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A rare case of extensive papillary muscle calcification in senile cardiac calcification syndrome
김은진;송봉근;강민호;손형래;홍수민;박동원;허승혜;김계연;최석구 인제대학교 2011 仁濟醫學 Vol.32 No.-
광범위 유두근 석회화는 흔하지 앉으며, 원인과 임상적 중요성에 관한 문헌만 드물게 찾아볼 수 있다. 반면에 작은 석회 침착은 노인에서 흔하며 심장 첨부에 주로 나타난다. 유두근 석회화는 관상동맥질환, 확장성 심근병증, 승모관 질환, 고칼슘혈증, 그리고 말기신부전에서 인산칼슘의 중가와 연관성이 있다. 저자는 심장초옴파와 MDCT를 통해 진단된 전외측 유두근의 광범위 석회화의 드문 사례가 있어 보고한다.
( Ji Hye Heo ),( Seung Ha Lee ),( Kyung Ha Chang ),( Eun Hye Han ),( Seung Gwan Lee ),( Dal Woong Choi ),( Suhng Wook Kim ) 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.2
Neuropatic pain is a chronic pain disorder caused by nervous system lesions as a direct consequence of a lesion or by disease of the portions of the nervous system that normally signal pain. The spinal nerve ligation (SNL) model in rats that reflect some components of clinical pain have played a crucial role in the understanding of neuropathic pain. To investigate the direct effects of gabapentin on differential gene expression in cultured dorsal root ganglion (DRG) cells of SNL model rats, we performed a dif-ferential display reverse transcription-polymerase chain reaction analysis with random priming approach using annealing control primer. genes encoding metallon-polymerase chain reaction analysis with random priming approach using annealing control priner. Genes encoding metallothionein 1a, transforming grwth factor-β1 and palming-protein thioesterase-2 were up-regulated in gabapentin-treated DRG ceoos of SNL model rats. The functional roles of these diggerentially expressed genes were preciously suggested as neuroprotective genes. Further study of these genes is ecpected to reveal potential targets of gabbapentin.
Hye-Young Song,In-Jeoung Baek,Seung-Hee Ryu,Je-won Ryu,Eun-Young Park,Seung-Ho Heo 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Human immune system (HIS) mice have become valuable animal models for the study of human diseases, and peripheral blood mononuclear cell engrafted humanized mice (PBMCHu mice) mice provide a useful platform for cancer immunotherapy research. However, there have been limitations such as insufficient engraftment of human immune cells and development of graft versus host disease (GVHD). To overcome these limitation, we generated CD47; Rag2; IL2rg triple KO mice (TKO) using NOD-Rag2null IL2rgnull mice (DKO) and transplantation efficacy of human leukocytes and GVHD incidence were compared in PBMC-Hu mice. Examining flow cytometry results, more than 25% Human CD45+ cells were observed in both TKO groups from 3 weeks after PBMC administration, and it was observed more than 1 week later in DKO groups. Most of the engrafted cells were CD3+ T cells, and some CD19 B cells and CD66b+ granulocytes were also observed. The ratio of human leukocytes engraftment was greater in TKO mice, however, clinical symptoms of GVHD such as weight loss, jaundice, anemia and death of animals were more severe than in DKO mice. In histopathology, inflammatory cell aggregation, necrotic or apoptotic cells were observed in liver, lung and kidney, and semi-quantitative lesion scores were greater in TKO mice groups. Human CD45, CD3 and CD19 positive cells were also observed in immunohistochemistry. CD47 protein present on myeloid cells and inhibit phagocytosis through ligation of signal-regulatory protein alpha (SIRPα). In this study, we generate TKO mice to improve PBMC-Hu mice. Engraftment of human leukocytes was increased, but symptoms of GVHD were also more severe in TKO mice than DKO mice. Further study for overcoming development of GVHD and poor engraftment of leukocytes other than T cells is needed.
Heo, Nam Su,Shukla, Shruti,Oh, Seo Yeong,Bajpai, Vivek K.,Lee, Sun Uk,Cho, Hye-Jin,Kim, Suji,Kim, Yeonho,Kim, Hae Jin,Lee, Sang Yup,Jun, Young-Si,Oh, Mi-Hwa,Han, Young-Kyu,Yoo, Seung Min,Huh, Yun Suk Elsevier 2019 Materials Science and Engineering C Vol. No.
