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김혜윰,리향,이윤정,서환호,조남근,강대길,이호섭,Kim, Hye-Yoom,Li, Xiang,Lee, Yun-Jeong,Seo, Hwan-Ho,Cho, Nam-Geun,Kang, Dae-Gill,Lee, Ho-Sub 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.2
The vasorelaxant effect of an extract of Lophatherum gracile Brongn (ELB) and its possible action mechanism were ascertained in aortic tissues isolated from rats. ELB relaxed endothelium-intact thoracic aorta in a dose-dependent manner. However, the induced vascular relaxation was abolished by removal in endothelium of the thoracic aorta. Pretreatment of endothelium-intact vascular tissues with $N^G$-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4]-oxadiazole-[4,3-$\alpha$]-quinoxalin-1-one (ODQ) significantly inhibited vascular relaxation induced by ELB. Moreover, ELB significantly increased cGMP production in aortic tissues, which was blocked by pretreatment with L-NAME or ODQ. The vasorelaxant effect of ELB was attenuated by tetraethylammonium (TEA), and glibenclamide. ELB-induced vasorelaxation was not blocked by atropine, propranolol, indomethacin, verapamil, and diltiazem. Taken together, the present study demonstrates that ELB dilates vascular smooth muscle via an endothelium-dependent NO-cGMP signaling pathway, which may be at least in part related with the function of $K^+$ channels.
고지방 식이로 유도된 당뇨병성 죽상경화 마우스 모델에서 밀몽화의 효능 연구
황선미 ( Sun Mi Hwang ),이윤정 ( Yun Jung Lee ),김은주 ( Eun Ju Kim ),김혜윰 ( Hye Yoom Kim ),리향 ( Xiang Li ),최용준 ( Yong Jun Choi ),조남근 ( Nam Geun Cho ),이호섭 ( Ho Sub Lee ),강대길 ( Dae Gill Kang ) 대한본초학회 2009 大韓本草學會誌 Vol.24 No.4
Objectives: This study was designed to investigate the effects of an aqueous extract from Buddleja officinalis Maxim (ABO) on vascular dysfunction in low-density lipoprotein receptor deficient (LDLr KO) mice. Methods: Present study showed that LDLr KO mice were fed a high fat diet consisting of 60 kcal% fat, with or without 200 mg/day/kg ABO of diet, for 14 weeks. Results: High fat diet-LDLr KO mice were treated with ABO were completely normalized by lowering glucose. ABO reduced intima/media thickness in a high fat diet-LDLr KO mice without affecting plasma cholesterol and triglyceride levels. ABO caused endothelium-dependent relaxation in the acetylcholine-precontracted aorta of high fat diet-LDLr KO mice. ABO increased eNOS expression, while decreased cell adhesion molecules expression in high fat diet-LDLr KO mice. Conclusions: In conclusion, chronic treatment with ABO improved hyperglycemia and endothelium-dependent vascular relaxation as well as exhibited anti-inflammatory effect in diabetic atherosclerotic mouse model, independent of effects on plasma lipids.