중심각막두께 측정에 대한 파장가변 빛간섭단층촬영계의 유용성

김임규(Im Gyu Kim),이종은(Chong Eun Lee),이준석(Jun Seok Lee),서 샘(Sam Seo),이규원(Kyoo Won Lee) 대한안과학회 2016 대한안과학회지 Vol.57 No.10

목적: 파장가변 빛간섭단층촬영계(swept source optical coherence tomography, SS-OCT)로 측정한 중심각막두께를 초음파 각막두께측정계(ultrasound pachymetry), Orbscan II, 전안부 빛간섭단층촬영계(anterior segment optical coherence tomography, AS-OCT)로 측정한 중심각막두께와 비교하여 SS-OCT의 임상적 일치율의 유용성을 알아보고자 하였다. 대상과 방법: 한 명의 검사자가 65명 65안의 정상안을 대상으로 Orbscan II, AS-OCT, SS-OCT, 초음파 각막두께측정계의 순서로 중심각막두께를 측정하여 상관관계를 비교, 분석하였다. 결과: Orbscan II, AS-OCT, SS-OCT와 초음파 각막두께측정계를 이용하여 측정한 각각의 평균 중심각막두께는 각각 534.83 ±38.46, 517.80 ± 32.48, 528.22 ± 33.71, 528.02 ± 34.90 μm였다. 4가지 검사기기에서 높은 상관관계를 보였으며(r>0.894, p<0.001 in all groups), SS-OCT와 초음파 각막두께측정계를 이용한 측정치에서 통계적으로 유의한 일치율을 보였다(p=0.782). 결론: 정상인에서 SS-OCT로 측정한 중심각막두께가 초음파 각막두께측정계로 측정한 값에 높은 일치율을 보여, 정상인의 중심각막두께 측정에 SS-OCT가 초음파 각막두께측정계를 대체할 수 있는 유용한 방법이라 생각된다. <대한안과학회지 2016;57(10):1542-1548> Purpose: To evaluate the efficacy of swept source optical coherence tomography (SS-OCT) by comparing the measurement of central corneal thickness (CCT) to the measurement obtained using Orbscan II, anterior segment optical coherence tomography (AS-OCT) and ultrasound pachymetry. Methods: One examiner measured the CCT in 65 eyes of 65 healthy subjects using Orbscan II, AS-OCT, SS-OCT and ultrasound pachymetry. The mean values and correlations were analyzed. Results: The average CCT measurements obtained using Orbscan II, AS-OCT, SS-OCT and ultrasound pachymetry were 534.83 ± 38.46, 517.80 ± 32.48, 528.22 ± 33.71 and 528.02 ± 34.90 μm, respectively. A significant linear correlation was observed among Orbscan II, AS-OCT, SS-OCT and ultrasound pachymetry (r > 0.894, p < 0.001). There was no significant difference between the SS-OCT and ultrasound pachymetry (p = 0.782). Conclusions: The results of the 4 methods were significantly correlated and the SS-OCT reached a high level of agreement when CCT was determined using ultrasound pachymetry. The CCT measurements using SS-OCT is a better alternative for ultrasound pachymetry than Orbscan II and AS-OCT. J Korean Ophthalmol Soc 2016;57(10):1542-1548

나이관련황반변성에서 라니비주맙과 애프리버셉트 후 맥락막두께의 변화 비교:

김임규(Im Gyu Kim),김용일(Yong Il Kim),김진선(Jin Seon Kim),이정호(Jung Ho Lee),이규원(Kyoo Won Lee),강현구(Hyun Gu Kang) 대한안과학회 2017 대한안과학회지 Vol.58 No.3

