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      • KCI등재
      • 신체형 장애 환자에서 동반되는 인격 장애/성향의 유형 및 빈도에 대한 연구

        김원식,이철,김창윤,한오수,Kim, Won-Sik,Lee, Chul,Kim, Chang-Yoon,Han, Oh-Su 한국정신신체의학회 1997 정신신체의학 Vol.5 No.1

        This study was conducted to identify the relationships between personality disorders/traits and somatoform disorders. After the patients were screened through self-rated SCID-II Questionnaire(Structured Clinical Interview for DSM-III-R, Questionnaire), the researcher got psychiatric history, performed clinician-rated SCID-P(Structured Clinical Interview for DSM-III-R, Patient Edition), classified and diagnosed mental disorders with SCID-P, and evaluated SCID-II(Structured Clinical Interview for DSM-III-R, Personality Disorders) by direct interview. The prevalencies of avoidant, obsessive-compulsive, schizotypal, narcissistic, paranoid, dependent, self-defeating, borderline personality disorders/traits in patients with somatoform disorders were diagnosed as 67.4%, 48.8%, 44.2%, 41.9%, 37.2%, 34.9%, 34.9%, 32.6%, respectively. The frequencies of self-defeating and schizotypal PD/traits were significantly higher than those of other neurotic control group. The results of this study could be regarded as replicating the results of previous studies that had reported most of all patients with somatoform disorder had presented with personality disorders/traits. This study, however, showed that the patients with somatoform disorders accompanied not with any specific types of personality disorders/traits but with various types of personality disorders/traits, which was much different from the previous usual clinical impressions. Thus, it is necessary for clinicians to approach the patients with somatoform disorders through more flexible and more supportive methods and attitude, in order that they should treat them more effectively.

      • KCI등재

        천연 소재 복합물이 항아토피 피부염 및 피부재생에 미치는 영향

        김원식,심부용,김동희,Kim, Won-Sik,Sim, Boo-Yong,Kim, Dong-Hee 대한본초학회 2017 大韓本草學會誌 Vol.32 No.6

        Objectives : This study aims to evaluate the effects of natural herb mixutre (NHM) on atopic dermatitis and skin regeneration using in vivo test. Methods : NHM was prepared with DW. 25% of NHM was applied to skin lesion, where atopic dermatitis was induced by DNCB in NC/Nga mice. The levels of cytokines (IL-4, IL-5, IL-6, IL-13, TNF-a, and $IFN-{\gamma}$), and IgE in serum were measured by Luminex. Immune cells (WBC, eosinophil, lymphocyte, and monocyte) in blood were counted by coulter counter. The gross investigation of atopic dermatitis index score test were performed during the NHM treatment period. Also, the histopathological change of dorsal skin was observed by H&E and M&T staining. Results : NHM showed the levels of IL-4, IL-5, IL-6, IL-13, IgE, WBC, eosinophil, lymphocyte, and monocyte in serum or blood were significantly decreased. On the contrary, the productions of FGF, and VEGF were increased in the serum. Also, atopic dermatitis index score in NHM-treated mice were observed in the similar levels to those of normal group. Histological examination demonstrated that NHM suppressed immune cell infiltration and thickening of epidermis, meanwhile the extraction induced collagen production in the dorsal skin. Conclusion : This study demonstrated that NHM is appeared to be effective on atopic dermatitis and skin regeneration efficacy based on the observations with hematologic, gross, and histologic examinations. Therefore, we suggest that NHM could be effectively used as an external therapeutics against atopic dermatitis and a consequence skin damage.

