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폐경기증상 치료에서 승마추출물과 호르몬보충요법의 비교연구
이병익(Byoung Ick Lee),고승권(Seung Kwon Koh),황성욱(Seong Ook Hwang),박지현(Jee Hyun Park),김종화(Chong Wha Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.8
목적 : 폐경 증상에 대한 장기간의 호르몬 보충 요법은 유방암에 대한 공포와 부작용으로 말미암아 새로운 대체요법에 대한 관심이 절실히 요구되는 실정이다. 이에 본 연구는 승마추출물이 폐경 여성에 있어서 폐경 증상을 완화시키는데 호르몬 보충 요법의 대체요법으로 사용될 수 있는 지 알아보고자 시행하였다. 연구 방법 : 폐경 증상을 호소하는 폐경 여성 74명을 위약군 (Placebo: 12명), 승마추출물군 (Feramin: 32명), 호르몬보충요법군 (Premarin: 30명)으로 나누어 3개월간 약물을 투여하였다. 총 3회 (약물 투여전, 투여 1개월, 투여 3개월)에 걸쳐 폐경 증상의 변화는 Kupperman index의 변화로, 골대사의 변화는 Osteocalcin과 Deoxrpyridinoline을 측정하여, 지질대사의 변화는 총 콜레스테롤, 중성지방 및 고밀도 콜레스테롤을 측정하여 계량화 하였다. 약물투여에 대한 부작용은 투여 3개월 후 조사하였다. 결과 : 위약군과 비교하여 승마추출물은 Kupperman index를 낮추는데 있어서 호르몬 보충 요법만큼 효과적이었다 (투여 1개월: p<0.05, 투여 3개월: p<0.01). 골대사 및 지진대사의 변화에 있어서 위약군에 비하여 약간의 긍정적인 효과를 보이나 통계학적으로 유의하지 않았다. 부작용은 호르몬보충요법에 비하여 훨씬 적었다. 결론 : 승마추출물은 폐경 증상을 완화시키기 위한 목적으로 호르몬 보충 요법을 대치할 수 있는 안전하고 효과적인 치료제이며 특히 호르몬 보충 요법의 부작용이나 장기간투여에 따른 유방암에 대한 공포로 말미암아 투여를 거부하는 경우 새로운 대체요법으로 생각된다. Objective : The fears and side effects of a prolonged hormone replacement therapy on the postmenopausal symptoms reinforce a growing interest about alternatives. The present study was performed to investigate whether black cohosh root extract (BCRE) can be used or not as an alternative to hormone replacement therapy (HRT) in order to relieve postmenopausal symptoms. Material & Methods : Randomized, double-blind prospective clinical trial examined the effects of BCRE and HRT on Kuppetman index, biochemical bone markers, lipid profiles, and side effects in 74 women with postmenopausal symptoms. Treatments included placebo (Festal^??) (n=12), BCRE (Feramin^??) (n=32) and HRT (Premarin^??) (n=30) for 3 months. Kupperman index, biochemical bone markers (osteocalcin and deoxypyridinoline), and lipid profiles (total cholesterol, triglyceride and HDL-cholesterol) were measured at 0, I and 3 months. Side effects were checked at 3 months. Results : BCRE was significantly effective in lowering of Kupperman index as much as HRT at two control times (1 month: p<0.05, 3 months: p<0.001). It also showed slightly favorable effects on biochemical bone markers and lipid profiles but not statistically significant. Fewer side effects were seen in BCRE than HRT. Conclusion : BCRE appears to be a safe and effective alternative to HRT for early postmenopausal symptoms and may be especially useful in women with intolerances or contraindications to traditional HRT.
선택적 제왕절개분만에 있어서 마취방법에 따른 태아산혈증의 비교연구
이정헌 ( Jeong Hun Lee ),이호 ( Ho Lee ),고선환 ( Seon Hwan Koh ),정해련 ( Hoe Ryoun Jung ),김상훈 ( Sang Hoon Kim ),이지영 ( Ji Young Lee ),송은섭 ( Eun Seop Song ),고승권 ( Seung Kwon Koh ),임문환 ( Moon Hwan Yim ),이우영 ( Woo 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.4
목적 : 건강한 산모에서 선택적 제왕절개 분만을 시행하였을 때 흡입마취와 경막외마취, 척추마취가 태아산혈증에 일으키는 변화와 Apgar score에 대한 영향을 알아보고자 하였다. 대상 및 연구 방법 : 2001년 3월 1일부터 2002년 8월 31일까지 인하대부속 인하대병원을 방문한 임신 37주 이상의 건강한 산모 98명을 대상으로 하였다. 이들의 태아는 단태아로서 초음파상 태아 체중이 2.5㎏ 이상이었다. 제왕절개 분만의 마취방법은 흡입마취, 경막외 Objective : The purpose of this study is to determine the effects of the methods of anesthesia on fetal acidemia following elective cesarean delivery among uncomplicated healthy parturients at term, with a single fetus and is to see the correlation of tha
최범 ( Beom Choi ),박지현 ( Ji Hyeon Park ),황석욱 ( Seong Wook Hwang ),고승권 ( Seung Kwon Koh ),조숙 ( Sook Cho ),이우영 ( Woo Young Kim ),정재근 ( Jae Keun Jeong ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12
Because preterm delivery is the major cause of perinatal mortality, a useful predictor of preterm delivery could reduce the perinatal mortality. This study was designed to evaluate the mammary stimulation test to predict which patients may develop preterm delivery. Clinical risk assessments are based on maternal characteristics, demographic factors, behavioral and environmental risk factors, and antenatal risk factors. Uterine contraction in response to mammary stimulation test beween 24 and 33 weeks` gestation, were evaluated in 73 gravid patients. Twenty three patients delivered before term and 50 patients delivered at term. Mammary stimulation test was positive in 43.8% of all patients tested. The positive mammary stimulation test in preterm group was 87.0% and in term group it was 24.0%. Mammary stimulation test predicted the preterm delivery statistically significantly in a relationship of the test results to preterm delivery. Patient having high risk factors was 56.2% in total patients. There were more high risk factors in preterm group(87%) than those in term group(42.0%). Also in high risk patients mammary stimulation test predicted the preterm delivery statistically significantly. The interval beyond 4 weeks between the test and delivery was 82.1%, and within 4 weeks was 17.9%. Positive mammary stimulation test delivered within 4 weeks was 28.6%, and negative mammary stimulation test delivered over 4 weeks was 96.8%. The patients with negative mammary stimulation test did not delivered within 4 weeks. If these findings can be validated in additional samples, the mammary stimulation test may be useful as a predictor of preterm delivery in prematurity prevention programs.
