하악골에 발생한 골막 골육종

김태우,김승범,권혁찬,문선재,윤정훈,김형준,차인호,육종인,김진 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Periosteal osteosarcoma is a distinct entity of malignant bone tumor with characteristic clinical, morphological, and histological features within the group of juxtacortical osteosarcoma. Periosteal osteosarcoma is predominantly located in the tubular long bones, and extremely rarely involving the jaws. A case of periosteal osteosarcoma of the right mandible is presented. A 27-year-old woman complained of the gingival swelling and bleeding tendency of the right posterior mandible. Clinical examination revealed a reddish brown strawberry-like swelling on the affected mucosa, which measured 1.5㎝×1.5㎝. The tumor was located on the lingual cortex of the mandible and extended into the surrounding soft tissues. Microscopically, the tumor consisted exclusively of atypical chondroblastic cells with a small osteoblastic area. A minimal bone marrow involvement was noted and the adjacent cortex was free of tumor. These findings suggested that the tumor originated from the periosteal cambium layer, which lies between the periosteal fibrous layer and the cortex of mandible.

중간뇌 중심회색질에서 Calbindin-D_(28K)의 신경해부학적 표지성

김상훈,장혁진,이진 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Purpose: We investigated whether the calbindin-D_(28K) (CB) immunoreactivity could be available as a neurochemical marker to identify different anatomical subdivisions in the midbrain periaqueductal gray (PAG) of laboratory animals. Materials and Methods: Immunohistochemistry for CB and histochemistry for cytochrome oxidase (CO) were carried out on coronally-sectioned midbrain slices of five species of animals including mice, hamsters, rats, rabbits and guinea pigs. Results: In the rat PAG, at the level of nucleus of trochlear nerve, CB immunoreactive perikarya and plexus of fibers were localized in three band-like areas including dorsolateral PAG (DL), the ventral part of lateral PAG (Lv) and the supraoculomotor cap nucleus (Su3C). The similar pattern in the distribution of CB immunoreactivity was noticed also in the rabbit and the guinea pig PAG at the corresponding level, with three areas of DL, Lv and the ventral part of ventrolateral PAG. In all the 5 species of animals, Su3C was readily marked with clusters of CB-immunoreactive perikarya and fibers. In the comparison between the CB-immunoreactivity and the CO activity in the PAG, CB-immunoreactive areas were coincidided with areas of the low CO activity. Conclusion: The present data suggest that the CB immunoreactivity can be regarded as a reliable neurochemical marker for the specific areas within the midbrain PAG.

충주시 고등학생의 최근 4년간(1988-2001) B형간염 표면항원 및 항체 양성률 조사

김형수,이건세,장성훈,박수경,김청식,이창희,권혁중,정순섭 한국역학회 2002 Epidemiology and Health Vol.24 No.2

Objective : Since Korea has been known to be of the endemic area for hepatitis B virus(HBV) infection, vaccination for HBV has been recommended for all neonates in Korea. After starting vaccination in 1983, the change of sero-positivity of HBsAg and HBsAb is expected. This study was carried out to investigate the seropositive rate of hepatitis B virus surface antigen and antibody in high school freshmen students in Chungju-city. Methods and Materials : From 1998 to 2001, a total of 11,735 who were born in 1982 to 1986, were enrolled in this study. HBsAg and anti-HBs were tested by reversed passive hemagglutination and passive hemagglutination, respectively. Results : The study population was 11,735 students who were composed of 5,813 males (49.6%) and 5,914 females (50.4%). The HBsAg sero-positivity of male and female students was 3.25% (n=381) and 2.59% (n=153) respectively. The anti-HBs sero-positivity of male and female students was 62.2% (n=3,154) and 64.1% (n=2,969) respectively. There are significant difference observed in comparison of HBsAg and anti-HBs seropositivity according to sex (p<0.05). From 1982 to 1986 on birth year, anti-HBs sero-positivity has been increased significantly from 63.3% to 73.3%. But the change of HBsAg sero-positivity has not been changed significantly. Conclusions : As compared with previous studies of HBsAg and anti-HBs, the sero-positive rate of HBsAg has not been changed but that of HBsAb has been increased significantly. This result revealed that the effect of HBV vaccination program was successful.

