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( Bae Hwan Kim ),( Woo Chan Son ),( Cha Ok Yim ),( Sung Keun Kang ),( Jeong Chan Ra ),( Young Chul Kim ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.5
The potential anti-wrinkle effects of adipose tissue-derived mesenchymal stem cells (AdMSCs) have recently been reported. In the present study, we demonstrated a protective effect of AdMSCs in a UV irradiationinduced hairless mouse wrinkle model. Mice treated with AdMSCs showed improvements in skin erythema index, moisture capacity and transepidermal water loss. The AdMSC-treated mice showed reduced wrinkle area, as measured by gross observation and replica image analysis, and had a thinner epidermis and increased collagen and elastic fiber content, compared with the control group, as measured by histopathological examination. These results suggested that AdMSCs may be effective in the treatment of wrinkles. The activity of AdMSCs was further confirmed by the reduction in MMP-3 mRNA expression in the skin of the AdMSC treated animals, which suggests that AdMSCs can protect the collagen from degradation induced by UV irradiation. Further studies will investigate detailed mechanisms of action of AdMSCs, with particular focus on AdMSC-derived secretory factors.
Bae, Hyo-Kyung,Kim, Soo-Hyun,Lee, Sung-Young,Hwang, In-Sun,Park, Choon-Keun,Yang, Boo-Keun,Cheong, Hee-Tae The Korean Society of Animal Reproduction 2013 Reproductive & developmental biology Vol.37 No.1
The present study was conducted to examine the effect of antioxidant treatment during parthenogenetic activation procedure on the reactive oxygen species (ROS) levels and in vitro development of porcine parthenogenetic embryos. Porcine in vitro matured oocytes were activated by a combination of electric stimulus and 2 mM 6-dimethylaminopurine (6-DAMP) before in vitro culture. During the activation period, oocytes were treated with $50{\mu}M$ ${\beta}$-mercaptoethanol (${\beta}$-ME), $100{\mu}M$ L-ascorbic acid (Vit. C) or $100{\mu}M$ L-glutathione (GSH). To examine the ROS level, porcine parthenogenetic embryos were stained in $10{\mu}M$ dichlorohydrofluorescein diacetate ($H_2DCFDA$) dye 20 h after culture, examined under a fluorescence microscope, and the fluorescence intensity (pixels) were analyzed in each embryo. The parthenogenetic embryos were cultured for 6 days to evaluate the in vitro development. The apoptosis was measured by TUNEL assay. The $H_2O_2$ levels of parthenogenetic embryos were significantly lower in antioxidant treatment groups ($26.9{\pm}1.6{\sim}29.1{\pm}1.3$ pixels/embryo, p<0.05) compared to control ($33.2{\pm}1.7$ pixels/embryo). The development rate to the blastocyst stage was increased in antioxidant treatment groups (32.0~32.5%) compared to control (26.9%, p<0.05), although, there was no difference in apoptosis among groups. The result suggests that antioxidant treatment during parthenogenetic activation procedure can inhibit the ROS generation and enhance the in vitro development of porcine parthenogenetic embryos.
