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윌슨병 환자에서 다발성 섬유선종을 동반한 거대유방증 1예
김훈혁,성기영,백종민,이도상,김욱,박일영,원종만,Hoon Hyuk Kim,M.D.,Gi Young Sung,M.D.,Jong Min Baek,M.D.,Do Sang Lee,M.D.,Wook Kim,M.D.,Il Young Park,M.D. and Jong Man Won,M.D. 대한갑상선-내분비외과학회 2004 The Koreran journal of Endocrine Surgery Vol.4 No.2
Wilson's disease is an autosomal recessive disorder of copper metabolism in individuals with mutant ATP7B genes. Impairment of normal excretion of hepatic copper results in toxic accumulation of the metal in liver, brain and other organs. Clinical manifestations include hepatic, neurologic or psychiatric disturbances. Penicillamine, as a chelator of copper, is the drug of choice in the treatment of Wilson's disease but after treatment of penicillamine, granulocytopenia, thrombocytopenia, the nephrotic syndrome, Goodpasture's syndrome, pemphigus vulgaris or pleural effusion may supervene. We report a case of macromastia with multiple fibroadenomas in a patient who was treated with penicillamine for Wilson's disease. (Korean J Endocrine Surg 2004;4:115-118)