치성낭종으로부터 유래된 편평상피세포암종 : Report of a Case & Review of Literatures

권혁진,현재훈,박형국,김용각 大韓顎顔面成形再建外科學會 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.2

Odontogenic cysts are relatively common pathologic lesions found in the oral and perioral structures, but the case of squamous cell carcinoma arising from those cysts are very uncommon. After first reported of that case in 1889 by Herman, Schwimmer collected 56 cases of previously reported squamous cell carcinoma arising in residual odontogenic cyst during about past one century. More than 60% of cases of carcinoma developing in odontogenic cysts arising in inflammatory periapical or residual cyst, and these tumors are usually well-differentiated with relatively good prognosis, and often are diagnosed as benign lesion in radiographic or clinical examination, therefore definitive diagnosis must be made by histologic examintation. We report a case and review the literatures, in our case, 78-year old woman were clinically and radiographically diagnosed as residual odontogenic cyst. But in histologic examination after enucleation of lesion, mass of squamous cell carinoma were observed, but in other area, typical cyst wall and lining epithelium were observed. And in some area, carcinoma in situ and invading squamous cell carcinoma into the lining epithlium were also observed.

PCA와 ANN을 이용한 VOC 측정기기 개발

이장훈,권혁구,박승호,김동진,홍철호 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.2

Air quality monitoring is a primary activity for industrial and social environment. The government identifies the pollutants that each industry must monitor. Especially, the VOCs(Volatile Organic Compounds), which are very harmful to human body and environment atmosphere, should be controlled under the government policy. However, the VOCs, which have not been confirmed in emission sources are very difficult to monitor. It is needed to develop the monitoring system that allow the continuous and in situ measurement of VOCs mixture in different environmental matrices. Gas chromatography and mass spectrometry are the most prevalent current techniques among those available for the analysis of VOCs. But, they need a large size analytical instrument, which costs a great deal for purchase and operation. In addition, it has some limitations for real time environmental monitoring such as location problems and slow processing time. Recently, several companies have commercialized a portable VOCs measurement systems, which cannot classify various kinds of VOCs but total quantities. We have developed a VOCs measurement system, which recognizes various kinds and quantities of VOCs, such as benzene, toluene, and xylene(BTX). Also, it can be used as a stand-alone type and/or fixed type in the vehicle with rack for real-time environmental monitoring.

정신과 문제로 병사용 진단서를 발급받은 환자들의 임상적 특징

장혁진,김학렬,박상학,김상훈,조용래,표경식 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Most Korean young men should take a military physical examination. This study attempted to search the social, economical and psychological features of Korean youths who have psychiatric problems in taking the military physical examination. So this study was intended to help decide whether the youths enter the military service or not. Materials and Methods : This study analyzed diagnostic features that were grouped by 7 categories (antisocial and borderline personality disorder group, the other personality disorders group, psychosis group, organic mental disorder group, neurosis group, pervasive developmental disorders group, the other groups). The study was conducted from 1994 to May 1999 at Chosun University hospital with about 143 patients who were issued the psychiatric certificate for military affairs. Results : According to the results of the psychiatric examination, the antisocial and borderline personality disorder group had increased more year by year than the other groups. Classified by the residential distribution, the residents of agricultural areas belonged to the psychosis group more than others. Classified by the job distribution, the antisocial and borderline personality disorder group had more gangsters than the other groups. Also the pervasive developmental disorders group included those Who were without an occupation. Classified by visiting companion, those who were included in the antisocial and borderline personality disorder group and pervasive developmental disorders group used to come alone as compared with the other groups. In the case of those who have experienced psychiatric treatment in the past and who have been treated psychiatrically after being given the psychiatric certificate, the psychosis group comprised more than 50% statistically. In the case of the existence of a tattoo and self-injured scars, the antisocial and borderline personality disorder group has more than the others statistically. According to psychological examination, by measure of validity scale of MMPI, the antisocial and borderline personality disorder group appeared as the inverted V shape that L, K value was low and F value was high. And the antisocial and borderline personality disorder group measured by the Pd, Pa measure. Pd, Pa measure value got higher points than the organic mental disorder group statistically. Conclusion : The number of the antisocial and borderline personality disorder patients’ visits increased at the psychiatric hospital year by year and there were many gangsters or persons without regular occupation in that kind of patients’group. And there were many visitors who came by themselves to the hospital. Also they tended to have a tattoo or self-injured scars. And most of patients didn’t do commuting psychiatric care after receiving the psychiatric certificate. In the aspect of the psychological examination, they were likely to exaggerate their symptoms or disguise having psychiatric trouble intentionally.