목적: 삼출성 나이관련황반변성 환자에서 유리체강내 애프리버셉트와 라니비주맙 주입술 후 맥락두께의 변화를 비교해 보고자 한다. 대상과 방법: 삼출성 나이관련황반변성 환자 중 1개월 간격으로 3회 애프리버셉트 또는 라니비주맙 주입술 후 필요할 때마다 추가 주사를 하면서 6개월 이상 경과관찰한 50명 53안을 대상으로 후향적으로 분석하였다. 스펙트럼영역 빛간섭단층촬영을 이용하여 주사 전, 첫 번째 주사 후 1개월, 2개월, 3개월, 6개월에 황반하 맥락막두께를 측정하여 변화를 연구하였다. 결과: 황반하 맥락막두께는 애프리버셉트 주입군(25안)에서 주사 전과 첫 번째 주사 후 1개월, 2개월, 3개월, 6개월에 각각 244.94 ± 103.77 μm, 219.04 ± 95.89 μm, 208.74 ± 91.03 μm, 203.64 ± 91.35 μm, 226.98 ± 96.79 μm였으며, 라니비주맙 주입군(28안)에서는 222.68 ± 102.04 μm, 210.23 ± 95.91 μm, 203.66 ± 99.39 μm, 197.27 ± 100.25 μm, 210.32 ± 111.86 μm였다. 황반하 맥락막두께의 변화량은 첫 번째 주사 후 1개월, 2개월, 3개월에 애프리버셉트 주입군이 라니비주맙 주입군보다 의미있게 더 많이 감소 하였으며(p<0.05), 6개월에는 두 군 간에 의미 있는 차이는 없었다(p>0.05). 결론: 매달 3회 연속 주사 중에는 애프리버셉트 주입군에서 라니비주맙 주입군보다 황반하 맥락막두께가 더 많이 감소하였으나, 치료시작 6개월 후에는 의미있는 차이는 없었다. Purpose: To compare the changes in subfoveal choroidal thickness between intravitreal aflibercept and ranibizumab injection in wet age-related macular degeneration (AMD). Methods: Fifty patients with wet AMD patients who were treated with aflibercpet or ranibizumab were evaluated retrospectively. All patients were treated with pro re nata after 3 consecutive monthly injections and were followed up for at least 6 months. We measured subfoveal choroidal thickness (SFCT) using enhanced depth imaging spectral-domain optical coherence tomography before the first injection and 1, 2, 3, and 6 months after initial injection. Results: The SFCT measures before initial injection and 1, 2, 3, and 6 months after initial injection were 244.94 ± 103.77 μm, 219.04 ± 95.89 μm, 208.74 ± 91.03 μm, 203.64 ± 91.35 μm, and 226.98 ± 96.79 μm in the aflibercept group (25 eyes) and 222.68 ± 102.04 μm, 210.23 ± 95.91 μm, 203.66 ± 99.39 μm, 197.27 ± 100.25 μm, and 210.32 ± 111.86 μm in the ranibizumab group (28 eyes). Mean change in SFCT was greater in the aflibercept group at 1 month, 2 months, and 3 months after initial injection (p < 0.05), but there was no significant difference in the mean change in SFCT between the two groups at 6 months after initial injection (p > 0.05). Conclusions: The decrease in SFCT was greater after aflibercept injection than ranibizumab injection in 3 consecutive months. However, at 6 months after initial injection, the difference in the change in SFCT was not significant.

자살 임박 시기 알코올 사용과 자살 기도의 특성

김임규(Im-Gyu Kim),임지섭(Ji-Seop Lim),공보금(Bo-Geum Kong),강제욱(Je-Wook Kang),문정준(Jung-Joon Moon),전동욱(Dong-Wook Jeon),김성진(Sung-Jin Kim),김현정(Hyun-Jung Kim),정도운(Do-Un Jung) 대한생물치료정신의학회 2016 생물치료정신의학 Vol.22 No.1

