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Solvent Deposition Method 를 利用한 Indomethacin 製劑의 溶出特性에 관한 硏究
구경문,장은진,한혜성 숙명여자대학교 1984 藥硏 Vol.15 No.-
In order to evaluate the pharmaceutical aspects of solvent deposition method where drug is solvent deposited on the surface of excipients, a study has been made on dissolution characteristics of indomethacin solvent deposited on Avicel^R. In a solvent deposition system, the drug to excipient ratio effect much on dissolution rates of indomethacin. The experimental results are as follows. 1. The solvent deposition system formation was confirmed by scanning electron microscope. 2. Total ammount of indomethacin dissolved from solvent deposition system in pH7.2 at 30 minutes were enhanced about 14 to 24 percentage compared with that of physical mixture. 3. Increased dissolution amount of indomethacin from the solvent deposition system in pH7.2 were observed to be alike in the system where the drug-to-excipients weight ratios were 1:3, 1:10, and 1:5. 4. Dissolution behaviors of commercial products depend on the manufactural condition and dissolution rate of 1:3 SD-IM was greater than other commercial products.