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Base Sequence의 변화가 이중나선 Oligonucleotides의 열적 안정성과 Dynamics에 미치는 효과
홍석주,유승렬,김은희,권태익,허성호 충남대학교 기초과학연구소 1997 忠南科學硏究誌 Vol.24 No.2
We have synthesized four model oligonucleotides containing biologically significant base sequence and observerd the effects of variation of the base sequence on thermal stability and dynamics of their double helical structures with NMR spectroscopy and UV melting experiments. The results showed that variation of the base sequence could cause no observable change in the global structure of oligonucleotide double helices but cause perturbation of the local structure. This resulted in the change in dynamics of double helices and furthermore in a significant effect on thermal stability. Binding of berenil to each oligonucleotide also had an effect on dynamics and thermal stability of its double helical structure differently upon its base sequence.