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임상재,류왕성,유언호 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.3
The catecholamines are key regulators of many physiologic events in human beings. These catecholamine initiate target-cell response by binding to specific recognition sites, the adrenergic receptors. Super-and subsensitivity of the myocardial receptors and their functional status during myocardial failure have important clinical and pharmacological implications. The development of radioligand binding technique using radioactively labeled hormones or drugs, either agonists or antagonists, opened the new era of receptor investagarion. 〔^3H〕 Dihydroalprenolol was used to identify the veta-adrenergic receptors of rat cardiac membranes in this study. The concentration dependence of 〔^3H〕Dihydroalprenolol binding was studied with labeled compounds of various concentrations ranging from 5x 10^-11 M to 1.5x_-8M. Specific 〔^3H〕Dihydroalprenolol binding was a saturable process and Scatchard analysis of the data showed a single class of binding sites characterized by an equilibrium dissociation constant Kd of 5.2x 10^-9M and a calculated Bmax of about 68.8 fmol/mg protein. The specific binding occurred as rapidly and reversibly as the response to the unlabeled ligand and it increased as a linear function of increasing tissue concentration. Levo epinephrine was more potent than levo norepinephrine in inhibiting 〔^3H〕Dihydroalprenolol binding. The use of 〔^3H〕Dihydroalprenolol to identify beta-adrenergic receptors will make possible the study of alterations in number and affinity of cardiac beta-receptors in many clinical states of altered sensitivity to catecholamines.
빌라조경 설계사례에 관한 연구 : Case Study of Jang-chung Dong Villa
김동찬,이윤수,유재설,박익수,임동민,임상재 경희대학교 부설 디자인연구원 1998 예술· 디자인학연구 Vol.1 No.1
The goal of this study is to propose a plan for the Jang-Chung Dong Villa. This Villa is located on Jang-Chung Dong Jung-Gu, Seoul. And, this place is where high-class residential area. This Site area covers about 1925.6m². This base idea of this plan is to provide a community of dwelling houses with identity and amenity in outdoor spaces in order to create the high-class environment of outdoor spaces. Design principles are established as follow; to make spaces for flexibility in the garden related activities, to provide many chances to contact with nature, and to feel pride in the villa life.
대학캠퍼스내 스타디움 주변지역의 조경계획에 관한 연구 : 경희대학교 수원캠퍼스를 중심으로
김동찬,김선영,성현지,박익수,임동민,임상재 경희대학교 부설 디자인연구원 1998 예술· 디자인학연구 Vol.1 No.1
Today, Suwon campus face circulation and open space problem, especially the spaces in front of Gooksugun, Stadium, and Multimedia Center. In order to solve this problem, therefore we need a rational and organic landscape planning. This plan aims to offer an open spaces which is for comfortable activities as well as better campus landscape. This open space will provide a systematic relationship between individual outdoor space.