복식 자궁적출술 후 질단부로 발생한 난관 탈출증 1 예
박지현(Jee Hyun Park),이정례(Jeong Rye Lee),황성욱(Sung Ook Hwang),고승권(Seung Kwon Koh),임문환(Moon Whan Im),이병익(Byoung Ick Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.2
Prolapse of the fallopian tube into the vaginal vault after hysterectomy is a rare phenomenon and it occurs more frequently after vaginal hysterectomy than abdominal hysterectomy. The exact incidence of tubal prolapse is unknown, because most of cases remain undiagnosed and may resolve before detection. The tubal prolapse may be suspected when granulation tissue or tender friable tissue are detected in vaginal cuff in women complaining lower abdominal pain, dysparenunia, vaginal discharge, or postcoital spotting. The definitive diagnosis of fallopian tube prolapse is made only by histologic confirmation. Reported methods of treatment have included transvaginal excision or transabdominal excision, cautery, and combined vaginal and laparoscopic salpingectomy. We experienced a case of fallopian tube prolapse after abdominal hysterectomy in a 40-year-old woman. We present this case with a brief review of the literature.
이종훈 ( Jong Hun Lee ),최석진 ( Suk Jin Choi ),최선근 ( Sun Keun Choi ),김루시아 ( Lucia Kim ),송은섭 ( Eun Seop Song ),장진호 ( Jin Ho Jang ),박지현 ( Jee Hyun Park ),송윤섭 ( Yun Seob Song ),고승권 ( Seung Kwon Koh ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.12
Retroperitoneal teratomas, which were found occasionally in children but very rarely in adults, occur mainly at the upper pole of left kidney and diagnosed after they grow very enormously. Authors experienced one case of about 20cm-size retroperitoneal te
6 종류의 생식세포와 육종성 변화를 보인 혼합 생식세포종 1 예
방금화(Chin Hua Fang),박성민(Sung Min Park),송경은(Kyung Eun Song),송은섭(Eun Seop Song),임영구(Young Koo Lim),황성욱(Seong Ook Hwang),고승권(Seung Kwon Koh),조숙(Sook Cho),이우영(Woo Young Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1
Malignant germ cell tumors of the ovary are uncommon neoplasms. Although 20-25% of all ovarian tumors are derived from germ cells, only about 3% of germ cell tumors are malignant. Mixed germ cell tumors contain at least two malignant germ cell elements. These lesions should be managed with combination chemotherapy, preferably BEP. Recently we experienced a case of mixed germ cell tumor with 6 components of germ cell and sarcomatous change in a 11 year old girl. Preoperative CA-125, B-hCG, aFP, LDH, a-1-antitrypsin were elevated and the final pathologic report was mixed germ cell tumor composed of endodermal sinus tumor, embryonal carcinoma, mature and immature teratoma, choriocarcinoma, dysgerminoma and sarcomatous change, Postoperative chemotherapy with 6 courses of BEP regimen was performed and all tumor markers became normal after 4 courses of chemotherapy. What we interested in this case was several components of germ cells and sarcomatous change and the sarcomatous change might be derived from the mature cystic teratoma component, so we present this case with a brief review of the literatures here.
질식분만 후 발생한 복강내 혈관손상의 경피적 혈관색전술 성공
이동현 ( Dong Hyeon Lee ),박인해 ( In Hae Park ),전용선 ( Yong Sun Jeon ),이정헌 ( Jeong Hun Lee ),변성수 ( Sung Soo Byun ),박지현 ( Jee Hyun Park ),송은섭 ( Eun Seop Song ),고승권 ( Seung Kwon Koh ),임문환 ( Moon Whan Im ),이병익 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.8
Even though arterial embolization was introduced as a treatment tool for postpartum hemorrhage, it is not performed frequently. As authors applied arterial embolization successfully to the patient who contracted retroperitoneal hematoma after delivery, we