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Case Reports : Moyamoya disease and adrenal adenoma with severe pre-eclampsia
Eun Young Park,Naomi Hyon,Chul Jong Park,Kyung Hee Han,Seong Jin Choi 대한산부인과학회 2009 Journal of Womens Medicine Vol.2 No.3
Moyamoya disease is a rare, progressive, occlusive cerebrovascular disease with characteristic angiographic findings. Factors such as pregnancy and childbirth can increase the risk of ischemic or hemorrhagic stroke associated with this disease. Additionally if hypertension develops during pregnancy, a thorough elucidation of its cause and strict monitoring and/or control may be necessary. Adrenal adenomas during pregnancy are very rare and their the diagnosis is much more difficult during pregnancy. We have described a case involving the delayed diagnosis of Moyamoya disease and adrenal adenoma in a woman with severe pre-eclampsia. If any abnormal neurologic sign is noted in woman with pre-eclampsia, the possibility that other cases of stroke exist should be considered.
참외추출물이 스코폴라민 유도 기억상실 흰쥐의 인지능 회복에 미치는 효과
박상신(Sang-Shin Park),박나오미(Naomi Park),강주억(Ju-Uk Kang),신석철(Suk-Chul Shin),이동웅(Dong-Ung Lee) 한국생명과학회 2009 생명과학회지 Vol.19 No.5
The methanol extract of muskmelon (Cucumis melo) has been investigated for its cognition enhancing effects by evaluation of inhibitory activities on acetylcholinesterase, a degrading enzyme of acetylcholine, a brain neurotransmitter, and β-secretase, which forms the β-amyloid toxic protein from its precursor protein. A passive avoidance task, one of the animal model experiments for learning and memory, was also performed. As a result, the melon extract showed 15.8% and 35.3% inhibition on acetylcholinesterase and β-secretase, respectively, with a final concentration of 100 ㎎/ml. In the animal model test, melon extract significantly (p<0.05) lengthened the step-through latency time by 22.7% compared to the control group, suggesting that melon extract has, indeed, an effect on cognition enhancement.
( Naomi Nahyoung Hyon ),( Chul Jong Park ),( Jeong Yeun Kim ),( Hyuck Dong Han ),( Kyoung Hee Han ) 대한산부인과학회 2011 Journal of Womens Medicine Vol.4 No.2
Laparoscopic techniques are frequently employed in gynecology for the treatment of clinically benign ovarian masses. Although rare, the possibility of malignancy must always be considered and tumor contents handled with care upon removal of clinically benign masses. Port-site metastasis is a rare but potential complication following laparoscopic surgery for gynecological malignancies. Malignant transformation of mature cystic teratoma is uncommon, occurring in only 1-2% of cases. Squamous cell carcinoma is the most common type of malignancy to arise from mature cystic teratoma. We present a rare case of port site metastasis of squamous cell carcinoma arising from a presumably benign teratoma after laparoscopic resection.
DHEA administration has limited effect onintestinal Ca absorption in ovariectomized rats
( Jong Hoon Park ),( Naomi Omi ) 한국운동영양학회 2014 Physical Activity and Nutrition (Phys Act Nutr) Vol.18 No.4
[Purpose] The effect of dehydroepiandrosterone (DHEA) administration on intestinal Calcium (Ca) absorption in estrogen deficiency state has not been studied yet. We examined the bone mineral content (BMC) of lumbar spine and Ca balance such as intestinal Ca absorption and Ca accumulation in ovariectomized (OVX) rats after 8 weeks of DHEA administration. [Methods] Seventeen female Sprague-Dawley rats, 6 weeks old, were randomized into two groups: OVX control rats (OC, n = 8) and OVX rats with DHEA treatment (OD, n = 9). DHEA was administered to the OD group intraperitoneally at 20 mg DHEA/kg body weight for 8 weeks while the OC group was treated with vehicle only. [Results] The BMC normalized by body weight of the lumbar spine (trabecular-abundant region) in the OD group was found to be significantly higher compared to that in the OC group. The femoral wet weight normalized by body weight in the OD group was significantly higher compared to that in the OC group. The intestinal Ca absorption, rate of intestinal Ca absorption, Ca accumulation, and rate of Ca accumulation decreased from the 4th and 5th of the experimental diet period to the end of the experimental period, but interaction of time and group was not observed. In both periods, all parameters did not differ between the groups. [Conclusion] The present study confirmed the positive effect of DHEA on trabecular bone mass in ovariectomized rats. On the other hand, DHEA administration might have limited the impact on intestinal Ca absorption in estrogen deficiency state.
