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Bioinformatics Analysis Reveals Connection of Squamous Cell Carcinoma and Adenocarcinoma of the Lung
Fan, Wei-Dong,Zhang, Xian-Quan,Guo, Hui-Lin,Zeng, Wei-Wei,Zhang, Ni,Wan, Qian-Qian,Xie, Wen-Yao,Cao, Jin,Xu, Chang-Hua Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Squamous cell carcinoma and adenocarcinoma are the major histological types of non-small cell lung cancer. Because they differ on the basis of histopathological and clinical characteristics and their relationship with smoking, their etiologies may be different; for example, different tumor suppressor genes may be related to the genesis of each type. We used microarray data to construct three regulatory networks to identify potential genes related to lung adenocarcinoma and squamous cell carcinoma and investigated the similarity and specificity of them. In the network, some of the observed transcription factors and target genes had been previously proven to be related to lung adenocarcinoma and squamous cell carcinoma. We also found some new transcription factors and target genes related to SCC. The results demonstrated that regulatory network analysis is useful in connection analysis between lung adenocarcinoma and squamous cell carcinoma.
Fracture toughness improvement of epoxy resins with short carbon fibers
Wei Dong,Fan-Long Jin,박수진,Heng-Chang Liu 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
This study examined the thermal stability and fracture toughness of diglycidylether of bisphenol-A (DGEBA)/short carbon fiber (SCF) composites using several techniques. The thermal stability of the DGEBA/SCF composites was similar to that of neat epoxy resin. The fracture toughness of the composites was significantly improved relative to the neat resin. The SEM micrographs indicated that a relatively rough surface with shear deformation and tortuous cracks was formed, thereby preventing deformation and crack propagation and inducing higher fracture toughness in the DGEBA/SCF composites.
Wei Dong,Miao Zhao,Fan-Long Jin,박수진 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.7
Graphene nanoplatelets (GNPs) employed as conductive fillers were added to an epoxy matrix, diglycidyletherof bisphenol-A (DGEBA), to enhance the electrical conductivity and electromagnetic shielding efficiency ofDGEBA. In addition, we investigated the influence of GNP fraction on the thermal properties, flexural strength, impactstrength, electrical conductivity, electromagnetic shielding efficiency, and morphology of DGEBA/GNP nanocomposites. The electrical properties indicated that the electrical conductivity of DGEBA/GNP nanocomposites consisting ofhigher than 7.5 wt% GNPs was significantly improved compared to that of pristine DGEBA. The electromagneticshielding efficiency of the nanocomposite showed a maximum value of 3.87 dB at 10 wt% GNPs, which is 287% higherthan that of pristine DGEBA. An analysis of the fracture surfaces of the nanocomposites showed a rough morphologywith numerous micro-cracks. In addition, the GNPs in the DGEBA matrix were stacked and formed a continuousconductive path at high GNP contents.
Two New Bibenzyl Glucosides from Dendrobium chrysotoxum
Dong, Fa-Wu,Luo, Huai-Rong,Wan, Qin-Li,Xu, Feng-Qing,Fan, Wei-Wei,Wang, Kai-Jin,Li, Ning,Hu, Jiang-Miao Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.7
Two new bibenzyl glucosides, 3,3',4',5-tetramethoxybibenzyl-4-O-${\beta}$-D-glucopyranoside (1) and 3,4,4',5-tetramethoxybibenzyl-3'-O-${\beta}$-D-glucopyranoside (2), together with five known ones, chrysotobibenzyl (3), erianin (4), chrysotoxine (5), gigantol (6) and tristin (7) were isolated from the stems of Dendrobium chrysotoxum. The structures of those compounds were elucidated by extensive spectroscopic analysis. Moreover, compounds 1-7 were assessed for inhibitory activity of two enzymes-AChE (acetylcholine esterase) and BChE (butyrylcholine esterase).
2019 Novel Coronavirus (COVID-19) Pneumonia: Serial Computed Tomography Findings
Jiangping Wei,Huaxiang Xu,Jingliang Xiong,Qinglin Shen,Bing Fan,Chenglong Ye,Wentao Dong,Fangfang Hu 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.4
From December 2019, Coronavirus disease 2019 (COVID-19) pneumonia (formerly known as the 2019 novel Coronavirus [2019nCoV]) broke out in Wuhan, China. In this study, we present serial CT findings in a 40-year-old female patient with COVID-19 pneumonia who presented with the symptoms of fever, chest tightness, and fatigue. She was diagnosed with COVID-19 infection confirmed by real-time reverse-transcriptase-polymerase chain reaction. CT showed rapidly progressing peripheral consolidations and ground-glass opacities in both lungs. After treatment, the lesions were shown to be almost absorbed leaving the fibrous lesions.