      • KCI등재후보

        성구어의 대비연구 - 독일어와 한국어 성구어의 공통성과 상이성을 중심으로 -

        김원식,Kim Won-Sik 한국독어학회 2004 독어학 Vol.9 No.-

        In der vorliegenden Arbeit wird versucht, sowohl die Gemeinsamkeiten bzw. $\"{A}hnlichkeiten$ als auch Verschiedenheiten der deutschen und koreanischen Phrasologismen festzustellen, wobei die interkultuellen Unterschiede der beiden Sprachgemeinschaften besonders $ber\"{u}cksichtigt$ werden sollen. Dabei wird von den deutschen Phraseologismen ausgegengen und es werden die Entspechungen in den koreanischen gesucht. Die $Entsprechungsm\"{o}glickeiten$ lassen sich wie folgl feststellen: 1) Gemeinsamkeiten von deutschen und koreanischen Phraseologismen (Auge um Auge, Zahn um Zahn; Augen zudrucken) 2) Entspechung von deutschen Phrasologismen und koreanischen Einzellexemen (Grund und Boden; Knall und Fall) 3) Interpretation deutscher Phraseologismen in koreanische Sprache (in Fleisch un Blut $\"{u}bergehen$; eine $H\"{a}nde$ $w\"{a}scht$ die andere) $\"{A}hnlichkeiten$ bzw. Gemeinsamkeiten bestehen vor allem in den Phraseologismen, deren gemeinsame Quelle auf die $\"{U}bernahme$ desselben Kulturgut wie die Antike, die Bibel und die Weltliteratur $zur\"{u}ckzuf\"{u}hren$ ist. Die $\"{A}hnlichkeiten$ zeigen sich auch bei den vielen somatischen Phraseologismen der beiden Sprachen, da manche somatischen Bezeichnungen die gleichen Symbolwerte haben. Hingegen beruhen Verschiedenheiten vorwiegend auf den interkulturellen Unterschieden der beiden Sprachgemeinschaften, die sich historisch­gesellschaftlich unterschiedlich entwickeln und keine Gemeinsamkeiten in Sitten und $Volksbr\"{a}uchen$ haben. Insbesonders bei den phraseologischen Vergleichen kommen viele Tierbezeichnungen als Einheit der Phraseologismen vor, die sich einander stark unterscheiden (dt. arbeiten wie ein Pferd $\to$ kr. arbeiten wie ein Rind; dt. wie Hund und Katze leben $\to$ kr. wie Hund und Affe leben). Die Zwillingsformeln der deutschen Phraseolgismen sind im Koreanischen als Einzellexem oder durch die Redupulikation $auszudr\"{u}cken$(Haus und Hof; klipp und klar; mit $H\"{a}ngen$ und $W\"{u}rgen$). Einige Redewendungen und $Sprichw\"{o}rter$ im Deutschen entsprechen den aus 4-Buchstaben bestehenden Redewendungen im Koreanischen, die aus der chinesischen Kultur stammen(viele Hunde sind des Hasen rod; Gelegenheit macht Diebe). Es sind naturlich manche Redewendungen bzw. $Sprichw\"{o}rter$, deren unterschiedliche Ausdrucksweisen auf die interkulturellen Verschiedenheiten $zur\"{u}ckzuf\"{u}hren$ sind (die $W\"{a}nde$ haben Ohren; der Apfel $f\"{a}llt$ nicht weit vom Stamm)

      • KCI등재

        독일어 성구어를 기저로 한 파생장 - 동사 성구어률 중심으로

        김원식 ( Won Sik Kim ) 한국외국어대학교 언어연구소 2008 언어와 언어학 Vol.0 No.42

        The aim of this paper is an analysis of derivation of Phraseolexem(phrasal lexeme) in German. First, the classes of derived words are discussed. The majority of derived words are nouns. Second, depending on their semantical categories, derived nouns can be classified in the following three types: 1. nomina agentis 2. nomia instrumenti 3. nomina actionis. Finally, Among them, the third type is divided into smaller groups depending on their structures of phrasal lexeme. There is a tendency that many of the derived nouns belong to the field of the social science, especially the legal terms. The word-formation rules are also examined and established, which can be applied to all the noun types discussed above.

      • KCI등재후보

        흰쥐에서 황체발달과 큰포식세포와의 관계에 관한 면역조직화학적 연구

        김원식(Won-Sik Kim),김수일(Soo-Il Kim),손성경(Sung-Kyong Son),양윤석(Yun-Seok Yang),조근자(Geun-Ja Cho) 대한해부학회 2007 Anatomy & Cell Biology Vol.40 No.3

        황체는 프로게스테론을 생산하여 난포발달의 마지막 단계와 배란을 억제함으로써, 발정주기의 생리적 기간을 결정하고, 성공적인 임신을 달성하는데 결정적으로 기여한다. 큰포식세포는 자신이 분비하는 TNF-α를 통해 황체 발달시기에는 황체발달을 자극하고 용해시기에는 용해를 개시, 촉진시키는 작용을 하는 것으로 알려져 있다. 그러나 아직 임신황체와 비임신황체의 발달과 유지에 대한 TNF-α의 작용기전은 확실히 알려져 있지 않다. 흰쥐를 실험동물로 비임신황체와 임신황체에서 TUNEL, 큰포식세포 및 그것으로부터 분비되는 TNF-α에 대한 면역조직화학을 실시한 본 실험의 결과, 비임신황체에서는 큰포식세포가 주로 세포자멸사 소체의 탐식에 관여하지만 임신황체에서는 황체의 유지과정에 주로 관여하는 것으로 나타났다. Within the corpus luteum, macrophages exert luteotropic and luteolytic actions through secretion of TNF-α. However, the mechanisms of luteotropic actions on the development and maintenance of pregnant and nonpregnant corpora lutea are thoroughly unknown.In this experiment, TUNEL, macrophage, and TNF-α immunohistochemistry on the corpora lutea of pregnant and nonpregnant rats (Sprague-Dawley strain) were carried out to reveal the role of macrophages in the developing corpora lutea. The results were as follows; 1) In the nonpregnant corpora lutea, the number of macrophages was increased significantly, and the degree of ED1-immunoreactivity of macrophages was increased moderately. But lutein cells showed low-degree TNF-α-immunoreactivity. 2) In the pregnant corpora lutea, the number of macrophages was decreased significantly, and the degree of ED1- immunoreactivity of macrophages was low. But lutein cells showed moderate-degree TNF-α-immunoreactivity. Based on the above results, it was considered that macrophages in the nonpregnant corpora lutea exert phagocytic action mainly, and the macrophages in the pregnant corpora lutea exert TNF-α-secreting action to maintain the structure and function of lutein cells.

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