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간질환환자의 말초임파구 염색체에서 Fragile Site의 의의
박경란,김수일,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1
To understand chromosomal instability in hepatitis B virus related disease and significance of fragile sites in hepatoma, lymphocytes of peripheral blood from patients of hepatitis, liver cirrhosis and hepatoma were cultured. Fragile sites of chromosomes were counted by chromosome group and the results were as follows. 1. The frequencies of fragile sites were significantly increased in hepatitis, liver cirrhosis and hepatoma compared with control group. 2. The frequency of fragile sites by chromosome group were appeared in chromosome C, A, B and E group in turn on control group, chromosome C, A and B in turn on hepatitis and liver cirrhosis, and chromosome C, B and A in turn on hepatoma respectively. 3. The frequency of fragile sites was significantly increased in liver cirrhosis with HBsAg( + ) in comparison to HBsAg(-) liver cirrhosis. However no differences of frequency were founded in hepatoma by presence of HBsAg. 4. The common specific fragile sites of chromosome were appeared in chromosome 2q13, 5q34, 6p22 and 11q13, It is presumed that chromosomal instability by hepatitis B virus may induce hepatocellular carcinoma, and the common fragile sites found in chromosome 2q13, 5q34, 6p22 and 11q13 would be correlated with sites of oncogenes. However, more study needs to he done in correlation between fragile sites and oncogenes.