종격동에 발생한 태생암 1례

곽상룡,홍기우,김주현,Gwak, Sang-Ryong,Hong, Gi-U,Kim, Ju-Hyeon 대한흉부심장혈관외과학회 1978 Journal of Chest Surgery (J Chest Surg) Vol.11 No.3

Embryonal carcinoma of the mediastinum is a very uncommon disease. This is a report of an embryonal carcinoma in the mediastinum found in a 25 years old Korean male patient who had been suffering from chest pain and intractable coughing for 6 months. 5 weeks prior to this admission hemoptysis and high fever were followed. Right exploratory thoracotomy was performed under the impression of a mediastinal tumor, but found to be unresectable. Irradiation therapy was tried, but no response was observed. Patient expired on 78th day postoperatively.

기관지성 낭종 3례 보고

곽상룡 대한흉부심장혈관외과학회 1978 Journal of Chest Surgery (J Chest Surg) Vol.11 No.4

Bronchogenic cysts are congenital and uncommon lesions which are derived from primitive forgut and usually found within the lung or mediastinum. The increased use of roentgenograms of the thorax and the widening scope of thoracic surgery, many more cases of bronchogenic cysts are being observed. Three cases of bronchogenic cysts operated in the department of thoracic surgery, C.A.F.G.H., are reported and the related literatures are reviewed.

Kartagener's Syndrome ; 2례 보고 (Kartagener 증후군의 기관지확장증의 와과적 치료)

곽상룡,노준량,Kwack, Sang-Ryong,Rho, Joon-Rhyang 대한흉부심장혈관외과학회 1979 Journal of Chest Surgery (J Chest Surg) Vol.12 No.3

Kartagener`s syndrome is a clinical entity comprising a combination of situs inversus, bronchiectasis, and sinusitis or nasal polyposis. This syndrome is rare and is usually seen in a young age group. The syndrome is punctated by recurrent upper respiratory tract infection and pneumonia. This is a report of Kartagener`s syndrome found in 18 years old male and 21 years old female patients who were received surgical treatment of bronchiectasis. The male patient was performed right transposed lingular segmentectomy and lower lobectomy and female patient was perforated left transposed middle lobectomy and lower lobectomy. Both patients were discharged with good results.

관상동정맥루 치험 3예

곽상룡 대한흉부심장혈관외과학회 1982 Journal of Chest Surgery (J Chest Surg) Vol.15 No.1

Communications of coronary arteries with the cardiac cavities have first time been described by Krause in 1865 in a case of an accessory artery draining into the pulmonary artery and later Cayla in a case of a right coronary artery entering the right ventricle. The initial cases have been found accidentally at autopsies, however In recent years after the Introduction of angiography and coronary arteriography, the malformation Is diagnosed during life and is corrected surgically. These conditions are unusual entitles since the advent of angiography they are being diagnosed with increasing frequency. Three patients who had surgical correction of coronary-cardiac chamber fistula at our hospital are presented. In the first case and second case, coronary arteriovenous fistula was corrected horizontal mattress suture ligation with pladget under the cardiopulmonary bypass and third case was corrected double ligation with cardiopulmonary bypass standby. The postoperative courses were uneventful. They discharged without any fistula related complica-tions.

Mitomycin C가 白鼠의 纖維母細胞에 미치는 細胞毒性에 關한 硏究

곽상룡,유태전,김정중,박승택,정연태 圓光大學校 醫科學硏究所 1992 圓光醫科學 Vol.8 No.1-2

Present study was carried out to investigate the cytotoxicity of mitomycin C in cultured rat fibroblasts. The colorimetric assays of neutral red(NR) and tetrazolium MTT and also the measurement of the rate of DNA synthesis and sister chromatid exchange (SCE) analysis were performed in cells cultured in the media containing various concentrations of mitomycin C. The results are as follows ; 1. The uptake ability of NR was decreased dose-dependently and NR_90 and NR_50 values of mitomycin C were 0.5 μg/㎖ and 2.3 μg/㎖ respectively. 2. Mitomycin C induced the dose-dependent decrease of the activity of mitochondrial succinic dehydrogenase and MTT_90, and MTT_50 values were 0.7 μg/㎖ and 3.4 μg/㎖, respectively. 3. Mitomycin C inhibited DNA synthesis dose-dependently and the rates of DNA synthesis at concentrations of mitomycin C, 0.5 μg/㎖ (NR_90) and 10^-3μg/㎖ were 2 % and 50 % of the control. 4. Frequency of sister chromatid exchange increased dose-dependently. From above results, it suggests that mitomycin C induced the DNA damage at below concentrations which dose not cause cytotoxicity as determined by NR and MTT assays.

