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유통 축·수산물 중 잔류벤질페니실린의 검출 및 모니터링
이효정(Hyo Jeong Lee),강영원(Young Won Kang),이수민(Soo Min Lee),안경아(Kyung A An),이륜경(Ryun Kyung Lee),서상철(Sang Cheol Seo),이주희(Ju Hee Lee),임무혁(Moo Hyeog Im),이정림(Jeong Rim Lee),홍충만(Choong Man Hong),장문익(Moon Ik Ch 한국식품과학회 2014 한국식품과학회지 Vol.46 No.3
국내 유통 중인 돼지고기, 소고기, 닭고기, 넙치 232건의 시료에 대해 벤질페니실린의 잔류량을 조사하기 위해 현행 식품공전 상 축·수산물 중 벤질페니실린 분석법에 대한 검증을 실시하고 모니터링을 수행하였다. 그 결과 벤질페니실린에 대한 분석법은 CODEX에서 요구하는 기준에 적합한 정밀성과 정확성을 보였다. 벤질페니실린의 잔류량 모니터링 결과 축산물 193건 중 11건, 수산물 39건 중 2건 총 13건이 검출되었다. 검출된 수준은 축·수산물 12건에서 0.001-0.004 mg/kg으로 잔류허용기준 이하로 검출되었으나, 축산물 중 국내산 돼지고기 1건에서 잔류허용기준을 초과한 0.134 mg/kg 수준으로 검출되어 해당 유관기관에 부적합 통보 및 사후관리를 요청하였다. 따라서 벤질페니실린 등 항생제는 다른 동물용 의약품에 비해 사용빈도가 많은 만큼 지속적으로 잔류모니터링과 관리가 필요할 것으로 판단된다. Penicillin and its salts, including the benzatine, procaine, and sodium salts, have been widely used in human and veterinary medicine. Owing to their low toxicity, they currently form the most important group of antibiotics. However, overdose and abuse of these antibiotics may lead to potential risk in human health. Therefore, this study was conducted to validate the analysis method established by the Korea Food Code in 2012 and to monitor the levels of benzylpenicillin residues in products with reference to the maximum residue level (MRL). Of the 232 product samples tested, benzylpenicillin was detected in 11 livestock products and 2 marine products. Benzylpenicillin concentrations were found to be lower than the MRL in 12 products; however, the concentration of benzylpenicillin was found to be greater than the MRL in 1 pork product. The limit of quantification (LOQ) for benzylpenicillin was found to be 0.001-0.002 mg/kg, with an average recovery of 90.4-115.3%. Calibrations showed good linearity of 0.995 over a range of 0.002-0.05 mg/kg.
GO-02 : Risk factors for vaginal vault dehiscence after total laparoscopic hysterectomy
( Hyo Ryun Lee ),( In Ok Lee ),( Dawn Jung ),( Won Yim ),( Sang Wun Kim ),( Sung Hoon Kim ),( Young Tae Kim ),( Jae Wook Kim ),( Eun Ji Nam ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
To determine patients risk factors and compare sutures for vaginal vault dehiscence (VVD) after laparoscopic hysterectomy A retrospective analysis was performed with 1059 patients who underwent laparoscopic hysterectomy between March 2011 and May 2013. The following parameters were analyzed using independent t-test and logistic regression analysis (SPSS version 18.0 ; IBM, New York, USA) : suture approach method, continuity of suture, age, BMI, parity, blood loss, uterus weight, and total operating time. The study group was composed of 932 (88%) patients who were sutured by laparoscopic sutures and 127 (12%) patients who were sutured by transvaginal sutures. 9 patients (0.8%) out of total 1059 patients had VVD after laparoscopic hysterectomy. Although statistically not significant, this study revealed that the patients with VVD had a tendency to have greater age, total operating time, blood loss, parity and had less uterus weight. Low BMI had a statistically significant difference in VVD (p-value = 0.016). VVDs were occurred in continuous suture rather than interrupted suture without statistical significance, and also more often in transvaginal sutures for vaginal vault closure than laparoscopic sutures with statistical significance. (OR = 6.029, 1.598-22.755, P-value = 0.008) Laparoscopic sutures is associated with fewer instances of vaginal vault dehiscence than transvaginal sutures after total laparoscopic hysterectomy.