혈소판감소증 : 임산부 및 신생아 중심으로

이창훈,권혁중,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

It is important to distinguish from physiologic incidental thrombocytopenia (IP) in pregnant women and pathologic thrombocytopenic conditions associated with pregnancy involving pre-eclampsia/eclampsia, HELLP syndrome/AFLP, TTP/HUS, DIC, and infectious diseases. And also, they should be differentiated from ITP, SLE, and drug-induced thrombocytopenia which are immunologic disorders. Although neonatal thrombocytopenia in most cases occurs from non-immune mediated dise-ases or pregnancy-induced thrombocytopenic conditions, but rarely, neonatal alloimmune thr-ombocytopenia (NAIT) which was caused by fetomaternal mismatch for human platelet all-oantigen (HPA) can occur.

일 대학병원에 입원한 주요우울장애의 증상 특성

이진,김상훈,김학렬,박상학,황걸,장혁진 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Objectives: The purpose of this study was to investigate the frequency and kinds of symptoms and the profile of depressive symptoms and somatic symptoms of admitted patients with major depressive disorder in a university hospital. Methods: The study was cross-sectional study in Chosun university hospital. A total of 299 patients who met the diagnostic criteria of major depressive disorder according to DSM-IV were participated in this study. Forty four item questionnaires were developed to check symptoms and the questionnaires checked from patient's medical record. Results: Common depressive symptoms were the following order: depressive mood (55.2%), initial insomnia (52.8%), anxious/tense (47.8%), tired/no energy (35.1%), suicidal ideation (28.8%). Common somatic symptoms were the following order: decreased appetite (33.1%), headache (22.1%). gastric discomfort (16.7%), palpitation (15.4%), chest discomfort (11.4%). Comparing depressive symptoms and somatic symptoms in terms of gender, anxious/tense, emotional/cry a lot, decreased appetite, gastric discomfort, palpitation, were more frequent in female patients (p<0.05), On the other hand, interpersonal sensitivity, pessimism were more frequent in male patients (p<0.05). Elderly depressed patients showed hypochondriasis symptom more frequently than younger patients (p<0.05). Conclusion: These results suggested that the depressive symptoms showed dissimilar in character according to the gender and age. Therefore proper diagnostic and therapeutic approaches will be needed for each patient's symptom characteristics.

Flowable 및 microfill 복합레진으로 충전된 제 5급와동에서 load cycling 전,후의 미세변연누출 비교

강석호,김오영,오명환,조병훈,엄정문,권혁춘,손호현 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.2

