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MOS interface에서 trapping을 고려한 Capacitance와 Conductance
高光鍊,金相衡,李元澤,趙南賢 건국대학교 1985 論文集 Vol.21 No.1
The trapping of electrons and holes at a semiconductor surface by traps is located in the oxide adjacent to the semiconductor. The trappings are applied to yield the conductance and capacitance of MOS (Metal Oxide Semiconductor) device, and also the frequency and bias dependence of an MOS capacitor. And the flucuations are considered to be generated by interface charge nonuniformities. Interface state parameters are studied here in MOS capacitors over a wide range of energy by conductance and capacitance. The density of interface states are founded to be function of energy.
백서의 과부하 좌심실에서 Myosin Heavy Chain Gene의 발현 양상과 심근의 형태 변화에 미치는 Cyclosporine의 영향
고광련,박종태 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2
Background: In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic response characterized by increased myocardial cell size and activation of fetal cardiac genes. Recently, the calcineurin inhibitor, cyclosporine has been reported to prevent the development of cardiac hypertrophy, however, others reported data which are disagreed to the cyclosporine effect on the prevention of cardiac hypertrophy. Objective and Method: To clarify whether the calcineurin signaling pathway is a critical for overloaded hypertrophy in vivo and to characterize the cyclosporine effect on the development of cardiac hypertrophy, I examined the effects of cyclosporine on the left ventricular overload in the experimental model of clipping of abdominal aorta between the diaphragm and renal artery for three weeks in rats. Results: Left ventricular mass was larger in the group of clipping of abdominal aorta than in the group of cyclosporine injection after clipping of abdominal aorta, however, which had larger ventricular mass rather than control group. It means that cyclosporine suppress hypertrophic growth. Both treated and untreated animals showed increased nuclear polymorphism and euchromatin pattern, and also, ultrastructurally, showed degenerative changes in the cardiac myocytes such as swelling of subsarcolemmal cytoplasm with indistinct sarcoplasmic reticulum and "T" tubules, loosening of myofibril bundles with decreased electron density, and electron dense mitochondria with decreased number, Characteristically, the group of cyclosporine injection after clipping of abdominal aorta showed polymorphic electron dense unswollen giant mitochondria which was not characteristic in other groups. α-MyHC mRNA including non-spliced mRNA of the group of abdonminal aortic clipping was downregulated in the both groups of clipping of abdominal aorta. β-MyHC mRNA was upregulated in the group of clipping of abdominal aorta and downregulated in the group of cyclosporine injection after clipping of abdominal aorta. From the above results, initial response to overload is a degenerative changes of cardiac myocytes and cyclosporine may suppress hypertrophic response and the fetal gene reactivation such as β-MyHC mRNA in this experiment.