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정성로,Chung, Sung-Ro 대한생식의학회 1992 Clinical and Experimental Reproductive Medicine Vol.19 No.1
During the years 1983 to 1991, cytogenetic analysis was performed on 19 women with Turner syndrome in order to find out the incidence of symptoms and signs according to the classification of chromosome abnormalities. 1. All of them showed short stature and the mean height in 7 adults was $140.71{\pm}5.26cm$. 2. Among the 19 patients with Turner syndrome, 7 (36.8%) had 45, XO karyotype, 7 (36.8%) had 46, Xi (Xq), and remained 5 (26.3%) had mosaicism. 3. Five patients with mosaicism had 45, X/46, XX (2), 45, X/46, Xi (Xq) (2) and 45, X/47, XXX (1), respectively. 4. Patients with 45, XO and 46, Xi (Xq) had amenorrhea, whereas only 33% (1/3) of patients with mosaicism had amenorrhea. Total incidence of amenorrhea was 84.6% (11/13). 5. Abnormal external genitalia was detected in 63.6% of patients. The incidence of abnormality in patients with mosaicism was lower than that of other groups. 6. OMPC and deafness were detected in 3 of 19 patients. 7. Two cases of cardiovascular abnormalities were found in patients with 45, XO. This study suggests that gnenetic counselling according to the classification of chromosomal abnormalities could be needed in patients with Turner syndrome.
임신성 고혈압 및 자궁내 태아발육제한에서의 태아심박동 각 변수들의 상관분석
윤상순 ( Sang Soon Yoon ),김성희 ( Seong Hee Kim ),주명희 ( Myung Hee Joo ),정경미 ( Kyung Mee Chung ),황정혜 ( Jeong Hyae Hwang ),정성로 ( Sung Ro Chung ),문형 ( Hyung Moon ),차경준 ( Kyung Joon Cha ),박영선 ( Young Sun Park 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.1
목적 : 정상 임신 산모군과 고위험 산모군 (임신성 고혈압, 자궁내 발육제한 등)을 산전 태아 상태를 평가하는 한 방법인 비수축검사를 이용하여, 이들을 선형성에 기초한 상관분석을 통하여 비교분석하였다. 태아의 심박음과 그 제변수 상호간 1차적 관계, 즉 선형성을 두 군사이의 비교를 통하여, 태아의 신경계 및 심혈관계 등의 형태적 기능적 발달과 모체적응 등을 간접적으로 분석해 보고자 하였다. 연구 방법 : 1993년 7월부터 1998년 11월까지 수집된 Objective : We aim to analyze each variable of FHR in high risk pregnancies, namely intrauterine growth restriction (IUGR) and pregnancy-induced hypertension (PIH) including chronic hypertensive vascular disease (CHVD), mild and severe preeclampsia to bui
자궁경부무력증의 수술적 치료에서 기존 자궁경부 봉합술과 생체아교를 이용한 변형 질식 자궁경부 봉합술 후의 치료성적 비교
이성훈 ( Sung Hoon Lee ),윤혜진 ( Hae Jin Yoon ),이용욱 ( Yong Uk Lee ),김현희 ( Hyun Hee Kim ),한현주 ( Hyun Ju Han ),박문일 ( Moon Il Park ),황정혜 ( Jeong Hyae Hwang ),문형 ( Hyung Moon ),정성로 ( Sung Ro Chung ) 대한주산의학회 2004 Perinatology Vol.15 No.2
목적 : 질식 자궁경부 봉합술(transvaginal cerclage, 이하 TVC)를 시행한 적이 없는 자궁경부무력증 환자에게 생체아교를 이용한 변형 질식 자궁경부 봉합술(modified transvaginal cerclage, 이하 MTVC)을 시행하여 기존 TVC후의 치료성적과 비교해 보았다. 연구 방법 : 1996년 1월 이후, 한양대학병원 산부인과에서 자궁경부무력증으로 진단받은 임신부중, 그 첫 치료로서 기존 TVC를 시행받은 94명과, 생체아교를 이용한 MTVC를 시행받은 임신부 44명을 대상으로 비교하였다. 결과 : 기존 TVC를 시행받은 군과 MTVC를 시행받은 군의 임상적 특징은 통계학적으로 차이가 없었다. 분만한 임신주수에서는 각각 평균 36.0주와 37.0주이었으며, 평균 체중 2,797 g와 2,828 g으로 통계학적으로 유의한 차이는 없었다. 그러나 수술후 분만까지 임신유지 기간은 각각 19.5주와 21.5주로 통계학적으로 유의한 차이를(p<0.05) 보였다. 또한, 일반적으로 자궁경부무력증 치료의 성공으로 인정되는 임신 34주를 기준으로 보면, TVC에서의 성공률은 74.0% (71/96), 생체아교를 이용한 MTVC의 성공률은 90.9% (40/44)로서 통계학적으로 유의한 차이(X2=4.503, p<0.05)를 나타내었다. 결론:자궁경부무력증을 진단받은 임신부의 첫 수술적 치료로서 기존의 TVC와 비교하여 볼 때 생체아교를 이용한 MTVC의 치료 성공률이 의의있게 높았다. 이렇게 치료성공율이 높았던 것은, 아마도 2번의 TVC band 사이에 주입하는 생체아교가 질로부터의 상행감염을 막아준 결과라고 추정된다. 향후 이를 규명하기 위한 질액 및 양수의 배양검사 연구가 진행되어져야 한다. Objective : The purpose of our study is to compare the outcome of the modified transvaginal cerclage (MTVC) in patients who had not undergone a previous TVC with the outcome of patients treated with the transvagianl cerclage (TVC). Method : Incompetent cervix patients in the Obstetric/Gynecology department of Hanyang University Hospital post January, 1996 were selected as subjects for this study. 94 patients who received the TVC and 44 patients who received the MTVC using fibrin sealant were compared. The success of the operation was determined in the 34th week of pregnancy, and duration of pregnancy. Results : Clinical characteristics of the TVC group and the MTVC group are showing no significant statistical difference between the two groups. The average gestational age of delivery was 36.0 and 37.0 week and the average weight was 2,797 g and 2,828 g respectively, also showing no significant (p=0.06) statistical difference. However, the duration of pregnancy between surgery and birth was 19.5 and 21.5 weeks showing significant (p=0.013) statistical difference, when the success rates of the treatments of incompetent cervix were observed according to the 34th week standard, TVC showed a 74% (71/96) rate of success and MTVC with fibrin sealant showed a 90.9% (40/44) rate of success, showing a significant statistical difference (X2=4.503, p<0.05). Conclusion: The success rate of MTVC using fibrin sealant showed to be significantly higher than the success rate of TVC. The reason for the difference in success rates is suspected to be because the fibrin sealant injected between the two TVC bands blocked the possibility of infection originating in the vagina. In the future, further research should focus on cultures of vaginal and amniotic fluids.
