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[P110] A case of Secretan`s syndrome mimicking cellulitis
( Jinwoong Jung ),( Youngwook Ryoo ),( Byungho Oh ),( Sungae Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Secretan`s syndrome was first described by Henri-Francois Secretan in 1901, characterized by recurring, firm edema on the dorsum of the hand and rarely on the feet. The etiology, pathology, and treatment are not yet clear, but it is known to occur after repeated minor trauma such as contact with a hard object. For treatment, movement should be minimized by splinting or fixing with a plaster cast, and if there is movement disorder due to swelling, occupational therapy is needed. These conservative treatments often improve symptoms within a few weeks, but may require surgical intervention if symptoms persist or are accompanied by movement disorders or pain. We report a case of secretan`s syndrome on the left hand dorsum which is the first report in Korea.
[P400] A case of AIDS-associated kaposi`s sarcoma
( Jinwoong Jung ),( Sungae Kim ),( Byungho Oh ),( Youngwook Ryoo ),( Junil Kwon ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Kaposi`s sarcoma (KS) is a neoplasm originating from vascular endothelial cells and classified as classical KS, endemic African KS, KS associated with immunosuppressive therapy, AIDS-related KS. AIDS-related KS progress rapidly and often involves nose, eyelid, ear and trunk. Involvement of the internal organs is much more common than the classical type, especially it can cause gastrointestinal obstruction or bleeding. Since highly active antiviral therpay(HAART) has become common, the incidence is decreased, but it is still the most common HIV-related neoplasm. A 51-year-old man visited our clinic with asymptomatic hyperpigmented plaques on left nose and lip for several months. He was diagnosed with kaposi`s sarcoma by skin biopsy. On that day, the patient visited the emergency room with mild dyspnea and was diagnosed with AIDS. AIDS was already progressed and he died of sepsis despite two weeks of antiviral therapy. We report a case of AIDS-associated Kaposi sarcoma found before the diagnosis of AIDS.
[FCT 5] Three cases of cytopenia in patients during the azathioprine treatment for bullous disease
( Jinwoong Jung ),( Byungho Oh ),( Youngwook Ryoo ),( Sungae Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Azathioprine is an immunosuppressive drug that has been widely used in dermatology for the treatment of immunobullous diseases. Myelosuppression is the most important side effect that requires close observation of complete blood cell count. The clinical findings of myelosuppression include general weakness, poor oral intake, nausea, dyspnea and pallor. It can occur within several weeks to years after initial azathioprine treatment, so doing weekly full blood count for the first 4 weeks, followed by reduced frequency of monitoring to a minimum of once every 3 months is recommended. If the myelosuppression is not treated properly, it can cause fever, secondary infection, sepsis, even death. Herein, we present these 3 cases that are educational for dermatologists to keep in mind the risk of myelosuppression during azathioprine treatment.
Eun Jung Cho,Myoung Soo Park,Sahng Seop Kim,Gun Kang,Sunga Choi,이유란,장석종,Kwon Ho Lee,이상도,박진봉,전병화 대한약리학회 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.6
Ulmus davidiana var. japonica Rehder (Urticales: Ulmaceae) (UD) is a tree widespread in northeast Asia. It is traditionally used for anticancer and anti-inflammatory therapy. The present study investigated the effect of an ethanol extract of UD on vascular tension and its underlying mechanism in rats. The dried root bark of UD was ground and extracted with 80% ethanol. The prepared UD extract was used in further analysis. The effect of UD on the cell viability, vasoreactivity and hemodynamics were investigated using propidium iodide staining in cultured cells, isometric tension recording and blood pressure analysis, respectively. Low dose of UD (10∼100μg/ml) did not affect endothelial cell viability, but high dose of UD reduced cell viability. UD induced vasorelaxation in the range of 0.1∼10μg/ml with an ED50 value of 2μg/ml. UD-induced vasorelaxation was completely abolished by removal of the endothelium or by pre-treatment with L-NAME, an inhibitor of nitric oxide synthase. UD inhibited calcium influx induced by phenylephrine and high K+ and also completely abolished the effect of L-NAME. Intravenous injection of UD extracts (10∼100 mg/kg) decreased arterial and ventricular pressure in a dose-dependent manner. Moreover, UD extracts reduced the ventricular contractility (+dP/dt) in anesthetized rats. However, UD-induced hypotensive actions were minimized in L-NAME-treated rats. Taken together, out results showed that UD induced vasorelaxation and has antihypertensive properties, which may be due the activation of nitric oxide synthase in endothelium.
실천공동체에 기반을 둔 부모교육 프로그램 운영모델의 개발 및 적용
이성아(Yi, SungA),정효정(Hyojung Jung) 한국가족학회 2016 가족과 문화 Vol.28 No.2
본 연구에서는 실천공동체에 기반을 둔 부모교육 프로그램의 운영모델을 개발하고 적용하여, 그 효과성을 검증하고자 하였다. 이를 위하여 실천공동체에 대한 선행연구를 토대로 부모교육 프로그램 운영모델을 개발하였으며, 전문가 검토를 통하여 타당화하였다. 개발한 교육 프로그램을 총 107명의 어머니를 대상으로 운영하였으며, 프로그램 운영모델의 효과를 확인하기 위하여 양육 스트레스, 부모 효능감, 가족관계 건강에 대한 사전-사후 검증, 교육 프로그램에 대한 참가자들의 인식을 분석하였다. 실천공동체 기반 부모교육 프로그램 운영모델은 첫째, 참가자들의 양육 스트레스를 낮추고, 부모 효능감과 가족관계 건강을 증진시키는 데에 긍정적인 영향을 주는 것으로 나타났다. 둘째, 본 프로그램 운영모델은 참가자들이 자기 탐색의 기회, 관점 전환의 기회를 마련해줌으로써 근본적으로 양육 문제, 관계 문제를 개선해나가는 데 기여한 것으로 나타났다. The purpose of this study is to develop a model of parent education program based Community of Practice(CoP) and to analyze of outcome of the model. Through the preceding research, the model was developed and verified by expert-opinion data. The parent education model were implemented to 107 participants. The effects of the developed program were analyzed using experimental studies of pre-post test. The program shows significant difference in Parenting Stress, Parent efficacy, Family Strengths. The model showed that improve parenting problems, relationship problems by providing the opportunity of self-exploration, and the chance of switching the perspective on the family