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( Ying Ying Han ),전승국 ( Seung Kug Jheon ),김영재 ( Young-jae Kim ) 한국경제통상학회(구 한국경상학회,한국국민경제학회) 2015 경제연구 Vol.33 No.1
본 연구에서 산업별 주가와 거시경제변수사이의 동태적 조건부 상관관계를 도출하였다. 또한 동태적 상관성과 함께 주요거시경제변수(WTI, CPI, IP, IR)들이 어떤 영향을 미치는지를 분석하기 위해 Johansen 공적분 검정과 VECM 모형을 통한 충격반응함수(impulse response function)를 통해 분석하였으며, 공적분 검정을 실시한 결과 내구재산업과 비내구재 산업 모두에서 공적분이 존재하였다. 그리고 충격반응함수 분석 결과 거시경제변수에 대한 영향은 내구재가 비내구재에 비해 상대적으로 크게 나타났다. 그 중에서도 이자율(IR)에 대한 반응은 모든 변수에 대해서 양(+)의 반응을 보이고, 소비자물가지수(CPI)에 대한 반응은 비내구재 산업의 통신(TEL)과 필수소비재(ECG)에서 음(-)의 반응이 나타났으나, 타 산업에 대해서는 완만한 양(+)의 반응이거나 음(-)의 반응에서 양(+)의 반응으로 반전하는 모습을 보여주고 있다. 또한 산업생산지수(IP)는 초기에는 급격한 반응을 보였으나 시간이 지날수록 완만한 양(+)의 값으로 수렴해주는 것을 보여주고 있다. 유가와 이자율이 상승하게 되면 시장에 유동성이 감소하여 주식수익률이 하락할 수 있다는 것을 보여주었다. This paper analyzes the relationships between stock market indexes by industries and macroeconomic variables such as international oil price (WTI), consumer price index (CPI), interest rate (IR) and industrial production (IP) by VECM. The main outcomes based on cointergration test show that there exists cointergration in all variables excluding telecommunication industry in non-durable goods markets, which means that there exist long-run equilibrium relations between the corresponding variables. The results of VECM represent that the variables in durable goods markets are more sensitive than those in non-durable goods markets, and the IR turns out the most influential variable in the VECM outcomes. This result coincides with the fact that sectoral-industrial return can be reduced due to the decreased liquidity in the market if IR increases.
Han Ying-Hao,Mao Ying-Ying,Feng Yao-Yuan,Xiang Hong-Yi,Sun Hu-Nan,Jin Mei-Hua,Kwon Taeho 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.3
In this study, we performed RNA sequencing of Prx II +/+ and Prx II −/− dermal mesenchymal stem cells (DMSCs) to identify differentially expressed genes (DEGs). To explore the role of Prx II in DMSCs, we performed Gene Ontology analysis of the DEGs. The results showed that the DEGs were mainly involved in the biological processes of cell migration, intercellular adhesion, and coordination of the regulation of stem cell homing. Through the construction of protein–protein interaction network, four hub genes Cd274 , Ccl5 , Il1b , and Stat1 involved in cell adhesion and cell homing were screened. Quantitative reverse transcription PCR analysis showed that Cd274 , Ccl5 , Il1b , and Stat1 were down regulated in Prx II −/− DMSCs. miRwalk and Starbase databases were further used to screen the upstream molecules miRNA and lncRNA regulating hub gene. Prx II was found to be involved in the regulation of stem cell homing via the Tctn2/miR-351/Stat1/Il1b axis. Thus, we demonstrated that Prx II is a key molecule in the regulation of the homing ability of DMSCs. Our results provide a theoretical foundation for improving the homing ability of DMSCs by targeting Prx II.
