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김대겸 한국수산경영학회 1987 수산경영론집 Vol.18 No.1
연어의 美國 養育은 過去 5年동안 평균 300,000톤으로 비교적 안정적이었다. 反面에 동 기간동안 美國의 연어 輸入은 1,800,000파운드에서 19,000,000파운드로 10배나 增加하여 왔다. 이러한 연어의 供給은 70%가 노르웨이에서 이루어졌다. 美國은 1981년까지는 노르웨이로부터 미미한 程度의 연어를 輸入하였지만, 1983年에는 1,768톤, 1984年에는 3,869톤 그리고 1985年에는 6,272톤을 輸入하였다. 카나다産 연어의 輸入價格은 過去 5年前에 $2.58/1b에서 1985年에는 $1.25/1b로 持續的으로 下落하여 왔으나, 反面 노르웨이産 연어의 輸入價格은 同一 期間동안 $3.28/1b에서 $3.45/1b까지 큰 變動없이 維持되어 왔다. 이와 같은 노르웨이産 연어는 1985年에 約 $3.35/1b로 카나다産 연어輸入價格의 約 3배에 달하는 것이다. 美國의 연어의 外形上 消費量은 1881年에 50,000톤이었으나 1985年에는 86%나 증가한 92,000톤으로 급격한 增加現象을 보이고 있다. 特히 每年의 1人當 消費는 1981年에 0.47파운드로부터 1985年에는 0.85파운드로 持續的으로 增加하고 있다. 以上과 같은 狀況을 基礎로 未來의 연어市場價格을 豫測하기 위하여 需要모델을 推定하였다. 推定된 需要모델에 의하면 美國市場에서의 每年의 연어 都賣價格은 供給의 增加에 의해서는 하락하지만 美國의 GNP增加에 의해서는 上昇할 것이라는 점을 나타내고 있다. 本 硏究에 의한 結果는 美國의 總供給量이 25% 增加할지라도 美國의 GNP가 每年 $200,000,000,000씩 增加할 때는 1990年의 연어 都賣價格은 1985年 水準으로 維持될 것이라는 點이다.


수 종의 생약제제가 MC3T3-E1 세포의 염기성 인산분해효소 합성에 미치는 영향
김대겸,김탁,피성희,김현아,최광수,유형근,신형식,Kim, Dae-Kyum,Kim, Tak,Pi, Sung-Hee,Kim, Hyun-A,Choi, Kwang-Soo,You, Hyung-Keun,Shin, Hyung-Shik 대한치주과학회 1999 Journal of Periodontal & Implant Science Vol.29 No.4
Several growth factors and polypeptidesare not commonly yet used for regenerators of bone tissue or alveolar bone because of the insufficiency of studies on their side effects, genetic engineering for mass production and stability for clinical application. Recently, many natural medicines, which have advantage of less side effects and possibility of long-term use, have been studied for their capacity and effects of anti-bacterial, anti-inflammatory and regenerative potential of periodontal tissues. Olibanum, Myrrha, Phlomis Radix, and Cimicifugae Rhizoma have been traditionally used as a drug for treatment of bone disease in oriental medicine. The objective of this study was to examine the ability of alkaline phosphatase(ALP) synthesis of rat calvarial osteoblast(MC3T3-E1) when several natural medicines were supplemented. MC3T3-E1 cells were cultured with ${\alpha}$-MEM(negative control), dexamethasone(positive control), and each natural medicines for 3 and 5 days. And then ALP synthesis was measured by spectrophotometer for enzyme activity and by naphthol AS-BI staining for morphometry. All of the natural medicines induced higher activity of ALP synthesis than the negative controls. Especially Olibanumind uced the higher activity than the positive controls (p<0.05). In the aspects of culturing time, except Cimicifugae Rhizoma, the natural medicines induced higher activity of ALP synthesis at 5 days than at 3 days (p<0.05). In morphometry, all of the natural medicines showed statistical significance compared to the negative control (p<0.05). Myrrha a n d Phlomis Radix showed larger positively stained area at 5days than at 3 days, whereas the others did not showed the difference between at 5 and at 3 days(p<0.05). These results indicate that several natural medicines have an inducing ability of ALP synthesis in MC3T3-E1 cells.
