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박용덕,남동왕,성정민,황지민,김지현,이선경,안광식,유수민,조자원,문교태,이설훈,안재현 대한예방치과학회 2010 International Journal of Clinical Preventive Denti Vol.6 No.2
Objective: This experiment was contrived to find out the changed in oral condition index when standardized and regular use of the dentifrice is done according to the usage of dosage of the dentifrice. Methods: After inspecting the result of acceleration of collagen forming and suppressing effect of inflammatory reaction by using the titrated extracts of Centella asiatica and Dipotassium glycyrrhizinate with In-vitro experiment (done inside the lab), the remedying effect on oral cavity condition was to be obtained with dentifrice made with combined bamboo salt and those above through in-vivo experiment (clinical) worked with 90 healthy bodied examinees for over 6 months. Results: With the result of the experiment done at the lab, when the changes of improved index of oral cavity condition, MMP-1 formative inhibition analysis, and collagen analysis were obtained during the experiment periods, the titrated extract of Centella asiatica suppresses the damage of the tissue due to inflammatory response at the gingiva cell and after the inflammatory response, accelerated regeneration of the gingiva were clearly shown. Also, as with the result in clinical experiment, the effect was acceptable in reducing effect of dental plaque index and gingivitis index with dentifrice that only contains the titrated extract of Centella asiatica and also showed outstanding result in antibacterial activity. Conclusion: The most effective improvement especially shown on the oral conditions were dentifrice that contains Dipotassium glycyrrhizinate, bamboo salt and titrated extracts of Centella asiatica.
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