Han Ying-Hao,Mao Ying-Ying,Yu Nan-Nan,Jin Mei-Hua,Jin Ying-Hua,Wang Ai-Guo,Zhang Yong-Qing,Shen Gui-Nan,Cui Yu-Dong,Yu Li-Yun,Lee Dong-Seok,Jo Yu-Jin,Sun Hu-Nan,Kwon Jeongwoo,권태호 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) and Prx II knockout DMSCs (n = 3). The purpose of the study was to elucidate the role of Prx II on allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated; p ≤ 0.05) between the PrxII+/+ (WT) and PrxII−/− sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII−/− samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII−/− vs. PrxII+/+ (WT) samples. These findings suggest that Prx II gene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation.
Han Ying-Hao,Chen Dong-Qin,Jin Mei-Hua,Jin Ying-Hua,Li Jing,Shen Gui-Nan,Li Wei-Long,Gong Yi-Xi,Mao Ying-Ying,Xie Dan-Ping,Lee Dong-Seok,Yu Li-Yun,Kim Sun-Uk,김지수,권태호,Cui Yu-Dong,Sun Hu-Nan 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.
MUTYH Association with Esophageal Adenocarcinoma in a Han Chinese Population
Kong, Feng,Han, Xue-Ying,Luan, Yun,Qi, Tong-Gang,Sun, Chao,Wang, Jue,Hou, Hua-Ying,Jiang, Yu-Hua,Zhao, Jing-Jie,Cheng, Guang-Hui Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Adenocarcinoma of esophagus (AE) is a complex disease, affected by a variety of genetic and environmental factors. Much evidence has shown that the MutY glycosylase homologue (MUTYH) plays a key role in the pathogenesis of many cancers. However, there have been no reports on influence on AE in the Han Chinese population. The objective of this study was to investigate this issue. A gene-based association study was conducted using three single nucleotide polymorphisms(SNPs) reported in previous studies. The three SNPs (rs3219463, rs3219472, rs3219489) were genotyped in 207 unrelated AE patients and 249 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results revealed that the genotype distribution of rs3219472 differed between the case and control groups (OR=1.66,95%CI=1.11-2.48, P=0.012), indicating that an association may exist between MUTYH and AE. These findings support a signifcant role for MUTYH in AE pathogenesis in the Han Chinese population.
Efficient iris localisation using a guided filter
Ying Li Han,Tae Hong Min,Rae-Hong Park IET 2015 IET image processing Vol.9 No.5
<P>Biometric information is widely used in user identification systems. Iris is one of the most reliable and accurate biometric information. In an iris recognition system, the iris localisation is one the most important parts because the performance of an iris recognition system is highly dependent on the accuracy of iris localisation. If unreliable iris regions are used in the iris recognition system, the recognition rate may be degraded. Therefore many researchers have studied the iris localisation methods. Especially, localising an iris region from noisy images is one of the hot topics in the iris recognition researches. In this study, the authors are concentrating on the iris localisation, where an efficient iris localisation method for noisy iris images is proposed. The proposed iris localisation method consists of two steps: pupil boundary localisation and iris boundary localisation. To localise a pupil region, an efficient block-based minimum energy detection method is used, in which specular reflection removal is performed as a preprocessing. Iris boundary is localised using a guided filter, the circular Hough transform and an ellipse fitting method. Experimental results with various test image sets show the effectiveness of the proposed method.</P>
Ying-Ying Zhang,In-Shik Han,Shi-Guang Li,Soon-Yen Jung,박기영,신홍식,Ga-Won Lee,왕진석,이희덕,오정우,Prashant Majhi,Raj Jammy 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.3
In this research, the influence of an interlayer dielectric (ILD) capping layer on the thermal stability of Ni germanide was analyzed. The Ni germanide was formed on a Ge-on-Si substrate by using a one-step rapid thermal process (RTP) at 400 ˚C for 30 sec. We found little difference in the X-ray diffraction (XRD) results, but the proposed structure with oxide ILD capping layer showed better thermal immunity than that without one. Adopting an oxide ILD capping layer resulted in a lower sheet resistance, less surface roughness, and less Ni germanide agglomeration and penetration after high temperature post-germanidation annealing at 500 ˚C. Therefore, oxide capping is promising for improving the thermal stability of Ni germanide for nanoscale germanium metal oxide semiconductor field effect transistors (Ge MOSFETs).