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( Jung Bok Lee ),( Sung Min Jeong ),( Kyoung Jun Kim ),( Dong Hyun Cho ),( Il Keun Kwon ),( In Chan Yoon ),( Kui Won Choi ),( Jun Kyo Francis Suh ),( Jae Hong Park ),( Yong Duk Park ),( Jong Hyuk Chun 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
Dexamethasone(DEX), a synthetic steroidal anti-inflammatory drug, is an efficient and dependable drug that induces osteogenic differentiation. The aim of this study is to fabricate the DEX loaded PLGA nanofibers by electrospinning method. Adipose-derived stem cells(ADSCs) were seeded into the nanofiber and the sustained release of DEX from PLGA nanofiber scaffolds promoted their osteogenic differentiation. The properties of DEX loaded PLGA nanofiber scaffold were characterized by scanning electron microscopy(SEM) and the release kinetics of DEX from PLGA nanofibers in vitro(1 h to 14 days) was evaluated by high performed liquid chromatography(HPLC). To evaluate the cellular response of the ADSCs seeded onto DEX loaded PLGA nanofiber, we performed F-actin, cytotoxicity, alkaline phosphatase activity, alizarin red S, von Kossa staining and immunocytochemistry assays for osteogenic differentiation. DEX loaded PLGA nanofiber scaffold was observed to have sustained release in vitro during experimental periods. The cytotoxicity test of the DEX loaded PLGA nanofiber scaffold indicated there was almost no-toxic effects in regards to proliferation and differentiation of adiposederived stem cells(ADSCs) as compared with a control. Alkaline phosphatase activity and alizarin red S were more significantly increased after 14days with increased DEX concentration of PLGA nanofiber scaffold than with PLGA nanofiber only. Also, von Kossa staining results confirmed a larger area of calcium deposition with increased DEX concentration of PLGA nanofiber scaffold. We observed that osteocalcin was also increased with increasing DEX concentration. These results demonstrate that DEX acts as an osteogenic inductive factor, and increased DEX concentration promoted more osteogenic differentiation of ADSCs. In conclusion, DEX loaded PLGA nanofiber would be valuable tool for bone tissue regeneration.
장애인 정보격차 해소를 위한 정보통신 보조기기 활용방안 연구
김정호 ( Jung Ho Kim ),서준교 ( Jun Kyo Francis Suh ),구교준 ( Jun Koo ) 한국감성과학회 2010 감성과학 Vol.13 No.3
본 연구의 목적은 정보취약계층인 장애인의 정보화 수준 및 정보격차 현황의 파악·분석과 정보통신기기 수요조사를 통해, 장애인의 정보격차해소를 위한 정책방향 제시와 정보통신 보조기기의 개발 및 활용방안 마련을 위한 기초자료를 제공하는 것이다. 장애인의 정보격차 실태 및 현황 파악을 위해서, 장애여부에 따라 정보통신 기기 보유 및 접근성, 사용능력(역량), 활용도에 차이가 있는지를 T검정을 통해 분석하였다. 그 결과 장애여부에 따라 정보통신 기기 보유 및 접근성에 유의한 차이가 나타났다(T=-2.510*). 본 연구의 수요조사 결과, 정보통신 보조기기는 전체 응답자 중 약 28% 정도가 현재 사용하고 있는 것으로 분석되었으며, 다수의 응답자들이 보조기기의 사용이 실생활에 많은 도움을 준다고 답하였다(67%). 정부나 관련기관으로부터 정보통신 보조기기를 지원받은 경험이 있는 경우는 전체 응답자 중 36%로 나타났으며, 기기의 성능 측면에서도 대체로 만족스러웠다는 의견이 전체의 응답의 약 46%로 나타났다. 한편 기능조작 및 사용법 측면에서는 쉽고 편리다고 응답한 경우가 사용 경험자 전체의 36%에 불과했는데, 가장 큰 불편사항으로는 보조기기 조작의 어려움이라고 응답하였다. 이밖에 정보통신 보조기에 대한 전반적인 요구사항은 기기 성능의 안정화, 크기의 소형화, 버튼의 간소화, 무게의 경량화 등이었다. 본 연구는 장애인을 대상으로 심층면접을 통해 정보통신 보조기기의 이용 실태 및 수요를 구체적으로 밝힌 연구라는 점에서 의의가 있으며, 정보화기기 이용 시 보조기기가 필요한 장애인을 위한 보급정책 수립과 선정 기준을 마련하는 데에도 활용됨으로써 정책 실효성 제고에 크게 기여할 것으로 판단된다. The purposes of this study are to investigate and analyze the level of information and the state of digital divide of the disabled by surveying the demand for information and communication assistive devices, and to provide basic data for plans on the development and utilization of information and communication assistive devices. In order to understand the actual condition and the state of digital divide of persons with disabilities, the differences of possession and accessibility of information technology devices, usage ability, and utilization were analyzed according to the disability profile by using the T-test. The results show that there are significant differences (T=-2.510*) of possession and accessibility of information technology devices with respect to the disability profile, and that the disabled have lower possession and accessibility of devices than the non-disabled. Result of this study`s demand forecast shows that about 28% of total respondents are currently using information and communication assistive devices, and a majority (67%) of them answered that the use of assistive devices lend great help to their lives. The proportion of those who have been supported by the government or related organizations with information and communication assistive devices were 36% of the total respondents, and those satisfied with the performance of the devices were 46% of the total responses. Meanwhile, only 36% of total users answered that the operation and use of functions of the devices was easy and convenient, responding that the difficulty of operating assistive devices was the greatest inconvenience. Moreover, the general requests of respondents in regards to the devices were stabilization of device performance, miniaturization of size, simplification of buttons, and reduction of weight.