<P><B>Abstract</B></P> <P>Bacterial pathogens of water origin have potential public threats thus suggesting the need of developing efficient and sustainable water disinfection strategies from waterborne pathogens. We set out to synthesize different controlled morphologies of graphitic carbon nitride (g-C<SUB>3</SUB>N<SUB>4</SUB>) polymer, evaluate their comparative effects on the generation of reactive oxygen species (ROS), and investigate potential applications in water purification systems. Characterization of the synthesized microstructures of g-C<SUB>3</SUB>N<SUB>4</SUB>, such as melamine-cyanuric acid (MCA)-based rosette-type, rod-type, 2D hexagonal, and 3D cubic mesoporous silica was accomplished using Fourier transform infrared (FT-IR), energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), X-ray diffractometry (XRD), and transmission electron microscopy (TEM). The microbial inhibitory potential of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> photocatalyst against waterborne <I>Escherichia coli</I>, <I>Staphylococcus aureus</I>, and <I>Salmonella typhimurium</I> was evaluated based on the effective activity of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> upon visible light excitations. The microbicidal efficiency of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> was evident within 30 min of visible light exposure via direct interaction, while other microstructures of g-C<SUB>3</SUB>N<SUB>4</SUB> demonstrated only slight antimicrobial effects after 120 min, with insufficient ROS generation. The antimicrobial and ROS-generating effects of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> depended on the type and surface area of the synthesized 2D g-C<SUB>3</SUB>N<SUB>4</SUB> material. Considering its availability and excellent disinfection activity, 2D g-C<SUB>3</SUB>N<SUB>4</SUB> obtained from simple and convenient facile synthesis is a promising solar-driven photocatalyst for clearing microbial contamination from water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Waterborne pathogenic bacteria pose significant health risks to the public. </LI> <LI> We synthesized different morphologies of graphitic carbon nitride (g-C<SUB>3</SUB>N<SUB>4</SUB>) polymer. </LI> <LI> Synthesized microstructures of g-C<SUB>3</SUB>N<SUB>4</SUB> had potential effect on ROS generation. </LI> <LI> 2D hexagonal g-C<SUB>3</SUB>N<SUB>4</SUB> exhibited significant antimicrobial potential. </LI> <LI> 2D g-C<SUB>3</SUB>N<SUB>4</SUB> had photocatalytic inactivation efficiency in a water purifying system. </LI> </UL> </P>
( Seung Hye Lee ),( Jung Hoi Koo ),( Yeon Mi Lim ),( So Nam Kim ),( Yong Heo ) 한국동물실험대체법학회 2007 한국동물실험대체법학회 학술대회집 Vol.2007 No.1
Prior to systemic investigation on intense husbandry environment-mediated stress outcome in pig or hen, we compared serum levels of epinephrine, norepinephrine, and cortisol in pigs or hens housed in intense husbandry confinement building or environmentally friendly husbandry facility. Pigs were accommodated under density of 3 per 3.3 ㎡and were kept on wet floors in the intense husbandry confinement building with fan-ventilation system. Meanwhile, the environmentally friendly husbandry facility with open ventilation system accommodated 2 pigs per 3.3 ㎡and pigs were kept on dry floors. Hens were housed under density of 3 per 0.1 ㎡in wire-partitioned battery cage at the intense husbandry confinement building with fan-ventilation system. Meanwhile, the environmentally friendly husbandry facility with open ventilation system accommodated 11 hens per 3.3 ㎡on flat ground. Five animals from each facility were randomly chosen and their peripheral blood was collected from jugular vein in pig or wing vein in hen. Levels of epinephrine, norepinephrine, and cortisol were determined using commercially available ELISA kit. Pigs housed in the intense husbandry confinement building demonstrated 10-fold and 6-fold lower level of epinephrine and norepinephrine, respectively, than those in the environmentally friendly husbandry facility. Furthermore, level of cortisol was significantly lowered in both pigs and hens housed in the intense husbandry confinement building, compared with that in the environmentally friendly husbandry facility. Overall our results suggest that pigs and hens housed in the intense husbandry confinement building are not adequately responding to extrinsic stress such as manual bleeding, eventually leading to vulnerability to various diseases.
[P347] Iatrogenic kaposi sarcoma by capecitabine
( Seung Dohn Yeom ),( Ji Hye Heo ),( Hee Sung Yoon ),( Si Hyub Lee ),( Ji Won Byun ),( Gwang Seong Choi ),( Jeonghyun Shin ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Kaposi sarcoma (KS) is a lymphoangioproliferative neoplasm induced by human herpes virus 8 (HHV-8). Four clinical variants have been recognized: classical, African endemic, AIDS-related, and KS induced by iatrogenic immunocompression. The latter is typically associated with the use of immunosuppressive therapy in organ transplant recipients, cancer and autoimmune disorders. It shows painless purplish-red patches or nodules particularly on the lower limb, especially toes and soles. We describe a 61-year-old man presented with asymptomatic dusky erythematous patches on the left toes and asymptomatic dusky erythematous nodule on the left ear-helix for a month. He had been diagnosed with rectosigmoid cancer 16 months ago and treated with chemotherapy (capecitabine, Xelobig<sup>®</sup>) before the visit to the dermatologic outpatient clinic. Histopathological findings of the left ear-helix lesion revealed that spindle cell proliferations in dermis and irregular vascular structures among collagen bundles. In immunohistochemical staining, CD31 and HHV-8 were positive. The lesions improved without specific treatment within 2 months after discontinuation of capecitabine. To the best of our knowledge, this is the second case of iatrogenic KS induced by chemotherapy and the first case induced by capecitabine in Korean dermatologic literature.