( Hyo Ryun Lee ),( Ju Hyun Cho ),( Ha Yan Kwon ),( Ja Young Kwon ),( Young Han Kim ),( Yong Won Park ),( Hee Young Cho ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: The aim of this study was to determine the factors associated with pelvic artery embolization (PAE) failure used for the management of postpartum hemorrhage(PPH). 방법: From February 2005 to April 2014, a retrospective analysis of 291 patients undergoing PAE for PPH was performed. Clinical data, including maternal characteristics, delivery details, and transfusion requirements were obtained. We compared embolization success and failure group to investigate the factors associated with failure of embolization. 결과: : The study groups were composed of 87 (29.9%) women with embolization failure group (FG) and 204 (70.1%) women with embolization success group (SG). The major cause of bleeding in the FG and SG was uterine atony (51.8%; 43/87 vs 64.0%; 130/204). The proportion of placenta previa was more frequent in the FG than the SG (22%; 19/86 vs 11%; 22/202, p-value = 0.013) Patient who was refered from other hospital tend to embolization failure for PPH. In preoperative laboratory results, the levels of Hb and Hct were significantly lower in the FG (8.9 ± 2.0 vs 9.7± 2.2, p-value = 0.003, 26.1 ± 6.0 vs 28.3 ± 6.2, p-value = 0.006). In the FG, the most common additional management was re-embolization (n=50, 57.5%), followed by hysterectomy (n=20, 23.0%), bleeder ligation at operation room (n=10, 11.5%), MTX injection (n=5, 5.7%) and dilatation & curettage (n=2, 2.3%). There was no statistically significant difference in the maternal age, parity and history of transfusion at the previous hospital between the FG and the SG. After PAE, mean length of hospital stay (8.3 ± 11.3 vs 5.8 ± 4.5, p-value = 0.006) the rate of admission to an intensive care unit (49.4%; 43/44 vs 26.1%; 53/150, p-value < 0.001) were higher in the FG. 결론: Our study suggested that patient who was refered from other hospital, placenta previa, lower levels of preoperative Hb and Hct were factors related with pelvic artery embolization failure for postpartum hemorrhage.
IEEE 802.15.4 메쉬 센서 네트워크에서의 경쟁 및 충돌 완화 기법
이효련(Hyo Ryun Lee),정경학(Kyoung-Hak Jung),서영주(Young-Joo Suh) 한국통신학회 2013 韓國通信學會論文誌 Vol.38 No.8(융합기술)
본 논문은 IEEE 802.15.4 기반 메쉬 센서 네트워크 환경에서 인접 코디네이터 간 발생할 수 있는 패킷 충돌문제를 완화하는 기법을 다룬다. 기존 연구에서는 센서 노드의 backoff period (BP)를 적절하게 조절하여 재전송 횟수를 줄이거나, 트래픽 부하에 따라 채널 활용도롤 효율적으로 높임으로써 불필요한 에너지 소모를 줄이고자 하였다. 기존 연구와 달리 제안 기법에서는 인접 코디네이터 사이의 경쟁을 회피하여 센서 노드의 에너지 효율성을 향상시키고자 한다. 이를 위해 제안하는 기법에서는 인접 코디네이터들의 경쟁 구간 시작 시점을 분산시켜 코디네이터 간에 발생하는 경쟁 및 패킷 충돌을 완화하였다. 시뮬레이션을 이용한 성능 평가를 통해 제안하는 기법이 에너지 소모 측면에서 보다 효율적일 뿐만 아니라 충돌 발생 정도, throughput, 전송 지연 등 다양한 측면에서 그 성능이 향상됨을 확인할 수 있었다. This paper address a new scheme that alleviates the packet collision problem caused by contentions among nearby coordinators (CNs) in IEEE 802.15.4 meshed sensor networks. In existing studies, the number of retransmissions is reduced by adjusting the proper backoff period (BP) of sensor nodes, or unnecessary energy consumption is diminished by increasing channel utilization efficiently based on traffic load. In contrast, the proposed scheme avoids contentions among nearby CNs, thereby it enhances the energy efficiency of sensor nodes. To achieve this, the proposed scheme separates the starting points of CNs‘ contention periods and reduces contentions and collisions among overlapping CNs. According to our simulation results, the proposed scheme shows improved performance in terms of energy consumption, throughput, the number of collisions, and average delay for all conditions.
불안정 지지면에서의 유산소 운동이 심폐기능과 균형능력에 미치는 영향
권효륜(Hyo-Ryun Kwon),김미소(Mi-So Kim),남유정(Yu-Jung Nam),박혜민(Hye-Min Park),이경선(Kyeong-Sun Lee),조홍덕(Hong-Deok Jo),최동원(Dong-Won Choi),양회송(Heo-Song Yang),유영대(Young-Dae Yoo),강효정(Hyo-jeong Kang),정찬주(Chan-Joo Jeo 대한심장호흡물리치료학회 2018 대한심장호흡물리치료학회지 Vol.6 No.1
The purpose of this study was to investigate the effects of aerobic exercise with unstable supporting surface on cardio-pulmonary function and balance ability. Methods : This study was performed on 20 subjects. The subjects were divided into two groups; stable supporting surface group(Group Ⅰ, n=10), unstable supporting surface group(Group Ⅱ, n=10). The groups performed the aerobic exercise, which is jump rope exercise, 2 times a week for 4 weeks. Results : The results were as follows. There was statistically significant difference of cardiovascular endurance in Group Ⅰ(p<0.05), and there were statistically significant difference of cardiovascular endurancedynamic, OSI and dynamic APSI in Group Ⅱ (p<0.05). However, there were no statistically significant difference in pulmonary functions which were FVC and FEV1 in Group Ⅰand Group Ⅱ. Conclusion : As a result of this study, aerobic exercise with unstable supporting surface have a potential to induce positive responses in cardiovascular endurance and dynamic balance ability of healthy adults.
