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RISS 인기검색어
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- 저자 : 김장연(Jang Yeon Kim) (검색결과 4 건)
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김장연(Jang Yeon Kim),이동근(Dong Keun Lee) 대한구강악안면외과학회 1997 대한구강악안면외과학회지 Vol.23 No.3
The purpose of this study was to evaluate the relationship between proliferation and cell death during oral carcinogenesis. Syrian golden hamsters which were 3 month old and 90-120 gm-weight were used in this study. The 9, 10-dimethyl -1,2-benzanthracene(DMBA) in a 0.5% solution in mineral oil was painted on the buccal pouch mucosa 3 times per week in the experimental group during 20 weeks. Control group was painted with mineral oil. In each control and experimental group of 6, 8, 10, 12, 14, 16, 18, 20 weeks, specimen were sectioned for immunohistochemical study with ant1-Proliferating Cell Nuclear Antigen(PCNA), anti-transglutaminase transglutaminase and GST-π were obtained by counting the positive cells to those antibodies. The following results were obtained. 1. Histopathologically, finding of epithelial dysplasia of the 6 and 8 weeks experimental group and carcinoma in situ in the 12 weeks and squamous cell carcinoma in those of the 14 weeks were seen. 2. PCNA positive cells were mainly mild expressed in the basal cell layer of normal oral mucosa, increased moderately, after 6 weeks. In suprabasal cell layer, control group is negative but retained moderately between 6 weeks and 14 weeks, and decreased after 16 weeks. In spinous cell layer, restricted only between 12 weeks and 16 weeks, other period is mild or negative. 3. PCNA Index of expermental group revealed the increased peak in 6 weeks and 20 weeks than control group, and retained between 12 weeks and 18 weeks. All experimental group expressed higher PCNA Index than control group(P.<0.05). 4. Tranglutaminase expression was localized in outer and suprabasal layers on control group, but after 6 weeks, expression site moved spinous & suprabasal cell layers, and after 8 weeks, expression is spreaded to basal cell layer, and this pattern retained to 20 weeks. Transglutaminase expression of experimental group was higher than control group after 8 weeks. 5. The positive staining of detoxifying agent, Glutathione S-Transferase(GST)π of experimental group was radually increased from 6 weeks. After 10 weeks, all layer of experimental group was seen positive reaction. The strong positive staining in center of tumor and weak positive staining in periphery of tumor were seen at the stage of squamous cell carcimoma in 14 weeks. According to the results, we should suggest that the more increased proliferation of tumor cell, the more increased expression of PCNA, transglutaminase and GST-n as a detoxifying agent during carcinogenesis by induced DMBA were seen.
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자가 및 동종이연골을 이용한 가토 하악 관절원판재건에 관한 연구
김종구(Jong Goo Kim),김수남(Soo Nam Kim),이동근(Dong Keun Lee),김장연(Jang Yeon Kim),이재은(Jae Eun Lee) 대한구강악안면외과학회 1994 대한구강악안면외과학회지 Vol.20 No.2
Autogenous cartilage grafts are recently used in plastic and reconstructive surgery, especially auricular cartilage grafts are widely used in replacement of temporomandibular joint disc. Cartilage grafts itself has a high survival rate after grafting and I needs a low metabolic rate. We compared the viability, adhesion and foreign body reactions with the autogenous or allogeneic auricular cartilage grafts in cases of disc resection in rabbit temporomandibular joint. Routine histopathologic findings has performed at 1, 2, 4, 6 and 8 weeks postoperatively. The results were: 1. Grafted auricular cartilage in articular disc was surrounded by fibrous tissue without bone resorption or new bone formation. Inflammatory findings and hemorrhages were more prominent in allogeneic groups than in autogenous groups at 1 and 2 weeks, but after 4 weeks each group had no differences. 2. Degeneration of grafted auricular cartilage was prominent in II allogeneic groups till 2 weeks, but after 4 weeks each group had no differences. 3. Vascular proliferations and fibroblastic proliferations around the grafted auricular cartilage showed more activities in autogenous groups than allogeneic groups at 1, 2 and 4 weeks. 4. Much more additional growth of the marginal area of the grafted auricular cartilage was revealed in autogenous groups at 1, 2 and 4 weeks respectively.
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강민욱(Kang, Min-Uk),강도연(Kang, Do-Yeon),김장석(Kim, Jang-Seok) 한국주거학회 2018 한국주거학회 학술대회논문집 Vol.30 No.2
The purpose of this study is to look at how earthquakes can affect our lives through an earthquake in Heunghae-eup, Pohang, and what direction we should deal with. The analysis data were obtained by visiting the destination and Pohang Ctiy Hall. A status analysis and analysis of earthquake-damaged structures and seismic design were conducted on Seongnae-ri, NamSeong-ri, JungSeong-ri, Yakseong-ri, Hakseong-ri, Masan-ri, and Okseong-ri in the downtown area. The results show that 76 of the 536 buildings were damaged, the most damaged at 14.18%, and that there are many buildings that do not meet the seismic design standards.
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김장연,김영조,엄인웅,이동근,이재은 大韓顎顔面成形再建外科學會 1993 Maxillofacial Plastic Reconstructive Surgery Vol.15 No.3
Many surgeons are on the point of bone excision and reconstruction of the bone defects by autograft. xenograft, and allograft in the treatment fo begin and malignant tumors of bone. Of all type of bone grafts, we received the autograft as the best ideal bone graft. Of autogenic bone graft, replantation of excised autogenic bone for reconstructiong the bone defects has been the ideal method until now, but early bone healing reponses and tumor cell devitalization after replantation of excised autogenic bone have not been identified for clinical applications. So, to evaluate bone healing response after replantation in rabbit's calvarial bone, we divided the experimental group into three groups. Group 1 is a fresh autogenous bone group. Group 2 is a deep frozen group. Group 3 is freeze-dried demineralized group. Obtained result were as followed: 1. Inflammatory cell infiltration appeared at I week and disappeared at 4 weeks in all experimental group, Especially, severe inflammatory cell infiltration showed in fresh autogenous bone group at 2 weeks, Especially, severe inflammatory cell infitration showed n fresh autogenous bone group at 2 week Group 3 is the least showing group on the point of inflammatory cell infiltration. 2. Osteoblastic activity evenly increased upto 4 weeks and maintained to 6 weeks and decreased after this period, especially osteoblastic activity in group 2 is less than group 1 and group 3. We can't discriminate between osteoblastic activity of group 1 and that of group 3. 3. In new bone formation, group 3 was more active than any other groups at early stage, but there were little differences among three experimental groups at later state. 4. Bone resorption around the grafted bone slightly appeared at 1 week and disappeared at 4 weeks in all experimental groups. We can find the more bone resorption in group 2 at 2 weeks than any other groups. We could suggest, as appears from our results, that freeze-dried deminiralized bone graft is the useful bone graft in the clinical applications of excised autogenic bone.
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