Objective:The aim of this study was to analyze the clinical characteristics of individuals who used alcohol at the time of attempting suicide. Methods:We divided 143 individuals who attempted suicide by consuming drugs into two groups on the basis of their blood alcohol concentration level: drinker group(n=79) and non-drinker group(n=64). We compared epidemio¬logical characteristics and suicidal behavior between the groups by using the Suicidal Intent Scale(SIS) and the Risk Rescue Rating Scale(RRRS). In addition, we administered the Glasgow Coma Scale(GCS) and the Acute Physiology and Chronic Health Evaluation-II(APACHE-II) to evaluate the medical lethality of the individuals who attempted sui¬cide. We used Student’s t-test, Pearson’s correlation analysis, and multiple linear regression to analyze the data. Results:The drinker group scored lower on the SIS’s planning subscale than the non-drinker group did(p=0.022). The drinker group’s blood alcohol concentration levels were negatively correlated with the rescue potential of their suicidal attempt(p=0.031) and the APACHE-II score(p=0.003). Higher blood alcohol concentration levels predicted poorer medical outcomes measured by the APACHE-II(p=0.004). Conclusion:Our findings support the notion that alcohol use increases suicidal impulsivity, decreases rescue po¬tential, and worsens medical outcomes. Therefore, suicide prevention programs need to include education and counseling about the risks associated with alcohol use.

가야산국립공원 까막딱다구리의 번식 현황

권영수,전세근,설정욱,김임규,Kwon, Young Soo,Jeon, Se Kun,Seol, Jeong Wook,Kim, Im Gyu 강원대학교 산림과학연구소 2012 Journal of Forest Science Vol.28 No.4

This study was conducted from April 2012 to June 2012 to analyze breeding status of Black woodpeckers (Dryocopus martius) in the Gayasan National Park. Nest height, tree diameter which a nest built and altitude at the nest site of Black woodpeckers were 17.4 m, 63.8 cm and 587 m, respectively. A pair of Black woodpeckers completed a clutch in 4 eggs on 7 May and 3 of eggs hatched on 24 May 2012. Both female and male incubated eggs and never left eggs without one of parents. A male more contributed to build a nest than a female. Incubation duration was higher in a male than in a female. Nestlings made a begging call in a nest during the growing period. Begging frequency of nestlings increased from 11 days up to 20 days after hatching. After then, nestlings reduced begging and fledged a nest 24 days after hatching. This study provided information of breeding ecology to protect and manage population of Black woodpeckers which are endangered species in South Korea.

조현병 환자에서 정신병리와 인지 기능과의 연관성

김성진(Sung-Jin Kim),심주철(Joo-Cheol Shim),공보금(Bo-Geum Kong),강제욱(Je-Wook Kang),문정준(Jung-Joon Moon),임지섭(Ji-Seop Lim),김임규(Im-Gyu Kim),김연수(Yeon-Sue Kim),오민경(Min-Kyung Oh),정도운(Do-Un Jung) 대한생물치료정신의학회 2013 생물치료정신의학 Vol.19 No.2

Objectives:Cognitive dysfunction is one of the major symptoms of schizophrenia, and has a diverse effect on the prognosis and course of schizophrenia. Several studies have been done about the correlation between cognitive dysfunction and clinical symptoms of schizophrenia, but the results of those studies were not clear. This study was performed to confirm the correlation between cognitive dysfunction and clinical symptoms of schizophrenia. Methods:We studied 117 patients with schizophrenia. We assessed clinical symptoms and the cognitive function of the patients, and analyzed the statistical correlation between clinical symptoms and the cognitive function. For clinical symptoms, Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression-Severity(CGI-S) and Hamilton Depression Rating Scale(HDRS) were performed. For cognitive function, Digit Span Test, Visual Span Test, Stroop Color Word Test(SCWT), Continuous Performance Test(CPT), Wisconsin Card Sorting Test(WCST), and Digit Symbol Substitution Test(DSST) were performed. Results:There was significant correlation between CPT and clinical symptoms. The WCST revealed that Categories Achieved(CA) have significant correlation with disorganization symptoms among 5-factor model of PANSS (p<0.05). DSST revealed that the total score(p<0.01), negative syndrome(p<0.01), general psychopathology(p<0.01) among 3 kind major area classification of PANSS and disorganization symptoms of 5-factor model of PANSS(p<0.001) have significant correlation. Conclusion:This study revealed the correlation between the cognitive function and a part of clinical symptoms in patients with schizophrenia, as shown through the CPT, WCST and DSST.

