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A Survey of Liver Cancer Specialists’ Views on the National Liver Cancer Screening Program in Korea
( Won Sohn ),( Young-sun Lee ),( Jae Geun Lee ),( Jihyun An ),( Eun Sun Jang ),( Dong Ho Lee ),( Dong Hyun Sinn ) 대한간암학회 2020 대한간암학회지 Vol.20 No.1
Background/Aims: To reduce the cancer burden, the Korean government initiated the National Cancer Control Plan including the National Liver Cancer Screening Program (NLCSP). Ultrasonography examinations and α-fetoprotein tests at six-month intervals are currently offered for high-risk individuals. High-risk individuals are identified by reviewing the National Health Insurance Service claims data for medical use for the past two years using International Classification of Diseases Codes for specific liver disease. We surveyed the attitudes and opinions towards the NLCSP to understand the issues surrounding the NLCSP in Korea. Methods: Altogether, 90 Korean Liver Cancer Association members participated in online and offline surveys between November and December 2019. Results: Approximately one-quarter (27%) of the survey participants rated the NLCSP as very contributing and about two-thirds (68%) as contributing to some extent toward reducing hepatocellular carcinoma (HCC)-related deaths in Korea. Most (87.8%) responded that the current process of identifying high-risk individuals needs improvement. Many (78.9%) were concerned that the current process identifies individuals who use medical services and paradoxically misses those who do not. When asked for the foremost priority for improvement, solving ‘duplication issues between the NLCSP and private clinic HCC screening practices’ was the most commonly selected choice (23.3%). Conclusions: The survey participants positively rated the role of the NLCSP in reducing liver cancer deaths. However, many participants rated the NCLSP as needing improvement in all areas. This survey can be a relevant resource for future health policy decisions regarding the NLCSP in Korea. (J Liver Cancer 2020;20:53-59)
A Clinical Study on Dyspneic Patients Admitted through Emergency Room
Won Tae Chung,Gye Ik Sohn,Jang Geun Park,Soon Kew Park,Young Kee Shin Korean Society of Critical Care Medicine 1987 Acute and Critical Care Vol.2 No.1
Authors obtained the following results through the clinical study on 129 cases of dyspneic patients, admitted through the Emergency Room of Pusan National University Hospital from January 1984 to June 1985. 1) The study group was 129 patients with dyspnea, male 81 caaes(62.8%) and female 48 cases(37.2%). Male to female ratio was 1.7:l. 2) Underlying diseases were pulmonary diseases in 61 cases(47,3%), cardiovascular diseases in 56 cases(43.4%). 3) The most frequently associated symptoms with dyspnea were coughing in pulmonary diseases and chest pain in cardiovascular diseases. 4) Respiratory rate was much more markedly increased in cardiovascular diseases than in pulmonary diseases. 5) Abnormal breathing sound was noted in 85 eases(65.9%), and arrythmia and cardiac murmur were noted in 8 cases(6.2%) at auscultation. 6) Mental status was alert in most of the cases(80.6%). 7) Pulmonary function test revealed the more marked impairment in pulmonary diseases, and there were more significant differences in FEV and FEF25 ~75%.
Jang, In-Seok,La, Jun-Ho,Kim, Gyu-Tae,Lee, Jeong-Soon,Kim, Eun-Jin,Lee, Eun-Shin,Kim, Su-Jeong,Seo, Jeong-Min,Ahn, Sang-Ho,Park, Jae-Yong,Hong, Seong-Geun,Kang, Da-Won,Han, Jae-Hee The Korean Society of Pharmacology 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.5
Single-channel recordings of TASK-1 and TASK-3, members of two-pore domain $K^+$ channel family, have not yet been reported in dorsal root ganglion (DRG) neurons, even though their mRNA and activity in whole-cell currents have been detected in these neurons. Here, we report single-channel kinetics of the TASK-3-like $K^+$ channel in DRG neurons and up-regulation of TASK-3 mRNA expression in tissues isolated from animals with spinal cord injury (SCI). In DRG neurons, the single-channel conductance of TASK-3-like $K^+$ channel was $33.0{\pm}0.1$ pS at - 60 mV, and TASK-3 activity fell by $65{\pm}5%$ when the extracellular pH was changed from 7.3 to 6.3, indicating that the DRG $K^+$ channel is similar to cloned TASK-3 channel. TASK-3 mRNA and protein levels in brain, spinal cord, and DRG were significantly higher in injured animals than in sham-operated ones. These results indicate that TASK-3 channels are expressed and functional in DRG neurons and the expression level is up-regulated following SCI, and suggest that TASK-3 channel could act as a potential background $K^+$ channel under SCI-induced acidic condition.
