives: Of the several recent popular methods for measuring GFR using 99mTc-DTPA, it was reported that the Jackson urinary and russell two sample plasma methods are more accurate tests. But both tests have never been applied to patints with edema or ascites. In clinical practice, it is important to generate an accurate reproducible GFR in patients with changing renal function. Thus, we compared both tests with standard ioth-alamate clearance and evaluate the utility of both tests in patients with increased ECF volume. Methods: We measured Sigman's iothalamate clearance as a standard method and simultaneously measured 99mTc-DTPA clearance with Jackson urinary and Russell plasma methods in 20 patients with edema or ascites. In all patints, 24 hour creatinine clearance was mesured simultaneously, Results: 1) the range of GFR by iothalamate clerance (IC) was from 11.5 ml/min to 148 ml/min. 2) The correlation between IC and creainine clearance was described by Y=0.88X + S.30, r=0.952(p$lt;0. 01). 3) The correlatin between IC and Jackson urinary method was described by Y =0.88X + 8,30, r=0.972 (p$lt; 0.01), 4) The correlation between IC and Russell plasma method was described by Y=0.72X + 28,07, r=0.904 (p$lt;0.095, 30', 180') and by Y=0.76X + 26.70, r=0.914 (p$lt;0.05, 60', 180'). Conclusion: Jackson urinary method appears to be most reliable and precise measures of GFR in patients with increased ECF volume.

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