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고숙영(Suk Yung Goo),이진환(Jin Hwan Lee),최준식(Jun Shik Choi),범진필(Jin Pil Burm) 大韓藥學會 1991 약학회지 Vol.35 No.5
This study was attempted to investigate the pharmacokinetics of theophylline (4 mg/kg i.v) in the rabbits pretreated with propranolol (1 and 2.5 mg/kg/hr, infusion) for four hours. The plasma concentration and AUC of theophylline were increased in rabbits pretreated with propranolol as compared with those of normal rabbits. The amount of cumulative urinary excretion and renal clearance and total body clearance were decreased in rabbits pretreated with propranolol as compared with those of normal rabbits. The apparent volume of distribution was slightly affected by change of the clearance of theophylline. From the results of this experiment, it is desirable that dosage regimen of theophylline should be adjusted when theophylline combined with propranolol in clinical pharmacy practice.
Biomineralization Mechanism on Collagen for Bone Tissue Applications
홍재윤,고숙영,김태연,배승훈,이슬,양혜윤,조경철,이우걸 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Collagen (COL) is a protein constituting about 30% of total protein content in human body. In addition, COL is a major organic phase of natural bone. Hydroxyapatite (HA) has been widely used as bone substitutes since HA displays chemical structure similar to bone. On the other hand, the bone formation mechanism has not been wellexplored so far although bone is formed via HA mineralization on COL fiber. In this study, we investigated bone mineralization mechanism under the biomimetic environment. COL film was prepared and film surface was used for the mineralization of amorphous apatite. It was attempted to incorporate metallic trace element in the mineralization process. The mineralized COL morphology and chemical state were analyzed using SEM and EDS.
Interaction of Glycosaminoglycan with Calcium Phosphate-Coated Collagen Film
홍재윤,고숙영,김태연,배승훈,이슬,양혜윤,조경철,이우걸 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Glycosaminoglycan (GAGs) is a group of linear polysaccharides and highly interac with water. There are various types of GAGs and participate in varous biological functions in human body, such as lubricant, signal transduction. We speculated that the some of GAGs play a signficant role in bone metabolism and investigated the interaction of GAG with artificially prepared bone simulant. The bone was mimicked by calcium phosphate-coated collagen and allowed to interact with GAG. The interaction was analytically evaluated using an Fourier transform infrared spectroscope and surface hydrophilicity under various GAG concentrations. The effects of the interaction of GAG with bone simulant on cellular activity were evaluated via cell assay, osteoblast proliferation and differentiation in particular.