Han, Jeong Hee,Park, Jung Duck,Sakai, Kiyoshi,Hisanaga, Naomi,Chang, Hee Kyung,Lee, Yong Hwan,Kwon, Il Hoon,Choi, Byung Sun,Chung, Yong Hyun,Kim, Hyeon Yeong,Yang, Jung Sun,Cho, Myung Haing,Yu, Il Je Informa UK (TaylorFrancis) 2009 Journal of toxicology and environmental health. Pa Vol.72 No.21
<P>To evaluate the effects of environmental asbestos exposure on the inducement of lung cancer, pulmonary asbestos and non-asbestos fiber content was determined in 36 normal Korean subjects and 38 lung cancer subjects with no known occupational history of asbestos exposure. Pulmonary asbestos fiber content was measured by transmission electron microscopy (TEM) with energy-dispersive x-ray analysis after applying a low-temperature ashing procedure. Chrysotile fibers were the major fiber type found in the lungs of the Korean subjects. The asbestos fiber concentrations found in the lungs of normal males (25) and females (11) were 0.26 x 10(6) fibers/g of dry lung tissue and 0.16 x 10(6) fibers/g of dry lung tissue, respectively. The asbestos concentrations found in the lungs of cancer subjects were 0.16 x 10(6) fibers/g of dry lung tissue for 32 males and 0.44 x 10(6) fibers/g of dry lung tissue for 6 females. No statistical difference was found in pulmonary asbestos content between the normal and lung cancer subjects, whereas a statistical difference was noted between normal and lung cancer subjects with respect to lung non-asbestos content, indicating a potential role for non-asbestos fibers being associated with lung cancer.</P>
Risk Assessment of Baby Powder Exposure through Inhalation
Moon, Min-Chaul,Park, Jung-Duck,Choi, Byung-Soon,Park, So-Young,Kim, Dong-Won,Chung, Yong-Hyun,Hisanaga, Naomi,Yu, Il-Je Korean Society of ToxicologyKorea Environmental Mu 2011 Toxicological Research Vol.28 No.3
This study was conducted to assess the exposure risk through inhalation to baby powder for babies and adults under simulated conditions. Baby powder was applied to a baby doll and the amount of baby powder consumed per application was estimated. The airborne exposure to baby powder during application was then evaluated by sampling the airborne baby powder near the breathing zones of both the baby doll and the person applying the powder (the applicator). The average amount of baby powder consumed was 100 mg/application, and the average exposure concentration of airborne baby powder for the applicator and baby doll was 0.00527 mg/$m^3$ (range 0.00157~0.01579 mg/$m^3$) and 0.02207 mg/$m^3$ (range 0.00780~0.04173 mg/$m^3$), respectively. When compared with the Occupational Exposure Limit of 2 mg/$m^3$ set by the Korean Ministry of Labor and the Threshold Limit Value (TLV) of 2 mg/$m^3$ set by the ACGIH (American Conference of Governmental Industrial Hygienists), the exposure concentrations were much lower. Next, the exposure to asbestos-containing baby powder was estimated and the exposure risk was assessed based on the lung asbestos contents in normal humans. As a result, the estimated lung asbestos content resulting from exposure to asbestos-containing baby powder was found to be much lower than that of a normal Korean with no asbestos-related occupational history.
