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류마티스 관절염 환자의 활액과 활막조직에서의 IL - 6 의 활성도
조석구(Seok Goo CHo),이상헌(Sang Heon Lee),홍연식(Yeon Sik Hong),조철수(Chul Soo Cho),박석영(Seok Young Park),박동준(Dong Jun Park),김호연(Ho Youn Kim),이정용(Jung Young Lee),김상호(Sang Ho Kim),변광호(Kwang Ho Pyun) 대한내과학회 1993 대한내과학회지 Vol.45 No.2
N/A Background: Interleukin-6 (IL-6), previously known as B cell stimulatory factor 2 (BSF-2) is a multifunctional cytokine that is produced by a various cells and plays an important role in the host defence mechanism such as regulation of immune response, acute phase reaction and hematopoiesis. Recent investigations have demonstrated that unregulated expression of IL-6 gene and overproducion of lL-6 were involved in the pathogenesis of cardiac myxoma, Castleman's disease, autoimmune disease, proliferative glomerulonephritis and certain lymphoid malignancies, especially plasmacytoma/multiple myelomas. We tried to evaluate the regulatory effect of IL 6 an the pathogenesis of rheumatoid arthritis (RA) which is characterized by hyperactivation of 8 cells, presence of various autoantibodies and increase in acute phase proteins and platelets. Methods: The IL-6 activity was measured by bioassay using the murine IL-6 dependent hybridoma cell lines (MH60. BSF2), ELISA method and immunohistochemical analysis. Results: 1) IL-6 activity was significantly elevated m synovial fluid from patients with rheumatoid arthritis (RA, n= 25) as compared with osteoarthrits (OA, n=6) and seronegative arthritis (SNA, n=4) (p<0.05). 2) IL-6 activity was also elevated in serum from patients with RA as compared with other disease (P <0.01). 3) High IL-6 activity and destructive changes in affected joints had a tendency to be correlated (r=0.716), And positive correlations between IL-6 activity and C-reactive proteins in serum were observed in patients with RA (r=0.752). 4) Immunohistachemical analysis demonstrated that positive-staining cells were located on the perivascular space. Conclusion: The results suggest that unregulated production of IL-6 may play an important role in the pathogenesis of RA and could explain local as well as generalized symptoms of RA. However, it is not known whether excessive production of IL-6 is a primary event in the disease process, or secondary consequence.
돼지 적출 심장 관상동맥에 있어서 Perivascular Nerve Stimulation에 의한 Cholinergic 수축 작용
이한기,구봉오,문상은,심철수,Lee, Han-Ki,Goo, Bong-Oh,Moon, Sang-Eun,Shim, Chul-Soo 대한물리치료학회 2001 대한물리치료학회지 Vol.13 No.1
The purpose oi this study is to identify clearly the physiologic significance of autonomic nervous system. This study is to find the loose of endogenous neurotransmitter while using the neural response of the neural excitatory action which is distributed to the perivascular smooth muscle through the electrical stimulation of the smooth muscle of coronary artery of pig. The effects of perivascular nerve stimulation were investigated on isolated coronary artery of pig.1 . The magnitude of contractile response to perivascular nerve stimulation increased with increasing frequency (2-80 Hz) of stimulation. 2. The contractions to perivascular nerve stimulation(40V, 40Hz. 0.5msec, 1 min) were increased greatly by pretreatment of the cholinestrase inhibitor physostigmine. 3. The contraction to perivascular nerve stimulation(40V,40Hz, 0.5msec, 1min) was antagonised markedly by the muscarinic antagonist atropine. 4. The contraction to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1 min) was blocked by the neural blocker tetrodotoxin. 5. The contractions to perivascular nerve stimulation(40V. 40Hz, 0.5msec, 1 min) were not affected significantly by the -adrenergic antagonist phentolamine or - adrenergic antagonist propranolol. 6. The contractile response by the acetylcholine was increased by the pretreatment of cholinestrase inhibitor physostigmine. The finding suggest that it is powerful excitatory action linked to muscarinic receptor by cholinergic nerve in coronary artery of pig.
플라이휠 에너지 저장 시스템을 위한 공심형 고정자 코어를 갖는 Halbach 배열 영구자석 동기전동기의 특성해석
장석명(Seok-Myeong Jang),최지환(Ji-Hwan Choi),김진순(Jin-Soon Kim),한상철(Sang-chul Han),이정필(Jeong-Phil Lee),구철수(Cheol-Soo Goo) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.4
This paper deals with characteristic analysis of Halbach array Magnetized permanent magnet Synchronous Machine with Air-cored stator for flywheel energy storage system (FESS). For deriving characteristics such as flux density, back electromotive force (back-EMF) and torque, electromagnetic field analysis based on space harmonic method is performed. Also, eddy current loss analysis and copper loss calculation are performed.