염산부플로메딜 정과 염산티클로피딘 정의 용출시험법 개발
이륜경(Ryun-Kyung Lee),정경록(Gyeong-Rok Jeong),오현숙(Hyun-Sook Oh),심지연(Jee-Youn Shim),서상철(Sang-Chul Suh),이효정(Hyo-Jung Lee),김민아(Min-A Kim),박성민(Seong-Min Park),이규하(Kyu-Ha Lee),손경희(Kyung-Hee Sohn),김인규(In-Kyu Ki 대한약학회 2012 약학회지 Vol.56 No.4
Drug dissolution test has been used for the purpose of both quality control of solid oral dosage forms and predicting in vivo drug release profiles. In this study, the dissolution profiles of buflomedil hydrochloride tablets and ticlopidine hydrochloride tablets were investigated according to the “Guidelines on Specifications of Dissolution tests for Oral dosage forms” of Korean Pharmacopoeia (KP). The analytical method using HPLC was validated. The validation was performed in terms of specificity, linearity, accuracy, precision and limit of quantitation.
이효정(Hyo Jung Lee),심지연(Jee Youn Shim),오현숙(Hyun Suk Oh),장미란(Mi Ran Jang),이윤애(Yoon Ae Lee),이륜경(Ryun Kyung Lee),김민아(Min-A Kim),이상민(Sang Min Lee),조태용(Tae Yong Cho),강호일(Ho Il Kang) 한국식품과학회 2012 한국식품과학회지 Vol.44 No.1
본 연구에서는 주요섭취 가공식품(우유, 식용유지, 마가린) 3개 품목에 대한 납, 카드뮴, 비소의 기준ㆍ규격 설정을 위해 가공식품 총 287건을 전국 8개 권역(강원, 경기, 경남, 경북, 충청, 전남, 전북, 경남, 제주)에서 수거하고 각 시료를 microwave 분해법으로 전처리 하였다. 시료의 산분해 전처리 시 보다 객관화된 시료 전처리 방법의 확립을 위해 잔여 <SUP>12</SUP>C intensity를 ICP-MS로 측정하여 가장 분해정도가 우수한 조건(검체량, 질산량, 과산화수소량)을 선정하였다. 최적조건에서 전처리한 시료의 납, 카드뮴, 비소 함량은 ICP-MS로 분석하였다. 정량한계(Limit of quantification, LOQ)는 납의 경우, 우유 0.3 μg/kg, 식용유지, 마가린 0.61 μg/kg이었고, 카드뮴의 경우, 우유 0.15 μg/kg, 식용유지, 마가린 0.31 μg/kg이었다. 비소의 경우, 우유 0.45 μg/kg, 식용유지, 마가린 0.91 μg/kg이었다. 납, 카드뮴, 비소의 회수율은 납 92.6-98.0%, 카드뮴 91.2-98.9%, 비소 97.9-105.6% 수준 이었다 모니터링 결과, 가공식품의 납의 평균함량은 우유 2.395 μg/kg, 식용유지 7.656 μg/kg이었으며, 카드뮴의 평균함량은 우유 0.483 μg/kg, 식용유지 0.380 μg/kg이었다. 비소의 평균함량은 우유 0.781 μg/kg, 식용유지 1.241 μg/kg이었다. 가공식품의 Codex 납 기준 0.02-0.1 mg/kg, 카드뮴 0.1 mg/kg, 비소 0.1 mg/kg 수준과 비교해 볼 때, 모든 검체에서 기준보다 낮은 수준이었다. 2005년 국민건강조사 DB에서 조사대상 인구집단 전체를 대상으로 위해평가 한 결과 대상 식품들의 납, 카드뮴, 비소의 인체노출수준을 JECFA의 납, 카드뮴, 비소의 잠정주간섭취허용량으로 나누어 위해지수를 산출한 결과, 1.0 보다 훨씬 낮게 나타남으로 위해도는 매우 낮은 수준으로 판단된다. This research was carried out as a survey on the contents of lead, cadmium, and arsenic in processed foods (milk, vegetable oil, and margarine) in Korea. The limits of quantification (LOQs) were Pb 0.3 μg/kg, Cd 0.15 μg/kg, and As 0.45 μg/kg for milk and Pb 0.61 μg/kg, Cd 0.31 μg/kg, and As 0.91 μg/kg for vegetable oil and margarine. The recoveries were 92.6-98.0% for Pb, 91.2-98.9% for Cd, and 97.9-104.7% for As. The average levels of Pb were 2.395 μg/kg for milk, and 7.656 μg/kg for vegetable oil. The average levels of Cd were 0.483 μg/kg for milk, and 0.380 μg/kg for vegetable oil, and levels of As were 0.781 μg/kg for milk, and 1.241 μg/kg for vegetable oil. The results of this study showed that Pb, Cd, and As contents in the whole samples were less than the maximum residual levels in the processed foods that were specified by the Codex standard.