청색광차단 인공수정체와 자외선차단 인공수정체의 시기능 비교

이근영(Geun Young Lee),김임규(Im Gyu Kim),유성(Sung Yu),이광자(Gwang Ja Lee),이규원(Kyoo Won Lee),박영정(Young Jeung Park) 대한안과학회 2017 대한안과학회지 Vol.58 No.1

목적: 백내장 수술을 받은 동일 환자에서 청색광 차단 황색 착색 인공수정체(Acrysof IQⓇ SN60WF)와 자외선 차단 투명 인공수정체(enVistaTM MX60)를 삽입 후 단기간 시력 및 시기능 결과를 비교하고자 한다. 대상과 방법: 양안 백내장 수술을 진행한 44명 환자를 대상으로 한 눈에는 SN60WF를 다른 눈에는 MX60을 삽입하였다. 대상환자는술 전, 술 후 1, 3개월에 굴절력, 나안시력을 측정하였다. 수술 후 3개월째 교정시력, OQAS ⅡⓇ를 이용한 시력의 질 측정, CGT 2000Ⓡ을 통한 대비감도 검사, 자동시야검사를 하여 두 눈에서 시력과 시기능을 비교하였고 두 눈에서 주관적 밝기를 평가하였다. 또한 인공수정체의 반짝임 변성 정도, 인공수정체의 낭내 안정성과 후낭혼탁을 검사하였다. 결과: 술 후 두 군에서 모두 1개월, 3개월째 평균 굴절력과 나안시력, 교정시력은 차이가 없었다(p>0.05). 술 후 3개월째 OQAS ⅡⓇ를 이용한 시력의 질, CGT 2000Ⓡ을 이용한 glare on 또는 off 상태의 대비감도, 시야검사결과 비교는 두 군에서 차이가 없었으며(p>0.05), 두 군 모두 반짝임 변성이 없었고, 후낭혼탁이 발생하지 않았다. 밝기를 묻는 설문에서는 48.3%에서 MX60군이 더 밝게보인다고 답하였다. 결론: 청색광 차단 황색 착색 인공수정체와 자외선 차단 투명 인공수정체는 단기간의 시력과 시기능에 차이가 없었으나 주관적 밝기는 자외선 차단 투명 인공수정체에서 높았다. Purpose: To compare the clinical results of short-term visual acuity and quality of vision after implantation of a yellow-tinted blue light-filtering intraocular lens (IOL) (Acrysof IQ?? SN60WF) and an clear ultraviolet (UV) light filtering IOL (enVistaTM MX60) in the same patient. Methods: 44 patients with bilateral cataract received an SN60WF in one eye and an MX60 in the other eye. All eyes were evaluated for refraction power and uncorrected visual acuity (UCVA) at preoperative and 1, 3 months postoperatively. At postoperative 3 months, corrected visual acuity, quality of vision (OQASⅡ??), contrast sensitivity (CGT 2000??) and visual field(Humphrey Field Analyzer??), and subjective patients response to the degree of brightness were evaluated. Furthermore, glistening degree, intraocular stability, and posterior capsular opacification were examined. Results: There were no significant differences in average refractive power or UCVA at 1 and 3 months (p > 0.05) between the two groups. At 3 months after cataract surgery, the quality of vision according to OQASⅡ??, the contrast sensitivity according to CGT 2000?? with the glare either on or off, and visual field; showed no difference between the two groups (p > 0.05). Both IOLs had no glistening and posterior capsular opacity. The patients response to the degree of brightness shows that MX60 (48.3%) has a higher degree of satisfaction. Conclusions: Yellow-tinted blue light-filtering IOL and clear UV light-filtering IOL had no difference in short-term visual acuity and quality of vision. Subjective brightness perception, however, was better with clear UV light-filtering IOL.