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- 저자 : ( Zhenhua Tang ) (검색결과 5 건)
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Wake effects of an upstream bridge on aerodynamic characteristics of a downstream bridge
Zhenhua Chen,Zhenyun Lin,Haojun Tang,Yongle Li,Bin Wang 한국풍공학회 2019 Wind and Structures, An International Journal (WAS Vol.29 No.6
To study the wake influence of an upstream bridge on the wind-resistance performance of a downstream bridge, two adjacent long-span cable-stayed bridges are taken as examples. Based on wind tunnel tests, the static aerodynamic coefficients and the dynamic response of the downstream bridge are measured in the wake of the upstream one. Considering different horizontal and vertical distances, the flutter derivatives of the downstream bridge at different angles of attack are extracted by Computational Fluid Dynamics (CFD) simulations and discussed, and the change in critical flutter state is further studied. The results show that a train passing through the downstream bridge could significantly increase the lift coefficient of the bridge which has the same direction with the gravity of the train, leading to possible vertical deformation and vibration. In the wake of the upstream bridge, the change in lift coefficient of the downstream bridge is reduced, but the dynamic response seems to be strong. The effect of aerodynamic interference on flutter stability is related to the horizontal and vertical distances between the two adjacent bridges as well as the attack angle of incoming flow. At large angles of attack, the aerodynamic condition around the downstream girder which may drive the bridge to torsional flutter instability is weakened by the wake of the upstream bridge, and the critical flutter wind speed increases at this situation.
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Miao Zhang,Zhenhua Yue,Zhijun Liu,Ali Islam,Buriro Rehana,Shu Tang,Jörg Hartung,Endong Bao 대한수의학회 2012 JOURNAL OF VETERINARY SCIENCE Vol.13 No.3
The aim of this study was to assess changes of Hsp70 and HSF-1 protein and mRNA expression in stress-sensitive organs of pigs during transportation for various periods of time. Twenty pigs were randomly divided into four groups (0 h, 1 h, 2 h, and 4 h of transportation). A significant increased activity of AST and CK was observed after 1 h and 2 h of transportation. Histopathological changes in the heart, liver, and stomach indicated that these organs sustained different degrees of injury. Hsp70 protein expression in the heart and liver of transported pigs did not change significantly while it increased significantly (p < 0.05) in the stomach. Hsp70 mRNA levels decreased significantly (p < 0.05) in the heart after 4 h of transportation. However, mRNA expression increased significantly in the liver after 1 (p < 0.05) and 4 h (p < 0.01) of transportation, and increased significantly in the stomach of the transported pigs after 1, 4 (p < 0.01), and 2 h (p < 0.05). HSF-1 levels were reduced at 1 and 4 h (p < 0.05) only in the hearts of transported pigs. These results indicate that Hsp70 mediates distinct stress-related functions in different tissues during transportation.
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( Yanfei He ),( Zhenhua Tang ) 한국정보처리학회 2021 Journal of information processing systems Vol.17 No.3
With the development of mobile edge computing, how to utilize the computing power of edge computing to effectively and efficiently offload data and to compute offloading is of great research value. This paper studies the computation offloading problem of multi-user and multi-server in mobile edge computing. Firstly, in order to minimize system energy consumption, the problem is modeled by considering the joint optimization of the offloading strategy and the wireless and computing resource allocation in a multi-user and multi-server scenario. Additionally, this paper explores the computation offloading scheme to optimize the overall cost. As the centralized optimization method is an NP problem, the game method is used to achieve effective computation offloading in a distributed manner. The decision problem of distributed computation offloading between the mobile equipment is modeled as a multi-user computation offloading game. There is a Nash equilibrium in this game, and it can be achieved by a limited number of iterations. Then, we propose a distributed computation offloading algorithm, which first calculates offloading weights, and then distributedly iterates by the time slot to update the computation offloading decision. Finally, the algorithm is verified by simulation experiments. Simulation results show that our proposed algorithm can achieve the balance by a limited number of iterations. At the same time, the algorithm outperforms several other advanced computation offloading algorithms in terms of the number of users and overall overheads for beneficial decision-making.
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Follistatin N terminus differentially regulates muscle size and fat in vivo
Hui Zheng,Chunping Qiao,Ruhang Tang,Jianbin Li,Karen Bulaklak,Zhenhua Huang,Chunxia Zhao,Yi Dai,Juan Li,Xiao Xiao 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Delivery of follistatin (FST) represents a promising strategy for both muscular dystrophies and diabetes, as FST is a robust antagonist of myostatin and activin, which are critical regulators of skeletal muscle and adipose tissues. FST is a multi-domain protein, and deciphering the function of different domains will facilitate novel designs for FST-based therapy. Our study aims to investigate the role of the N-terminal domain (ND) of FST in regulating muscle and fat mass in vivo. Different FST constructs were created and packaged into the adeno-associated viral vector (AAV). Overexpression of wild-type FST in normal mice greatly increased muscle mass while decreasing fat accumulation, whereas overexpression of an N terminus mutant or N terminusdeleted FST had no effect on muscle mass but moderately decreased fat mass. In contrast, FST-I-I containing the complete N terminus and double domain I without domain II and III had no effect on fat but increased skeletal muscle mass. The effects of different constructs on differentiated C2C12 myotubes were consistent with the in vivo finding. We hypothesized that ND was critical for myostatin blockade, mediating the increase in muscle mass, and was less pivotal for activin binding, which accounts for the decrease in the fat tissue. An in vitro TGF-beta1-responsive reporter assay revealed that FST-I-I and N terminus-mutated or -deleted FST showed differential responses to blockade of activin and myostatin. Our study provided direct in vivo evidence for a role of the ND of FST, shedding light on future potential molecular designs for FST-based gene therapy.
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