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Truong Giang Nguyen,Thanh Khiem Nguyen,Ham Hoi Nguyen,Hong Son Trinh,Tuan Hiep Luong,Minh Trong Nguyen,Van Duy Le,Hai Dang Do,Kieu Hung Nguyen,Van Minh Do,Quang Huy Tran,Cuong Thinh Nguyen 한국간담췌외과학회 2024 Annals of hepato-biliary-pancreatic surgery Vol.28 No.1
Backgrounds/Aims: Parenchymal-sparing anatomical hepatectomy (Ps–AH) based on portal ramification of the right anterior section (RAS) is a new technique to avoid unnecessarily transecting too much liver parenchyma, especially in cases of major anatomical hepatectomy. Methods: We prospectively assessed 26 patients with primary hepatic malignancies having undergone major Ps–AH based on portal ramification of the RAS from August 2018 to August 2022 (48 months). The perioperative indications, clinical data, intra-operative index, pathological postoperative specimens, postoperative complications, and follow-up results were retrospectively evaluated. Results: Among the 26 patients analyzed, there was just one case that had intrahepatic cholangiocarcinoma The preoperative level of α– Fetoprotein was 25.2 ng/mL. All cases (100%) had Child–Pugh A liver function preoperatively. The ventral/dorsal RAS was preserved in 19 and 7 patients, respectively. The mean surgical margin was 6.2 mm. The mean surgical time was 228.5 minutes, while the mean blood loss was 255 mL. In pathology, 5 cases (19.2%) had microvascular invasion, and in the group of HCC patients, 92% of all cases had moderate or poor tumor differentiation. Six cases (23.1%) of postoperative complications were graded over III according to the Clavien–Dindo system, including in three patients resistant ascites or intra-abdominal abscess that required intervention. Conclusions: Parenchymal-sparing anatomical hepatectomy based on portal ramification of the RAS to achieve R0-resection was safe and effective, with favorable short-term outcomes. This technique can be used widely in clinical practice.
PS-anchored imidazole-based ionic liquids for generating diureas
( Nguyen Duy Son ),김용진,( Tran Anh Vy ) 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Urea and its substituted derivatives are playing important role in chemical industry for many decades [1]. However, for a long time, these useful substances have been prepared by the coupling reaction between amines and phosgene. In order to avoid using harmful agent, greener and economic routes have been investigated by numerous researchers. During the last decades, enormous works have been done on finding a homogenous catalyst for this transformation, however, heterogeneous catalysts still have not intensively developed - only a few active solid bases have been published such as CeO<sub>2</sub>, Cs<sub>2</sub>CO<sub>3</sub> in NMP and PEG/KOH system [2]. Here we present a novel heterogeneous catalyst system comprising polystyrene- anchored matrices and basic ionic liquids as simple but highly regenerative catalyst for the synthesis of diureas from direct coupling reactions of various amines and CO<sub>2</sub>.
Van Duy, Nguyen,Jung, Sungwook,Kim, Kwangryul,Son, Dang Ngoc,Nga, Nguyen Thanh,Cho, Jaehyun,Choi, Byoungdeog,Yi, Junsin Institute of Physics [etc.] 2010 Journal of physics. D, applied physics Vol.43 No.7
<P>Silicon-rich SiO<SUB><I>x</I></SUB> material is a good charge storage candidate for memory applications that promise a large memory window and low operation voltage. Nonvolatile memory (NVM) devices fabricated on excimer laser-annealed polysilicon using SiO<SUB>2</SUB>/SiO<SUB><I>x</I></SUB>/SiO<SUB><I>x</I></SUB>N<SUB><I>y</I></SUB> (OOxOn) structure are investigated with SiO<SUB>2</SUB> blocking thicknesses changing from 15 to 20 to 30 nm. The Si-rich SiO<SUB><I>x</I></SUB> material exposed numerous non-bridging oxygen hole-centre defect sources and a rich silicon phase in the base material. These defects, as well as amorphous silicon clusters existing in the SiO<SUB><I>x</I></SUB> layer, enhance the charge storage capacity of the device. Retention properties were ensured by 3.2 nm SiO<SUB><I>x</I></SUB>N<SUB><I>y</I></SUB> tunnelling layer growth via N<SUB>2</SUB>O plasma-assisted oxynitridation. NVM characteristics showed a retention exceeding 85% of the threshold voltage shift after 10<SUP>4</SUP> s and greater than 70% after 10 years. Depending on the blocking thickness of 15, 20 or 30 nm, operating voltages varied from ±9 to ±13 V at a programming/erasing duration of only 1 ms. These excellent operating properties of the OOxOn structure make it a potential competitor among the new generation of memory structures on glass.</P>
Van Duy, Nguyen,Jung, Sungwook,Nga, Nguyen Thanh,Son, Dang Ngoc,Cho, Jaehyun,Lee, Sunhwa,Lee, Wonbaek,Yi, Junsin Elsevier 2010 Materials science and engineering B. Advanced Func Vol.175 No.2
<P><B>Abstract</B></P><P>Beside silicon nitride, silicon rich SiO<SUB><I>x</I></SUB> is a good charge storage material for the charge trap type of nonvolatile memory due to the high density of the charge traps. In this study, the charge storage ability of various amorphous SiO<SUB><I>x</I></SUB> materials has been investigated. By controlling the ratio of N<SUB>2</SUB>O/SiH<SUB>4</SUB> gases from a 1:6 to a 2:1 input gas flow rate, the deposited SiO<SUB><I>x</I></SUB> bandgap changed from 2.3 to 3.9eV. The charge storage properties of the SiO<SUB><I>x</I></SUB> system were studied on metal–insulator–semiconductor structures with an insulator stack of SiO<SUB>2</SUB>/SiO<SUB><I>x</I></SUB>/SiO<SUB><I>x</I></SUB>N<SUB><I>y</I></SUB> on an n-type silicon wafer. In this structure, the SiO<SUB>2</SUB> was used for the blocking layer and the SiO<SUB><I>x</I></SUB>N<SUB><I>y</I></SUB> was used for the tunneling layer. By analyzing the FTIR and the photoluminescence spectra, it is shown that the richest silicon material incorporates numerous non-bridging oxygen hole-center (NBOHC) defect sources and a rich silicon phase in the base material. These defects, as well as the amorphous silicon clusters that exist in the SiO<SUB><I>x</I></SUB> layer, enhanced the charge storage capacity of the device compared to the oxygen rich SiO<SUB><I>x</I></SUB> cases. The retention property was optimized by surveying the tunneling thickness of the 2.3, 2.6, 2.9, and 3.2nm SiO<SUB><I>x</I></SUB>N<SUB><I>y</I></SUB> layers.</P>