상백피(桑白皮)가 제 I형 알레르기 천식(喘息)모델 흰쥐의 BALF내(內) 면역세포(免疫細胞) 및 혈청(血淸) IgE에 미치는 영향(影響)
김대겸,이상재,김광호,Kim Dae-Kyeom,Lee Sang-Jae,Kim Kwang-Ho 대한예방한의학회 2002 대한예방한의학회지 Vol.6 No.1
Background: SBP(桑白皮)is an herbal medicine which has been used in oriental medicine as a traditional therapeutic agent of bronchial asthma. Objective: This study was performed to investigate the effect of SBP on the anti-hypersensitivity and immune response in the murine of type I hypersensitivity induced by the experiment. Materials and Methods: Laboratory rats were primary sensitized with OA(ovalbumin); on day 1, rats of a Control group and Sample group (SBP group) were systemically immunized by subcutaneous injection of 1 mg OA and 300mg of Al(OH)3 in a total volume of 2ml saline. The rats of the sample group were orally administered with an SBP water extract for 14 days after primary immunization. On day 14 after the systemic immunization, rats received local immunization by inhaling 0.9% saline aerosol containing 2%(wt/vol) OA. A day after local immunization, BAL fluid and serum were collected from the rats. Total cell, lymphocyte, CD4+ T cell, CD8+ T cell, CD4+/CD8+ ratio in the BALF, and IgE level in serum were measured and evaluated. Results: SBP showed a suppressive effect on the immune response in the rats. 1. Total cells in the BALF decreased in the SBP treated group in comparision to the control group, but statistic differences were not observed. 2. Total lymphocytes in the BALF were statistically decreased in SBP treated group in comparision to the control group. 3. CD4+ T cells in the BALF were statistically decreased in SBP treated group in comparision to the control group. 4. CD8+ T cells in the BALF were not statistically different in SBP treated group and the control group. 5. The ratio of CD4+/CD8+ in the BALF was statistically decreased in SBP treated group in comparision to the control group. 6. The IgE level in serum decreased in the SBP treated group in comparision to the control group, but statistic differences were not observed.
김대겸 대한의사협회 2023 대한의사협회지 Vol.66 No.1
Background: Recently, it was revealed that Jong-Ha Kim was the first self-employed Korean physician in Daejeon city of South Korea during the Japanese colonial period. However, little is known about him. In this paper, the author aimed to search for historical records of his activities as the first Korean physician in Daejeon city. Current Concepts: Kim’s clinic in Daejeon city was called Chung-Ang Clinic. This is all that has ever been confirmed about Jong-Ha Kim. The author has been searching for his medical record for the last year. Kim’ medical records were collected from journal papers on the modern history of Korea, National Institute of Korean History database, Naver news library archive, official gazette of the Japanese government-general of Korea, database of Seoul National University alumni, and a resume of a professor at the Hamhung Medical School. The results are as follows. He was born in Shinchang-ri Hamheung city Hamgyeongnam-do on August 9, 1900. He graduated from the missionary school established by Canadian missionaries and was admitted to Kyungseong (Keijo) Medical School in 1918. It was recently discovered that he participated in the Independence movement on March 1, 1919. His picture, an old leaflet for his clinic which he had used, and his resume as a professor at the Hamhung Medical School were discovered for the first time. Discussion and Conclusion: The historical records of Jong-Ha Kim’s life provide insight into the lives of contemporary doctors in modern Korea. During the period of 1900 to 1950, which encompasses his historical records, significant events took place in Korean history, and he actively participated in these events. Despite facing numerous difficulties as a doctor in modern Korea, Jong-Ha Kim made decisions that had a great impact. He was a great doctor who served as a good role model.