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분획으로 분리한 Streptococcus mutans KCTC 3065 다당류의 화학적 특성
한만덕,이준우,나수정,이은숙,전은숙 대한구강보건학회 2000 大韓口腔保健學會誌 Vol.24 No.3
The oral micro-organism Streptococcus mutans synthesizes extracellular glucosyltransferase(GTFs) which polymerize the glucose moiety of sucrose into glucan polymers. These glucan was known to cause dental caries. The study was set up to elucidate the chemical properties of polysaccharides obtained from the cell wall(CWP) and extracellular polysaccharides(ECP) of S. mutans KCTC 3065 polysaccharides. The recovery rate(%) of extracellular and cell wall polysaccharides were purified of 0.032% and 0.13% of total polysaccharide(dry weight), respectively. CWP fraction was determined to be approximately average 70 kilodalton by gel filtration, contains 62.2% of D-glucose and 38.9% of galactose. Whereas, ECP appears approximately average 60kD by gel filtration, and contains exclusively α-D-glucose, fructose and mannose.
Ganoderma lucidum 세포외성 다당류의 화학적 특성
한만덕 김천대학교 1998 김천대학교 논문집 Vol.19 No.-
The polysaccharide of Basidiomycetes induces potent antitumor immunity in tumor-bearing mice
고등균류에서 분리한 열수추출물의 in vitro 항암효과
한만덕 김천대학교 2016 김천대학교 논문집 Vol.21 No.-
The extract of Basidiomycetes induces potent antitumor immunity in tumor-bearing mice. The study was set up to elucidate the anti-cancer effects of various mushroom extract against human cancer cell lines. The mushroom extract was prepared from the fruit body of many types of Basidiomycetes: Poria cocos, Ganoderma lucidum, Ganoderma oregonence. Ganoderma applanatum, Ganoderma tusgae. Fomitella fraxinea. Laetiporus sulphureus, Phellinus lintenus, Agaricus brazei. Most extracts showed cytotoxicity on human cancer cell line: hepatocytoma (SNU 387), human colon carcinoma (SNU C4)and human gastric adenocarcinoma (SNU-1). The highest anticancer effect(83.1% cytotoxicity) of tested samples occurs with Ganoderma applanatum extract on human hepatocytoma SNU 387 cell line. In conclusion, the low molecular extract(<10,000 M. W) of Basidiomycetes hot extract was higher anticancer effect than that the high molecular()10.000 M. W) extract on A549, SNU-1, SNU C4. and SNU 387 human cancer cell line.
Ganoderma lucidum 군사체성 다당류를 이용한 식이섬유소의 개발
한만덕 김천대학교 2001 김천대학교 논문집 Vol.22 No.-
The dietary fiber(GLD-06), β-glucanic polysaccharide, from the mycelium of Ganoderma lucidum was fractionated by the sequential use of salts and hot extraction and obtained 0.35% of yield from the mycelial culture medium.
Ganoderma lucidum의 세포외성 다당류의 생리활성
한만덕 김천대학교 1999 김천대학교 논문집 Vol.20 No.-
Antitumor polysaccharides were known to activate complement system and incease pecific serum proteins in mouse, and some researcher reported that antitumor activity of polysaccharides might be correlated and macrophage. The b-glucan of G. ucidum induces potent antitumor evaluate the bioactivities of extracellular polysaccharide obtaioned from the mycelia of G. lucidum. The water-insoluble rome (EXO-WI) showed the highest antitumor activity(92.1% inhibition rate) in carcoma- bearing mice, whereas, have relatively little activites at anticomplementary activity. In examination of macrophage activation, Raw 264.7 cells activated with EXO-WI incrased 3.5-fold(24 hrs) formation of nitric oxide levels and about 4-folds production of TNF – a compared with a control with medium only. EXO-WI was composed with exclusively b-D-glucose and 14.7% protein moiety. These results indicate that the EXO-WI purified from myelia of G. lucidum may be of a useful immunopotentiator in the treatment of cancer and immune disease.