http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김정상(Jong-Sang Kim) 한국식품영양과학회 1994 한국식품영양과학회지 Vol.22 No.6
One of the major problems of cancer chemotheraphy is the development of drug resistance in tumors, resulting in reduced responsiveness to subsequent treatments. The folate antagonists are being used to treat such diverse illnesses as cancer, leukemia, psoriasis, rheumatoid arthritis, etc. Previous studies have established that resistance to antifolates may occur in mammalian tumor cells by one or more of five mechanisms : (a) an increase in the levels of the target enzyme, generally as a consequence of gene amplification; (b) an alteration in the target enzyme, leading to an enzyme with a decreased binding affinity for the drug; (c) a decrease in the uptake of the drug into the cells; (d) increased extrusion of drugs out of cells; (e) impaired ability to polyglutamylate the parent drug which is capable of being intracellularly metabolized to longer chain length.
면역세포화학적 방법을 이용한 고양이 중간뇌에서 Calbindin D-28k 와 Parvalbumin을 함유한 GABA의 분포상에 관한 연구
김종중(Jong-Joong Kim),정상봉(Sang-Bong Jeong),김남훈(Nam-Hoon Kim),안계훈(Gye-Hoon Ahn),정윤영(Yoon-Young Chung),문정석(Jeong-Seok Moon),장인엽(In -Youb Chang),김홍순(Hong-Soon Kim) 대한체질인류학회 2000 대한체질인류학회지 Vol.13 No.2
간추림 고양이 중간뇌에서 calbindin D-28k (CB) 와 parvalbumin (PV), 그리고 gamma-aminobutyric acid (GABA) 의 분포상과 세포의 형태 및 크기를 관찰하고, 동일세포 E 안에서 이들의 공존을 확인하기 위하여 본 실험을 시행 하였다. CB, PA 및 GABA 에 대한 특이성을 지난 단세포군항체를 이용한 면역세포화학적 염색을 하여 관찰한 결과 다음과 같은 결론을 얻었다. 1 적색핵, 흑색질, 눈돌림신경핵, 청색핵에서 CB-IR, PV-JRGABA-IR 세포를 가장 많이 관찰할 수 있었다. 2 적색핵에서는 PV-IR 세포가, 흑색질에서는 CB-IR 세포가 더 많이 출현하였다. 3. PV-IR 과 GABA-IR 이 통일세포에 공존하는 것을 관찰할 수 있었다. 4. CB-IR, PV-IR, GABA- IR 세포의 세포체의 형태는 방추형, 타원형, 원형이었고 그 크기는 15-20 μm 이었으며 세포의 모양을 흩극, 이극, 뭇극신경원이었다.
5-Fluorouracil이 생쥐의 간에 미치는 세포독성에 대한 Squalene의 영향
김정상,김재성,박정석,최완수,최영복,김종세,Kim, Jeong-Sang,Kim, Jae-Sung,Park, Jung-Suk,Choi, Wan-Soo,Choi, Young-Bok,Kim, Jong-Se 한국현미경학회 1997 Applied microscopy Vol.27 No.2
This paper aims to prove the effects of Squalene (SQ) on the cellular toxicity of 5-FU to the mouse which pretreated with SQ and then treated with 5-FU. The results of the group A (treated with only 5-FU) are as follows. The nucleus was destroyed at 24 hours and 48 hours group, however, somewhat repaired at 72 hours group. The dilated inner cavity and the irregular lamellae of the rough surfaced endoplasmic reticulum (RER) were observed continually until 72 hours group. The inner cavity of the smooth surfaced endoplasmic reticulum (SER) were dilated in all groups. However, the destroyed and the normal membrane were observed simultaneously at 72 hours group. The inner membrane of the mitochondria were almost repaired at 96 hours group. The results of the group B (treated with 5-FU and squalene) are as follows. The nucleus was a little influenced by the toxicity of 5-FU at 24 hours and 48 hours, RER were observed to keep the typical lamella structure of cisternae from 24 to 72 hours group, but inner cavity kept on dilating. In SER, inner cavity were also observed to flatten from 24 to 72 hours group. Mitochnodria were always shown normal. All cell organelles were simillar to those of normal groups at 96 hours. Accordingly, it can be said that the treatment of 50 prevents the cytotoxicity of 5-FU on cell organelles of liver cell and that is concerned with the formation of membrane system of cell organelles.
머신 비젼 시스템을 이용한 세탁기 밸런스 방향 인식에 관한 연구
김광호(Gwang-Ho Kim),김종태(Jong-Tae Kim),김태호(Tae-Ho Kim),박진완(Jin-Wan Park),김재상(Jae-Sang Kim),정상화(Sang-Hwa Jeong) 한국기계가공학회 2009 한국기계가공학회지 Vol.8 No.2
When washing machine is rotated in the laundry, it tends to lean toward one side. This tendency causes a serious vibration. The balance of washing machine plays an important role in order to reduce the vibration by injecting the sand or the salt water into the balance of washing machine. The hot plate welder is used to prevent from outflow of contents. The hot plate welder brings about many problems which is concerned with accidents. The direction recognition and location information of the balance are required in this system. In this paper, the recognition direction of balance in washing machine using machine vision system is studied. The template matching algorithm compares sub-image with original image acquired in real-time to obtain a center point of balance image. The mid points and the edges of balance are estimated by the edge detection and gauging algorithms. The data acquired by these results is used for recognition direction of balance. The automation software for image processing is developed by using LabVIEW.
Adriamycin으로 유발된 생쥐의 간독성에 대한 Squalene의 영향
김정상,최영복,김종세,Kim, Jeong-Sang,Choi, Young-Bok,Kim, Jong-Se 한국현미경학회 1997 Applied microscopy Vol.27 No.1
The objective of the present study was to investigate the cytotoxicity of adriamycin in liver cells (group A), and the protective effect of squalene to the hepatocytes to which adriamycin-induced cytotcxicity (group B) was examined by transmission electron micro-scope. In the group A, The cisternae of rough endoplasmic reitculum and smooth endoplasmic reticulum are dilated/disoriented at 24 hours and 48 hours. The inner and outer membrane of mitochondria are detached or destructed , and attached ribosomes of rough endoplasmic reticulum are diminished in number. The cisternae of the smooth endoplasmic reticulum are dilated, and the cristae of mitochondria are disrupted at 72 hours and 96 hours. In the group B, the cisternae of the rough endoplasmic reticulum and smooth endoplasmic resticulum are dilated at 24 hours. The cisternae of the smooth endoplasmic reticulum are dilated at 48 hours. The cell organelles of hepatocytes are recovered from cytotoxicity at 72 hours. These results suggest that 50 is not only concerned with composition of the membrane system of the cell organelles but also decreased the cytotoxicity of the hepatocytes.