Neuropathologic and Clinical Features of Human Medial Temporal Lobe Epilepsy
Bae, Eun-Kee,Jung, Keun-Hwa,Chu, Kon,Lee, Soon-Tae,Kim, Jin-Hee,Park, Kyung-Il,Kim, Manho,Chung, Chun-Ki,Lee, Sang Kun,Roh, Jae-Kyu 대한신경과학회 2010 Journal of Clinical Neurology Vol.6 No.2
<P><B>Background and Purpose</B></P><P>There is recent evidence of various types of morphological changes in the hippocampus of a rodent model of medial temporal lobe epilepsy (mTLE). However, little is known about such changes in humans. We examined the histological changes [i.e., neuronal loss, cell genesis, and granule cell dispersion (GCD)] in surgical hippocampal specimens taken from patients with mTLE.</P><P><B>Methods</B></P><P>Nissl staining, and nestin and Prox1 immunohistochemistry were performed on human hippocampal specimens obtained from patients with medically intractable mTLE, thus allowing the analysis of neuronal loss, cell genesis, and GCD, respectively. We also assessed the correlations between clinical parameters and the histopathologic findings.</P><P><B>Results</B></P><P>The degree of cell genesis in the granule cell layer was significantly correlated with the severity of GCD, history of childhood febrile seizures, and frequent generalized seizures. Cell genesis was not correlated with cell death, age at seizure onset, duration of epilepsy, or the mean frequency of all seizures.</P><P><B>Conclusions</B></P><P>Our results indicate that cell genesis in the dentate gyrus of patients with mTLE is associated with GCD and is influenced by the presence of febrile seizures during childhood and the frequency of episodes of generalized seizures.</P>
Accuracy Analysis of Image Orientation Technique and Direct Georeferencing Technique
Bae Sang-Keun,Kim Byung-Guk Korea Spatial Information Society 2005 한국공간정보학회지 Vol.13 No.4
모바일매핑시스템은 차량에 GPS(Global Positioning System), IMU(Inertial Measurement Unit), CCD 등을 탑재하고 대상에 관한 위치 및 영상 정보를 취득하는 효율적인 시스템이다. 모바일매핑시스템은 현재 도로 시설물 관리, 지도 갱신 등 다양한 분야에 활용되고 있으며 앞으로 그 활용도가 더욱 증가할 것으로 보인다. 항공사진측량과 같은 기존의 일반적인 사진측량의 경우, 영상 외부표정요소를 구하기 위해서는 지상기준점이 필요하다. 이러한 기준점들은 자료취득 전후에 현장측량을 통해 좌표가 결정되는데 일반적으로 많은 비용과 시간이 소요되고, 사실 영상을 취득할 도로를 따라 필요한 만큼 충분히 많은 기준점을 설치한다는 것도 거의 불가능하다. 하지만 모바일매핑 시스텔의 경우 GPS/INS를 이용해 영상촬영당시의 카메라의 위치 및 자세, 즉 외부표정요소를 직접적으로 구할 수 있어 시간과 비용 면에서 훨씬 효율적이다. 즉 외부표정요소를 결정하기 위해 영상표정기법은 지상기준점이 필요한 반면, 직접위치참조기법은 GPS/INS를 이용해 직접 외부표정요소를 구할 수 있다. 본 논문에서는 영상표정 기법과 직접위치참조기법에서 산출되는 영상외부표정요소를 이용해 지상점의 위치정확도에 대해 비교 분석해 보았다. Mobile Mapping Systems are effective systems to acquire the position and image data using vehicle equipped with the GPS (Global Positioning System), IMU (Inertial Measurement Unit), and CCD camera. They are used in various fields of road facility management, map update, and etc. In the general photogrammetry such as aerial photogrammetry, GCP (Ground Control Point)s are needed to compute the image exterior orientation elements (the position and attitude of camera). These points are measured by field survey at the time of data acquisition. But it costs much time and money. Moreover, it is not possible to make sufficient GCP as much as we want. However Mobile Mapping Systems are more efficient both in time and money because they can obtain the position and attitude of camera at the time of photographing. That is, Image Orientation Technique must use GCP to compute the image exterior orientation elements, but on the other hand Direct Georeferencing can directly compute the image exterior orientation elements by GPS/INS. In this paper, we analyze about the positional accuracy comparison of ground point using the Image Orientation Technique and Direct Georeferencing Technique.
Bae, Ji-Suk,Park, Jung-Han,Park, Yoo-Keun,Kim, Jong-Yeon,Lee, Sang-Won,Park, Soon-Woo The Korean Society for Preventive Medicine 2011 Journal of Preventive Medicine and Public Health Vol.44 No.3
Objectives: This study measured the impact of shifts in maternal age and parity on the increase in the low birth weight (LBW) rate in Korea. Methods: We obtained raw data for all 6 397 945 live births registered at the Korea National Statistical Office between 1995 and 2005. We calculated the proportion of increment in the LBW rate due to changes in the distribution of maternal age and parity (AP-dis) and the proportion due to changes in the age- and parity-specific LBW rate (AP-spe). Results: The LBW rate increased from 3.02% in 1995 to 4.28% in 2005. The multiple birth rate increased from 1.32% to 2.19% during the same period. Of the 1.26% points increment in the LBW rate, 0.64% points occurred among singleton births and 0.62% points occurred among multiple births. Changes in the AP-dis accounted for 50% of the increase in the LBW rate among singleton births, but did not contribute to the increase in the LBW rate among multiple births. The remainder of the total increment in the LBW rate was explained by the increase in the AP-spe. Conclusions: This study demonstrated that shifts in maternal age and parity among singleton births and increased multiple births were important contributors to the increment in the LBW rate. This study also revealed that the increase in the AP-spe was an equally important contributor as the shifts in maternal age and parity to the increment in the LBW rate among singleton births and was a major contributor among multiple births.