흉총창에 의한 심방파열 치험 2례

이두연,곽상룡,Lee, Doo-Yun,Kwack, Sang-Ryong 대한흉부심장혈관외과학회 1980 Journal of Chest Surgery (J Chest Surg) Vol.13 No.1

We have experienced 2 cases of the hunshot wound sof the chest involving cardiac injuries at department of the thoracic surgery, Capital Armed Forces General Hospital during I year from April I 1979 to Jan. 1980. In one case of two patients , he was a 22 years old man who was transported to this emergency room 4 hour 10 minutes after having gunshot wound of the left chest by helicopter. Physical examination showed small inlet in left 3rd ICS and left parasternal border, large outlet in left 8th ICS and left scapular line, no breath sound on left side and distant heart sound. chest roentgenography demonstrated marked pleural effusion in left side and mediastinum shifted to right. As soon as chest X-ray was taken, the bleeding through penetrating wound became profuse and cardiac arrest ensued. Closed chest cardiac massage was started and vigorous transfusion continued, but no effective cardiac activity could not be obtained. The patient was pronounced dead due to exsanguinating hemorrhage from wuwpected cardiac wounds. In this critically injured patient with evidence of intrathoracic hemorrhage and suspected cardiac penetration, only emergency thoracic exploration and immediate surgical control of bleeding points might offer the maximum possibility of survival. The other case was a 23 years old man who was transferred to the emergency room 4 hours 50 minutes after having kmultiple communicated fractures of sternum and linear fracture of right mandible by a missile. Examination revealed about 30% skin loss of the anterior chest wall, weak pulse of 96 beats/min., distant heart sound and decreased breath sounds bilaterally. finding on the chest X-ray films showed multiple sternal fractures, marked pericardial effusion indicating hemopericardium. So, the patient was moved immediately to the operation room where, after endotracheal tube inserted, a median sternotomy was performced. A hemorrhagic congestion of the right upper lobe and marked bulging pericardium were disclosed. The pericardium was opened anterior to right phrenic nerve and exsanguinating hemorrhage ensued from the 0.5cm lacerated wound in the auricle of right atrium. The rupture site of right atrium was occluded with non-crushing vascular clamps and then was over sewn with interrupted sutures. It was thought to be highly possible that he was alive long enough to have cardiorrhaphy because of cardiac tamponade, which prevented exsanguinating hemorrhage. He was taken closed reduction for linear fracture of right mandible 2 weeks after repair of ruptured right auricle in dental clinic. This patient's post-operative course was not eventful.

Adriamycin 이 생쥐 섬유모세포에 미치는 세포 독성에 관한 연구

박종학,곽상룡,김재민,김정중,정연태 圓光大學校 醫科學硏究所 1989 圓光醫科學 Vol.5 No.1-2

Present study was carried out to investigate the cytotoxicity of adriamycin, an anticancer drug on cultured mouse fibroblasts in media containing adriamycin at NR-50 and MTT-50 values. The colorimetric assays of neutral red (NR) and tetrazolium MTT, in addition for the studies of micronuclei and sister chromatid exchange (SCE) were performed on the fibroblasts cultured in the media containing adriamycin. NR-50 and MTT-50 values of adriamycin were 1.2 μg/㎖ and 0.8 μg/㎖ respectively, which were estimated to be severely cytotoxic to the cell. The frequencies of micronuclei and SCEs in the adriamycin treated cells were very high at NR-50 and MTT-50 values. These results indicate that adriamycin have highly mutagenic and severe cytotoxicity on cultured mouse fibroblasts.