Jang, In-Seok,Jeon, Byeong-Tak,Jeong, Eun-Ae,Kim, Eun-Jin,Kang, Da-Won,Lee, Jong-Sil,Jeong, Baek-Geun,Kim, Jin-Hyun,Choi, Bong-Hoi,Lee, Jung-Eun,Kim, Jong-Woo,Choi, Jun-Young,Roh, Gu-Seob The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.3
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small cell lung carcinoma (NSCLC). Although both SCCs and ACs have been characterized histologically and clinically, the precise mechanisms underlying their migration and invasion are not yet known. Here, we address the involvement in NSCLC of the p21-associated kinase1 (Pak1)/LIM kinase1 (LIMK1)/cofilin pathway, which recently has been reported to play a critical role in tumor migration and invasion. The Pak1/LIMK1/cofilin pathway was evaluated in tumors from SCC (n=35) and AC (n=35) patients and in SCC- and AC-type cell lines by western blotting, immunohistochemistry, and in vitro migration and invasion assays. The levels of phosphorylated Pak1, LIMK1, and cofilin in lung tumor tissues from SCC patients were increased as compared to normal tissues. In addition, immunohistochemistry showed greater expression of phosphorylated cofilin in SCC tissues. Expression of phosphorylated Pak1 and LIMK1 proteins was also significantly higher in SCC-type cells than in AC-type cells. Moreover, migration and invasion assays revealed that a higher percentage of SCC type cells exhibited migration and invasion compared to AC type cells. Migration was also decreased in LIMK1 knockdown SK-MES-1 cells. These findings suggest that the activation of the Pak1/LIMK1/cofilin pathway could preferentially contribute to greater tumor migration and invasion in SCC, relative to that in AC.
Jang, Yong Hyun,Hong, Nam-Soo,Moon, Sun Young,Eun, Dong Hyuk,Lee, Won Kee,Chi, Seong Geun,Kim, Jun Young,Lee, Weon Ju,Lee, Seok-Jong,Kim, Do Won S. Karger AG 2017 Dermatology Vol.233 No.2
<P>Background: In alopecia totalis (AT) and alopecia universalis (AU), the chance of full hair regrowth is known to be less than 10%. However, this information is based on a few older studies conducted in the 1950s and 1960s. Objective: We investigated the current long-term prognosis of individuals with AT/AU. Methods: A retrospective chart review was performed in patients with AT/AU between 1994 and 2005. Outcome data were collected by reviewing outpatient clinical files or by phone interviews. Finally, the long-term assessment of 70 patients with valid outcome data was performed. Results: Twelve out of 70 patients with AT/AU (17.1%) had complete hair regrowth. Five out of 24 patients with AT (20.8%) showed complete hair regrowth, and 7 of 46 patients with AU (15.2%) achieved complete regrowth. Seventeen out of 70 patients with AT/AU (24.2%) reported hair regrowth greater than or equal to 90%. Thirty patients with AU (65.2%) remained in an alopecic state without improvement, while 5 patients with AT (20.8%) showed no hair regrowth. Conclusion: Our results suggest that the long-term prognosis of AT/AU is more favorable than previously thought. However, the clinical burden of AT/AU is still substantial. (C) 2017 S. Karger AG, Basel</P>
Cesium Release Behavior during the Themal Treatment of High Burn-up Spent PWR Fuel
Geun IL Park,Kwang Hun Cho,Jung Won Lee,Jang Jin Park,Myung Seung Yang,Kee Chan Song 한국방사성폐기물학회 2007 방사성폐기물학회지 Vol.5 No.1
고연소도 경수로사용후핵연료를 이용하여 voloxidation 및 소결 열처리 공정으로부터 세슘의 시간에 따른 방출 거동을 실험적으로 평가하였다. 사용후핵연료 voloxidation 공정에서는 fragment 형태의 시편을 사용하여 최대 의 산화 및 환원 분위기에 따른 세슘 방출 거동을 상호 비교하였으며, 소결 공정에서는 압분체를 이용하여 4% H2/Ar 환원분위기 에서 열처리 온도 변화에 따른 세슘방출 특성 변화를 분석하였다. 산화 분위기에서 fragment 형태의 사용후핵연료로부터 세슘 방출 온도 구간은 였으며, 환원 분위기에서 압분체로부터 방출 온도 구간은 로서, 산화에 의한 사용후핵 연료의 분말화가 세슘 방출 거동에 영향을 미치는 것으로 나타났다. 아울러 사용후핵 연료로부터 세슘 방출 거동에 영향을 미치는 주요 인자는 사용후핵 연료내 세슘 화합물의 화학적 형태뿐만 아니라 결정립 및 핵연료 표면으로의 확산 속도에 지배를 받음을 알 수 있었다. The dynamic release behavior of Cs from high burn-up spent PWR fuel was experimentally performed under the conditions of a thermal treatment process such as voloxidation and sintering conditions. In voloxidation process, influence of the oxidation and reduction atmosphere on the Cs release characteristic using fragment type of spent fuel heated up to was compared. In sintering process, temperature history effect on Cs release behavior was evaluated using green pellet under 4% environment. Temperature range for complete Cs release from spent fuel fragment under voloxidation condition was about , but that of green pellet under the reduction atmosphere was . Key parameters on Cs release behavior from spent fuel was powder formation as well as the diffusion rate of Cs compound to grain boundary and fuel surface.