혈소판 활성인자가 백서의 Progesterone 생성에 미치는 영향
조수현,정성로,황윤영,문형,Cho, Soo-Hyun,Chung, Sung-Ro,Hwang, Yeoun-Young,Moon, Hyung 대한생식의학회 1992 Clinical and Experimental Reproductive Medicine Vol.19 No.1
Platelet activating factor(PAF) has been reported to play a significant role in ovulation, establishment and maintnance of early pregnancy. The object of this study was to investigate the influence of PAF on progesterone secretion in rabbit by measurement of pheripheral blood concentration of progesterone. PAF had no effect on progesterone secretion and did not induce decidual reaction in nonovulatory rabbit. But 8th day of hCG induced pesudopregnant rabbit, PAF significantly increase progesterone secretion. Progesterone level was significantly increased at 0.5 and 4 hours after treatment with $10^{-8}$ M PAF on days 2, 4, 6, 8 of gestation as compared than those treated with normal saline. When PAF was injected 2 days after coitus, progesterone levels on days 4, 6, 10, 14 of gestation was significantly increased than those with saline injected group. These results suggest that PAF increase progesterone secretion from the hCG-primed ovary and during pregnancy in rabbit.
박문일,이기헌,정성로,이재억,문형,김두상,Park, Moon-Il,Lee, Ki-Hun,Chung, Sung-Ro,Lee, Jai-Auk,Moon, Hyung,Kim, Doo-Sang 대한생식의학회 1991 Clinical and Experimental Reproductive Medicine Vol.18 No.1
Etiologic classification was performed in 155 patients with recurrent spontaneous abortion history. The incidence was 9.3% among 1658 pregnant women at Hanyang university hospital during the same period. In etiologic classification, 37 cases of on-going patients for diagnostic evaluation were excluded. Of the remained 118 patients, the patients with unknown etiology were 32 cases (27.1%), and 86 cases were classified into each etiologies using appropriate diagnostic modalities. Anatomic causes were the largest etiology, which revealed 46.6% (55 among 118 patients). The next etiology was immunologic cause, which revealed 24.6% (29 patients). Of the 86 patients who have at least one cause, 40.7% (35 among 86) have two or more etiologies. Furthermore, six cases (7%) have 3 combined etiologies. The uterine synechia and/or incompetent internal os of the cervix, namaly anatomic causes, revealed highest combination ratio than other etilogies. The popular abortion technique in Korea, D&C, seems to be main factors for these anatmic causes. The combined causes rather than single cause of recurrent spontaneous abortion were unique situation in Korea especially with anatomic etiologies. From this point of view, we think anatomic etiologies should be rule out first in the evaluation of the patients. For this purpose, we believe hysteroscopy would be helpful as a diagnostic work-up and treatment modality in the management of recurrent spontaneous abortion patients in Korea.
한동익 ( Dong Ik Han ),구인상 ( In Sang Ku ),김성희 ( Seong Hee Kim ),구미경 ( Mi Kyung Koo ),황정혜 ( Jeong Hyae Hwang ),박문일 ( Moon Il Park ),정성로 ( Sung Ro Chung ),차경준 ( Kyung Joon Cha ),박영선 ( Young Sun Park ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12
목적 : 성별 (sex)에 따른 태아의 차이는 고대로부터 현재에 이르기까지 많은 관심의 대상이 되어왔다. 본 연구는 선형 (linear) 및 비선형적인 (non-linear)분석 방법을 이용하여 태아심박동 (FHR)과 신생아 예후와 관련된 제 변수 등을 분석해 봄으로써 성별에 따른 태아의 행동습성의 차이를 알아보고자 시도되었다. 연구 방법 : 분만 전, 30~42주 사이에 nonstress test (NST)를 시행한 정상산모 중 분만후 태아의 성별을 Objective : The differences between two fetal sexes have been a matter of great concern from ancient times to present day. This study was initiated to research the varying fetal behaviors which would differ according to the fetal sex. Methods : With every