Jo, Sung-Eun,Joung, Sanghoon,Suh, Jun-Kyo Francis,Kim, Yong-Jun P. Peregrinus Ltd.] 2012 Medical & biological engineering & computing Vol.50 No.9
<P>Induction coils were fabricated based on flexible printed circuit board for inductive transcutaneous power transmission. The coil had closed magnetic circuit (CMC) structure consisting of inner and outer magnetic core. The power transmission efficiency of the fabricated device was measured in the air and in vivo condition. It was confirmed that the CMC coil had higher transmission efficiency than typical air-core coil. The power transmission efficiency during a misalignment between primary coil and implanted secondary coil was also evaluated. The decrease of mutual inductance between the two coils caused by the misalignment led to a low efficiency of the inductive link. Therefore, it is important to properly align the primary coil and implanted secondary coil for effective power transmission. To align the coils, a feedback coil was proposed. This was integrated on the backside of the primary coil and enabled the detection of a misalignment of the primary and secondary coils. As a result of using the feedback coil, the primary and secondary coils could be aligned without knowledge of the position of the implanted secondary coil.</P>
송강일,추준욱,서준교,최귀원,유선국,윤인찬,Song, Kang-Il,Chu, Jun-Uk,Suh, Jun-Kyo Francis,Choi, Kui-Won,Yoo, Sun-K.,Youn, In-Chan 대한의용생체공학회 2011 의공학회지 Vol.32 No.1
Cuff electrodes have a benefit for chronic electroneurogram(ENG) recording while minimizing nerve damage. However, the ENG signals are usually contaminated by electromyogram(EMG) activity from the surrounding muscle, the thermal noise generated within the source resistance, and the electric noise generated primarily at the first stage of the amplifier. This paper proposes a new cuff electrode to reduce the interference of EMG signals. An additional middle electrode was placed at the center of cuff electrode. As a result, the proposed cuff electrode achieved a higher signal-to-interference ratio compared to the conventional tripolar cuff. The cuff electrode was then assembled together with closure, headstage, and hermetic case including electronic circuits. This paper also presents a lownoise amplifier system to improve signal-to-noise ratio. The circuit was designed based on the noise analysis to minimize the electronic noise. The result shows that the total noise of the amplifier was below $1{\mu}V_{rms}$ for a cuff impedance of $1\;k{\Omega}$ and the common-mode rejection ratio was 115 dB at 1 kHz. In the current study, the performance of nerve cuff electrode system was evaluated by monitoring afferent nerve signals under mechanical stimuli in a rat animal model.
Shin, Eun Sil,Hwang, Onyou,Hwang, Yu-Shik,Suh, Jun-Kyo Francis,Chun, Young Il,Jeon, Sang Ryong The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.56 No.5
Objective : Neural tissue transplantation has been a promising strategy for the treatment of Parkinson's disease (PD). However, transplantation has the disadvantages of low-cell survival and/or development of dyskinesia. Transplantation of cell aggregates has the potential to overcome these problems, because the cells can extend their axons into the host brain and establish synaptic connections with host neurons. In this present study, aggregates of human brain-derived neural stem cells (HB-NSC) were transplanted into a PD animal model and compared to previous report on transplantation of single-cell suspensions. Methods : Rats received an injection of 6-OHDA into the right medial forebrain bundle to generate the PD model and followed by injections of PBS only, or HB-NSC aggregates in PBS into the ipsilateral striatum. Behavioral tests, multitracer (2-deoxy-2-[$^{18}F$]-fluoro-D-glucose ([$^{18}F$]-FDG) and [$^{18}F$]-N-(3-fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl)nortropane ([$^{18}F$]-FP-CIT) microPET scans, as well as immunohistochemical (IHC) and immunofluorescent (IF) staining were conducted to evaluate the results. Results : The stepping test showed significant improvement of contralateral forelimb control in the HB-NSC group from 6-10 weeks compared to the control group (p<0.05). [$^{18}F$]-FP-CIT microPET at 10 weeks posttransplantation demonstrated a significant increase in uptake in the HB-NSC group compared to pretransplantation (p<0.05). In IHC and IF staining, tyrosine hydroxylase and human ${\beta}2$ microglobulin (a human cell marker) positive cells were visualized at the transplant site. Conclusion : These results suggest that the HB-NSC aggregates can survive in the striatum and exert therapeutic effects in a PD model by secreting dopamine.