Bae, Jun Sang,Noh, Sang Jae,Jang, Kyu Yun,Park, Ho Sung,Chung, Myoung Ja,Park, Cheol Keun,Moon, Woo Sung Lychnia 2012 International journal of oncology Vol.41 No.6
<P>Epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC). However, the function and clinical significance of EpCAM in HCC is largely unknown. We examined EpCAM expression and localization in 28?dysplastic nodules (DNs) and their corresponding cirrhotic nodules, 79?HCC tissue sections and 132?HCC tissue microarray cores by immunohistochemistry and determined the relationship to clinicopathologic findings. We also examined the role of EpCAM in HCC using synthetic small interfering RNA to silence EpCAM gene expression in Huh-7 cells. EpCAM expression was very rare in DNs but dominantly appeared in a distinctly nodular type of small HCC. Expression of EpCAM was observed in 39% (31/79) of HCC tissue sections and in 34.1% (45/132) of tissue microarray sections. EpCAM expression in HCC was significantly associated with high tumor grade and serum α-fetoprotein level. Silencing EpCAM gene expression significantly decreased the proliferative activity and invasiveness of HCC cells. EpCAM expression was an independent prognostic factor for survival in patients with T1 HCC. The data indicate that EpCAM expression occurs at distinct nodular stage of HCC and could play an important role in HCC progression.</P>
Respiratory Viral Infection and Prognosis of Patients with Pneumonia in Intensive Care Unit
( Keun Bae Jeong ),( Seok Jeong Lee ),( Iseul Yu ),( Ji-ho Lee ),( Sang-ha Kim ),( Won-yeon Lee ),( Suk Joong Yong ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Respiratory viral infection is usually associated with upper respiratory infection and mild symptoms. However, some lower respiratory infections develop by viruses or their complications. The knowledge of viral contribution to pneumonia is limited. Especially in patients with pneumonia admitted in intensive care unit (ICU), impact of viral infection on the prognosis is not much investigated. We investigated to reveal the association of viral infection and ICU prognosis of pneumonia. Methods Following a retrospective review of the medical records of a single medical center from 2012 to 2017, we included adults who had pneumonia and performed respiratory viral PCR test in ICU. Results The mean age of the patients was 67 years and 62% (n = 65) was male. Of total 105 patients, 16 patients (15.2%) showed positive respiratory viral PCR. There are eight influenza, three parainfluenza, two rhinovirus, an adenovirus, a metapneumovirus, and a coronavirus. The group of positive viral PCR showed higher level of C-reactive protein (22.28±10.73 vs 14.98±10.47 mg/ dL, p=0.012), more severe disease presented by APACHE II score (21.56±9.44 vs 17.31±7.28, p=0.043), and shorter ventilator free day at 28 day (8.4±11.0 vs 14.9±12.5 days, p=0.044). In simple univariable study, ICU mortality and hospital mortality are not related with viral PCR Results. There is only trend of higher hospital mortality in the group of PCR-positive patients. In multiple logistic regression model including variables of age, sex, APACHE II score, CRP, and respiratory viral PCR, CRP (OR, 1.085; 95% CI 1.033-1.139) is associated with ICU mortality. Conclusions The result of respiratory viral PCR is not associated with ICU mortality in patient with pneumonia. However, patients admitted in ICU with pneumonia and positive viral PCR may have more severe disease and shorter ventilator-free day compared to those with pneumonia and negative viral PCR.