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Bong-Han Corpuscles as Possible Stem Cell Niches on the Organ-Surfaces
김민수,홍주영,홍수,이병천,남창훈,우희종,강대인,소광섭,Kim, Min-Su,Hong, Ju-Young,Hong, Su,Lee, Byung-Cheon,Nam, Chang-Hoon,Woo, Hee-Jong,Kang, Dae-In,Soh, Kwang-Sup KOREAN PHARMACOPUNCTURE INSTITUTE 2008 Journal of pharmacopuncture Vol.11 No.1
목적 : 봉한소체가 성체줄기세포의 원천이며, 봉한관이 줄기세포 수송로일 가능성을 확인함. 방법 : 쥐의 내부 장기표면에서 봉한소체와 봉한관을 채취했다. 다양한 줄기세포 표지항체를 써서 면역조직학적 분석을 했다. 결과 : mesenchymal 줄기세포에 관한 Integrin ${\beta}1$, Collagen type 1, Fibronectin의 강한 발현을 확인했다. CD54는 발현되지 않았다. 조혈줄기세포에 관련하여 Thy 1의 발현이 있었다. 결론 : 골수조직과 유사하게 mesenchymal과 조혈줄기세포의 표지가 BHC에서 확인되었고, 봉한관에서는 vWF가 발현되어 줄기세포 수송로 가능성을 확인했다. Objectives : Showing that Bong-Han corpuscles(BHC) are suppliers of the stem cells in adulthood, and the Bong-Han ducts(BHD) are transportation routes of stem cells. Methods : BHC and BHD were obtained from the internal organ-surfaces of rats. The sliced BHC and BHD were immunostained with various stem cell markers. Extracellular matrices were also analyzed by immunohistochemistry. Result : The presence of mesenchymal stem cells was confirmed by the expression of Integrin beta 1, Collagen type 1 and Fibronectin. But CD54 was not expressed. The hematopoietic stem cell marker, Thy 1 was strongly expressed. BHDs showed Collagen type 1, Fibronectin, and vWF expression. Conclusion : Both hematopoietic and mesenchymal stem cell markers were expressed strongly in BHC similarly as in bone marrow. An endothelial cell marker(vWF) demonstrated the possibility of the stem cell transportation routes of BHD.
다양한 노면 조건에서의 능동 긴급 제동 시스템(AEBS) 성능 해석 시뮬레이션
손민혁(Minhyuk Son),남창훈(Changhoon Nam) 한국자동차공학회 2012 한국자동차공학회 학술대회 및 전시회 Vol.2012 No.11
This paper presents the use of software tools that together provide the ability to cover critical aspects of active safety system design and performance analysis simulation. One of the software tools (PreScan) focuses on the design of the sensing and control systems, as well as the evaluation for a wide range of traffic and weather scenarios. Another software tool (CarSim) takes care of the detailed vehicle dynamics and has the function for external tire model and road profiles. For detailed the tireroad contact patch and tire forces, a Short Wavelength Intermediate Frequency Tyre (SWIFT) model has considered. A road profile model can generate by OpenCRG easily and coupled with the tire models in the CarSim. By means of an application example of an Active Emergency Braking System (AEBS) under rough road conditions, the combined use of those software tools to design and evaluate the performance of active safety system is demonstrated.
김요셉(Joseph Kim),범현균(Hyenkyun Beom),권성은(Sungeun Kwon),남창훈(Changhoon Nam) 한국자동차공학회 2009 한국자동차공학회 부문종합 학술대회 Vol.2009 No.4
Numerical simulation has played an important role in the vehicle development. Especially vehicle crash numerical simulations have been indispensable more and more in order to save the developing time and cost. However numerical simulation are usually deterministic. Crash tests results have scatter due to many variables such as manufactory condition of vehicle, test condition, margin for test procedures, slight deference of restraint system performance and so on. In order to consider these varieties under test situation, CAE based stochastic analysis has performed. In this paper, stochastic numerical simulations are carried out using MADYMO and ADVISER to investigate the variance of frontal EuroNCAP test results. In addition, influence of parameters on the result of frontal EuroNCAP tests are analyzed using stochastic post-processing tools. The results showed that EuroNCAP point varied from 9.7 to 11.1 according to calculation conditions and these value of bandwidth was 12 % of maximum point. In two cases, head bottoming out occurred.
과학기술자의 사회적 책임에 대한 이공계 대학생의 인식 탐색
고연주(Ko, Yeonjoo),심성옥(Shim, Sungok Serena),황요한(Hwang, Yohan),최유현(Choi, Yuhyun),옥승용(Ok, Seung-Yong),남창훈(Nam, Chang-Hoon),이현주(Lee, Hyunju) 한국공학교육학회 2022 공학교육연구 Vol.25 No.2
This study aimed to investigate the views of STEM college students on the social responsibility of scientists and engineers. A total of 660 students in STEM majors at several Korean universities participated in the study. We assessed social responsibility among college students in STEM majors using the VSRoSE scale, which taps into eight different domains of social responsibility: Concern for human welfare and safety (HUMAN), Concern for environmental sustainability (ENVIR), Consideration of societal risks and consequences (CONSEQ), Consideration of societal risks and consequences (CONSEQ), Consideration of societal needs and demands (NEEDS), Pursuit of the common good (COMGOOD), Civic engagement and services (CIVIC), Communication with the public (COMMU), and Participation in policy decision-making (POLICY). Group differences in social responsibility by gender, majors, and years in school were examined. Mean scores in HUMAN, ENVIR, and CONSEQ were relatively higher than those in NEEDS, COMGOOD, CIVIC, COMMU, and POLICY. Cluster analysis identified five different groups with similar patterns of social responsibility scores. In addition to two groups with overall high and low scores across all eight factors of VSRoSE, three additional groups with different combinations of high and low scores in different factors were identified. The results indicated that students with low social responsibility are not homogeneous and these heterogeneous sub-groups of students will need tailored interventions highlighting different factors of social responsibility that they lack. Pedagogical implications of social responsibility for education were discussed.