Comparison of Microbial Diversity and Composition in the Jejunum and Colon of Alcohol-Dependent Rats
( Yang Fan ),( Zhao Ya-e ),( Wei Ji-dong ),( Lu Yu-fan ),( Zhang Ying ),( Sun Ya-lun ),( Ma Meng-yu ),( Zhang Rui-ling ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.11
Alcohol dependence is a global public health problem, yet the mechanisms of alcohol dependence are incompletely understood. The traditional view has been that ethanol alters various neurotransmitters and their receptors in the brain and causes the addiction. However, an increasing amount of experimental evidence suggests that gut microbiota also influence brain functions via gut-to-brain interactions, and may therefore induce the development of alcohol use disorders. In this study, a rat model of alcohol dependence and withdrawal was employed, the gut microbiota composition was analyzed by high-throughput 16S rRNA gene sequencing, and the metagenome function was predicted by PICRUSt software. The results suggested that chronic alcohol consumption did not significantly alter the diversity and richness of gut microbiota in the jejunum and colon, but rather markedly changed the microbiota composition structure in the colon. The phyla Bacteroidetes and eight genera including Bacteroidales S24-7, Ruminococcaceae, Parabacteroides, Butyricimonas, et al were drastically increased, however the genus Lactobacillus and gauvreauii in the colon were significantly decreased in the alcohol dependence group compared with the withdrawal and control groups. The microbial functional prediction analysis revealed that the proportions of amino acid metabolism, polyketide sugar unit biosynthesis and peroxisome were significantly increased in the AD group. This study demonstrated that chronic alcohol consumption has a dramatic effect on the microbiota composition structure in the colon but few effects on the jejunum. Inducement of colonic microbiota dysbiosis due to alcohol abuse seems to be a factor of alcohol dependence, which suggests that modulating colonic microbiota composition might be a potentially new target for treating alcohol addiction.
The miR-146a rs2910164 G > C Polymorphism and Susceptibility to Digestive Cancer in Chinese
Wu, Dong,Wang, Fan,Dai, Wei-Qi,He, Lei,Lu, Jie,Xu, Ling,Guo, Chuan-Yong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: Several studies have reported the role of the miR-146a rs2910164 G > C polymorphism as a susceptibility factor for several digestive cancers. However, the results have been controversial. Therefore, we conducted the present meta-analysis to obtain the most reliable estimate of the association. Methods: PubMed, Embase and Web of Science databases were searched. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between miR-146a rs2910164 G > C polymorphism and digestive cancer risk. A total of four eligible studies including 3,447 cases and 5,041 controls based on the search criteria were included. Results: We observed that miR-146a rs2910164 G > C polymorphism was not significantly correlated with digestive cancer risks when all studies were pooled into the meta-analysis. While we found that miR-146a rs2910164 polymorphism was not associated with gastric cancer, it was significantly linked with hepatocellular cancer risk (the homozygote codominant model: OR = 1.40, 95% CI = 1.04-1.87). In the stratified analysis by ethnicity, significant associations were observed in Chinese population for the allele contrast model (OR = 1.25; 95% CI = 1.12-1.38), for the homozygote codominant model (OR = 1.62; 95% CI = 1.28-2.04), and for the recessive model (OR = 1.38; 95% CI = 1.16-1.64). However, studies with Asian groups presented no significant association for all genetic models. Conclusions: This meta-analysis suggests that the miR-146a rs2910164 G > C polymorphism is a low-penetrant risk factor for digestive cancers in Chinese.
Meng, Dong,Sun, Dan,Zhong, Chengmei,Liu, Tao,Fan, Bingbing,Huo, Lijun,Li, Yan,Jiang, Wei,Choi, Hyosung,Kim, Taehyo,Kim, Jin Young,Sun, Yanming,Wang, Zhaohui,Heeger, Alan J. American Chemical Society 2016 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.138 No.1
<P>Non-fullerene acceptors have recently attracted tremendous interest because of their potential as alternatives to fullerene derivatives in bulk heterojunction organic solar cells. However, the power conversion efficiencies (PCEs) have lagged far behind those of the polymer/fullerene system, mainly because of the low fill factor (FF) and photocurrent. Here we report a novel perylene bisimide (PBI) acceptor, SdiPBI-Se, in which selenium atoms were introduced into the perylene core. With a well-established wide-band-gap polymer (PDBT-T1) as the donor, a high efficiency of 8.4% with an unprecedented high FF of 70.2% is achieved for solution-processed non-fullerene organic solar cells. Efficient photon absorption, high and balanced charge carrier mobility, and ultrafast charge generation processes in PDBT-T1:SdiPBI-Se films account for the high photovoltaic performance. Our results suggest that non-fullerene acceptors have enormous potential to rival or even surpass the performance of their fullerene counterparts.</P>
Yinming Fan,Wei Ling,Bichun Huang,Lifu Dong,Chenglong Yu,Hongxia Xi 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.56 No.-
Mn-Ce/CeAPSO-34 was prepared, in which cerium was incorporated in the SAPO-34 framework throughusing a one-step hydrothermal method, while manganese and cerium were supported on the surface bythe Ethanol dispersion method. The conversion of NOx in selective catalytic reaction with NH3(NH3-SCR)over Mn-Ce/CeAPSO-34 catalyst reached nearly 97.7% at 140 C and remained about 100% in thetemperature range of 160–240 C. Besides, the synergistic effects of cerium in the framework and thesurface on the resistance to SO2 and H2O in low-temperature NH3-SCR were investigated. The resultsdemonstrated that a strong synergistic effect existed in Mn-Ce/CeAPSO-34 catalyst, which showedoutstanding SO2 tolerance and H2O resistance. At the same time, the structural properties and possiblemetal-support interaction of the catalysts were characterized by XRD, SEM, H2-TPR, XPS and TG-DSC. According to the characterization results, Ce could inhibit the deposition of NH4HSO4 on the surface ofthe catalysts and preferred to react with SO2, hence protecting the manganese active sites. Meanwhile,the theoretical results of DFT calculations suggested that Ce site supported on the surface neighbored byCe site in the framework was more capable of reacting with SO2.