Low-viscosity composite resins may produce better sealed margins than stiffer compositions (KempScholte and Davidson, 1988; Crim, 1989). Flowable composites have been recommended for use in Class V cavities but it is also controversial because of its high rates of shrinkage. On the other hand, in the study comparing elastic moduli and leakage, the microfil had the least leakage (Rundle et al. 1997). Furthermore, in the 1996 survey of the Reality Editorial Team, microfills were the clear choice for abfraction lesions. The purpose of this study was to evaluate the microleakage of 6 composite resins (2 hybrids, 2 microfills, and 2 flowable composites) with and without load cycling. Notch-shaped Class V cavities were prepared on buccal surface of 180 extracted human upper premolars on cementum margin. The teeth were randomly divided into non-load cycling group (group 1) and load cycling group(group 2) of 90 teeth each. The experimental teeth of each group were randomly divided into 6 subgroups of 15 samples. All preparations were etched, and Single bond was applied. Preparations were restored with the following materials (n=15) : hybrid composite resin [Z250(3M Dental Products Inc. St.Paul, USA), Denfil(Vericom, Ahnyang, Korea)], microfil [Heliomolar RO(Vivadent, Schaan, Liechtenstein), Micronew(Bisco Inc. Schaumburg, IL, USA)], and flowable composite[AeliteFlo(Bisco Inc. Schaumburg, IL, USA), Revolution(Kerr Corp. Orange, CA, USA)]. Teeth of group 2 were subjected to occlusal load (100N for 50,000 cycles) using chewing simulator(MTS 858 Mini Bionix Ⅱ system, MTS Systems Corp., Minn, USA). All samples were coated with nail polish 1mm short of the restoration, placed in 2% methylene blue for 24 hours, and sectioned with a diamond wheel. Enamel and dentin/cementum margins were analyzed for microleakage on a sclale of 0 (no leakage) to 3 (3/3 of wall). Results were statistically analyzed by Kruskal-Wallis One way analysis, Mann-Whitney U-test, and Student-Newmann-Keuls method. (p=0.05) Results: 1. There was significantly less microleage in enamel margins than dentinal margins of all groups. (p<0.05) 2. There was no significant difference between six composite resin in enamel margin of group 1. 3. In dentin margin of group 1, flowable composite had more microleakage than others but not of significant differences. 4. There was no significant difference between six composite resin in enamel margin of group 2. 5. In dentin margin of group 2, the microleakage were R>A=H=M>D>Z. But there was no significant differences. 6. In enamel margins, load cycling did not affect the marginal microleakage in significant degree. 7. In dentin margins, load cycling did affect the marginal microleakage only in Revolution. (p<0.05)

상아질 접착제의 중합 시간 조절에 따른 복합레진의 중합 수축 방향의 변화

배지현,오명환,김창근,손호현,엄정문,조병훈,권혁춘 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.4

The purpose of this study was to evaluate the effect of adhesive curing timing on the direction of polymerization shrinkage of light-curing composite resin. In this study, the curing times of adhesive and composite resin were measured by differential scanning calorimeter(DSC). 28 extracted human molars were embedded in clear resin and box-type cavities were prepared. Based on DSC data. the experimental teeth were divided into 4 groups. Group 1: no bond: Group 2: late curing: Group 3: Intermediate curing: Group 4: Early curing. After treating with adhesive, the buccal cavities were filled with Z-100 hybrid composite resin and the lingual ones were filled with AEliteflo flowable composite resin. The depressions at the surface were measured by surface profilometer, then the specimens were embedded in clear resin and sectioned. Impressions were obtained and used to get epoxy resin replicas. The epoxy replicas were gold-coated and observed under SEM. Average Maximum Gap(AMG), Gap Proportion(GP), Average Marginal Index(AMI) were used to compare the shrinkage gap of each group. The results were statistically analyzed using the Kruskal-Wallis One Way ANOVA, Student-Newman-Keuls method. The results of this study were as follows. 1. Average Maximum Gap. Gap Proportion, Average Marginal Index and depression at the surface of Z-100 hybride composite resin were smailer than those of AEliteflo flowable composite resin(P(0.05) 2. When the bonding between composite resin and tooth structure was strong, the shrinkage gap was small, and depression at the surface was deep(P<0.05). 3. In the well-bonded group. light-curing composite resin shrank toward bonded cavity wall. not toward light source. The result suggested that the direction of polumerization shrinkage was affected by the quality of bonding in the dentin-resin interface. The strong was the bonding between composite resin and tooth structure, the smaller was the gap and the deeper was the depression at the surface. Then the flow to compensate the polymerization shrinkage proceeded from surface to bonded cavity wall.