Thanh Khiem Nguyen,Ham Hoi Nguyen,Tuan Hiep Luong,Kim Khue Dang,Van Duy Le,Duc Dung Tran,Van Minh Do,Hong Quang Pham,Hoan My Pham,Thi Lan Tran,Cuong Thinh Nguyen,Hong Son Trinh,Yosuke Inoue 한국간담췌외과학회 2024 Annals of hepato-biliary-pancreatic surgery Vol.28 No.1
Backgrounds/Aims: Pancreaticoduodenectomy (PD) is the only radical treatment for periampullary malignancies. Superior mesenteric artery (SMA) first approach combined with total meso-pancreas (MP) excision was conducted to improve the oncological results. There has not been any previous research of a technique that combines the SMA first approach and total MP excision with a detailed description of the MP macroscopical shape. Methods: We prospectively assessed 77 patients with periampullary malignancies between October 2020 and March 2022 (18 months). All patients had undergone PD with SMA first approach combined total MP excision. The perioperative indications, clinical data, intra-operative index, R0 resection rate of postoperative pathological specimens (especially mesopancreatic margin), postoperative complications, and follow-up results were evaluated. Results: The median operative time was 289.6 min (178−540 min), the median intraoperative blood loss was 209 mL (30−1,600 mL). Microscopically, there were 19 (24.7%) cases with metastatic MP, and five cases (6.5%) with R1-resection of the MP. The number of lymph nodes (LNs) harvested and metastatic LNs were 27.2 (maximum was 74) and 1.8 (maximum was 16), respectively. Some (46.8%) patients had pancreatic fistula, but mostly in grade A, with 7 patients (9.1%) who required re-operations. Some 18.2% of cases developed postoperative refractory diarrhea. The rate of in-hospital mortality was 1.3%. Conclusions: The PD with SMA first approach combined TMpE for periampullary malignancies was effective in achieving superior oncological statistics (rate of MP R0-resection and number of total resected LNs) with non-inferior short-term outcomes. It is necessary to evaluate survival outcomes with long-term follow-up.
Son, Dang Ngoc,Van Duy, Nguyen,Jung, Sungwook,Yi, Junsin Institute of Physics 2010 Semiconductor science and technology Vol.25 No.8
<P>Nonvolatile memory (NVM) devices with a nitride–nitride–oxynitride stack structure on a rough poly-silicon (poly-Si) surface were fabricated using a low-temperature poly-Si (LTPS) thin film transistor technology on glass substrates for application of flat panel display (FPD). The plasma-assisted oxidation/nitridation method is used to form a uniform oxynitride with an ultrathin tunneling layer on a rough LTPS surface. The NVMs, using a Si-rich silicon nitride film as a charge-trapping layer, were proposed as one of the solutions for the improvement of device performance such as the program/erase speed, the memory window and the charge retention characteristics. To further improve the vertical scaling and charge retention characteristics of NVM devices, the high-κ high-density N-rich SiN<I><SUB>x</SUB></I> films are used as a blocking layer. The fabricated NVM devices have outstanding electrical properties, such as a low threshold voltage, a high ON/OFF current ratio, a low subthreshold swing, a low operating voltage of less than ±9 V and a large memory window of 3.7 V, which remained about 1.9 V over a period of 10 years. These characteristics are suitable for electrical switching and data storage with in FPD application.</P>
Hydrogel Encapsulation of Cells in Core-Shell Microcapsules for Cell Delivery
Nguyen, Duy Khiem,Son, Young Min,Lee, Nae-Eung Wiley (John WileySons) 2015 Advanced Healthcare Materials Vol.4 No.10
<P>A newly designed 3D core-shell microcapsule structure composed of a cell-containing liquid core and an alginate hydrogel shell is fabricated using a coaxial dual-nozzle electrospinning system. Spherical alginate microcapsules are successfully generated with a core-shell structure and less than 300 μm in average diameter using this system. The thickness of the core and shell can be easily controlled by manipulating the core and shell flow rates. Cells encapsulated in core-shell microcapsules demonstrate better cell encapsulation and immune protection than those encapsulated in microbeads. The observation of a high percentage of live cells (?80%) after encapsulation demonstrates that the voltage applied for generation of microcapsules does not significantly affect the viability of encapsulated cells. The viability of encapsulated cells does not change even after 3 d in culture, which suggests that the core-shell structure with culture medium in the core can maintain high cell survival by providing nutrients and oxygen to all cells. This newly designed core-shell structure can be extended to use in multifunctional platforms not only for delivery of cells but also for factor delivery, imaging, or diagnosis by loading other components in the core or shell.</P>