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권오율,남창규 世明대학교 한의학연구소 2002 韓醫學硏究所 論文集 Vol.4 No.-
This study was undertaken to define the effect of Oplopanacis Cortex on the phenylephrine-induced arterial contraction and the mechanism of Oplopanacis Cortex-induced relaxation. In order to investigate the effect of Oplopanacis Cortex on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of Oplopanacis Cortex-induced relaxation, Oplopanacis Cortex extract infused into contracted arterial strips induced by phenylephrine after treatment of indomethacin, tetraethylammonium chloride or N_(t) nitro-_L-arginine. The relaxation of Oplopanacis Cortex was dependent on the presence of endothelium, showing that Oplopanacis Cortex-indeced relaxation was not observed in the strips damaged endothelium. The endothelium-dependent relaxation induced by Oplopanacis Cortex was suppressed by the pretreatment of N_(t) nitro-_L-arginine, but it was not observed in the strips pretreated or tetraethylammonium chloride. These result demonstrated that Oplopanacis Cortex may inhibit phenylephrine-induced constraction through the production of nitric oxide in the vascular endothelial cells.
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권오율,남창규,정찬길 世明대학교 한의학연구소 1999 韓醫學硏究所 論文集 Vol.2 No.-
The purpose of this study was to analyze the effect and mechanism of Sophorae Radix on arterial experimental section contracted by PE(phenyl-ephrine). The results were summarized as follows; 1.Sophorae Radix significantly ingibited the PE-induced contraction of artery, accordingly as concentration of Sophorae Radix increased. 2.Sophorae Radix significantly ingibited the PE-induced contraction of artery both with intact endothelium and removed endothelium. 3.The ingibiting effect of Sophorae Radix on contracted strips was not changed by the pretreatment of NLA(Nω-nitro-L-arginine). 4.Sophorae Radix more significantly inhibited the PE-induced contraction of artery than KCI-induced. 5.The mechanism of inhibition of Sophorae Radix on contracted strips is suggested that Ca++ was blocked from the external medium.
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An Assessment of Korea’s Transition to a Knowledge-Based Economy
O. Yul Kwon(권오율) 충남대학교 경영경제연구소 2010 경영경제연구 Vol.33 No.2
지식기반경제(knowledge-based economy)로의 이행이 시급하다는 인식 하에 한국 정부는 2000년에 이를 촉진하기 위한 전략과 프로그램을 수립했다. 본 연구는 지식기반경제의 네 가지 기본 요소(제도, 인적 자원, 정보통신 사회기반시설, 혁신 체제)를 기초로 한국의 지식기반경제로의 이행 정도를 평가하고, 이를 세계적인 선두 그룹 국가들, 그리고 동아시아 신흥국들과 비교하였다. 평가 결과 한국의 지식기반경제로의 이행은 이미 상당한 정도로 진행되어 한국 경제는 곧 선두 그룹 국가들과 비슷한 수준에 이를 것으로 기대된다. 그러나 다른 한편 한국은 이를 장려하기 위한 적절한 제도 및 정책, 지식의 창조와 전파, 과학 기술에서의 혁신 역량의 향상, 그리고 증가하는 정보 격차 문제의 해결 등 다양한 과제에 직면해 있다. 이 과제들은 본질적으로 정치적ㆍ문화적 성격을 띠고 있다. 비효율적인 정치 체계와 문화적 정체라는 문제를 안고 있기 때문에 더욱 심도깊은 개혁을 추진하고 이러한 문제들을 다루기 위해서는 정부와 사회의 긴밀협조가 필요하다. In recognition of the ineluctable transition to a knowledge-based economy (KBE), the Korean government laid out its strategy and programs to promote a KBE in 2000. This paper assesses Korea’s progress of the transition across the four pillars of a KBE (institutions, human resources, ICT infrastructure, and innovation system) and in comparison with a group of world leaders in KBEs and the emerging economies in East Asia. The transition of the Korean economy to a KBE has already progressed substantially, and Korea is well-poised to soon be on par with KBE global leaders. Yet, Korea has faced a variety of challenges such as an establishment of appropriate institutions and policy, creation and diffusion of knowledge, improvement in innovation capacity in science and technology, and dealing with the rising digital divide. These challenges are to a large extent politico-cultural in nature. Burdened with an inefficient political system and cultural inertia, a concerted effort of the government and society is required to undertake further reform and address those identified issues.
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황련해독탕(黃連解毒湯)이 가토(家兎)의 혈관긴장성조절(血管緊張性調節)에 미치는 영향(影響)
남창규,김호현,정찬길,성현제,권오율,Nam Chang-Gyu,Kim Ho-Hyun,Jeong Chan-Gil,Sung Hyun-Jea,Kwon Oh-Yul 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2
Objective : The purpose of this study was to analyze the effects of HwangRyunHaeDok-Tang and combinations of constituent herbs on the arterial contraction. Methods : In order to investigate the effects Scutellariae Radix. Coptidis Rhizoma, Phellodendri Cortex and Gardeniae Fructus, in which one of them, two of them, and all of them, were used to exam. Results : The results were summarized as follows; 1. HwangRyunHaeDok-Tang significantly inhibited the contraction of artery induced by Norepinephrine(NE). However the atonic effect was slightly blunted when the vascular endothelial cell was removed. No significant change in the atonic effect of HwangRyunHaeDok-Tang was found when $_L-NNA$ was used as a preliminary treatment. These results indicate that the vascular atonic effect by HwangRyunHaeDok-Tang is slightly dependent on the endothelial cell, and that the HwangRyunHaeDok-Tang works directly to the vascular smooth muscle in creating the vascular atonic effect. 2. The pretreatment of HwangRyunHaeDok-Tang extract significantly inhibited the contractile response to additive application of $Ca^{2+}$ in the strips which were contracted by NE in $Ca^{2+}$-free solution. 3. HwangRyunHaeDok-Tang extract increased the contraction of arterial smooth muscle induced by KCl. Therefore, it can be concluded that HwangRyunHaeDok-Tang may block the NE-receptor or receptor-operated $Ca^{2+}$ channel. 4. It was determined that Scutellariae Radix, Coptidis Rhizoma and Phellodendri Cortex among the ingredients of HwangRyunHaeDok-Tang have a vascular atonic effect. In addition, those ingredients plays a role in strengthening the atonic effect by working with other herbal medicines. Gardeniae Fructus causes the blood vessel to contract. but it does not influence the atonic effects of other herbal medicines. However Gardeniae Fructus tends to inhibit the vascular atonic effect of Phellodendri Cortex. Conclusion : Based on the above results, it can be said that HwangRyunHaeDok-Tang can be applied to cure hypertension considering those three herbs have significant effects of relaxation.
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