( Satoshi Hattori ),( Suhan Park ),( Jong-hoon Park ),( Naomi Omi ) 한국운동영양학회 2020 Physical Activity and Nutrition (Phys Act Nutr) Vol.24 No.4
[Purpose] Dehydroepiandrosterone (DHEA) administration reportedly recovers osteoporosis, a bone disorder associated with bone deficiency in postmenopausal women. However, the physiological mechanism of DHEA in osteoporosis remains elusive, especially in terms of intestinal calcium absorption. Therefore, we investigated the effect of DHEA administration on calcium absorption in ovariectomized (OVX) female rats using an estrogen receptor antagonist. [Methods] Female Sprague-Dawley rats (n=23, 6 weeks old) were randomized into three groups: OVX control group (OC, n=7), OVX with DHEA treatment group (OD, n=8), and OVX with DHEA inhibitor group (ODI, n=8) for 8 weeks. [Results] Intestinal calcium accumulation, as well as the rate of absorption, demonstrated no significant differences during the experimental period among investigated groups. The bone mineral density (BMD) of the tibia at the proximal metaphysis was higher in the OD group than that in the OC group (p<0.05); however, BMD of the ODI group showed no significant difference from investigated groups. Furthermore, the BMD of the tibia at the diaphysis did not significantly differ among these groups. [Conclusion] We revealed that DHEA administration does not involve intestinal Ca absorption, although this treatment improves BMD levels in OVX rats. These observations indicate that the effect of DHEA on the bone in postmenopausal women is solely due to its influence on bone metabolism and not intestinal calcium absorption.
Mishima, Nobuo,Miyamoto, Naomi,Taguchi, Yoko,Kitagawa, Keiko,Oh, Yong-Sun,Park, Sun Gyu The Korea Contents Association 2013 International Journal of Contents Vol.9 No.2
It has been determined that two-way evacuation routes that connect houses to evacuation sites should be developed to protect residents of historic preservation areas from future disasters. These routes are required because traditional buildings and other historic spatial elements are located close to each other. It is important to understand residents' perceptions of evacuation routes that connect their houses to temporary safe places to develop evacuation system strategies that include effective two-way evacuation routes. This paper describes a procedure used to construct a two-way evacuation route database designed to preserve two study areas that was based on an interview survey conducted with area residents. The resulting database contained residents' perceptions of evacuation routes. The database contains categorized spatial problems related to these routes that can be used for future research.
Risk Assessment of Baby Powder Exposure through Inhalation
Min Chaul Moon,Jung Duck Park,Byung Soon Choi,So Young Park,Dong Won Kim,Yong Hyun Chung,Naomi Hisanaga,Il Je Yu 한국독성학회 2011 Toxicological Research Vol.27 No.3
This study was conducted to assess the exposure risk through inhalation to baby powder for babies and adults under simulated conditions. Baby powder was applied to a baby doll and the amount of baby powder consumed per application was estimated. The airborne exposure to baby powder during application was then evaluated by sampling the airborne baby powder near the breathing zones of both the baby doll and the person applying the powder (the applicator). The average amount of baby powder consumed was 100 ㎎/application, and the average exposure concentration of airborne baby powder for the applicator and baby doll was 0.00527 ㎎/㎥ (range 0.00157~0.01579 ㎎/㎥) and 0.02207 ㎎/㎥ (range 0.00780~0.04173 ㎎/㎥), respectively. When compared with the Occupational Exposure Limit of 2 ㎎/㎥ set by the Korean Ministry of Labor and the Threshold Limit Value (TLV) of 2 ㎎/㎥ set by the ACGIH (American Conference of Governmental Industrial Hygienists), the exposure concentrations were much lower. Next, the exposure to asbestos-containing baby powder was estimated and the exposure risk was assessed based on the lung asbestos contents in normal humans. As a result, the estimated lung asbestos content resulting from exposure to asbestos-containing baby powder was found to be much lower than that of a normal Korean with no asbestos-related occupational history.