Steam-Chest Molding of Expanded Polypropylene Foams. 2. Mechanism of Interbead Bonding

Zhai, Wentao,Kim, Young-Wook,Jung, Dong Won,Park, Chul B. American Chemical Society 2011 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.50 No.9

<P>Expanded polypropylene (EPP) bead foams were processed using steam-chest molding. Interbead bonds formed during processing and was characterized by observing both the product surface and the fracture surfaces using scanning electron microscopy (SEM) and by measuring the tensile properties of specimens. It was found that both the degree of interbead bonding and the tensile strength had a direct relationship to the steam pressure/temperature and that high steam temperature enhanced the crystallization behavior of EPP beads during the cooling process. A formation mechanism of interbead bonding during processing was proposed based on the crystal melting behaviors, as discussed in the first article of this series (<name name-style='western'>Zhai</name> et al. Ind. Eng. Chem. Res.<x xml:space='preserve'> </x>2010<x xml:space='preserve'>, </x>49<x xml:space='preserve'>, </x>9822). Possible parameters influencing the formation of interbead bonding, namely, steam temperature/pressure and bead foam expansion ratio, were investigated in this study. The effect of postannealing of the EPP products on the shrinkage and crystallinity of the molded EPP products was also addressed.</P>

Study on the Effects of Electrodes of EAPap into Vibration Energy Harvesting

Lin Dong Zhai(적림동),Zafar Abas(자파아바스),Heung Soo Kim(김흥수),Joo-Hyong Kim(김주형),Jaehwan Kim(김재환) 한국소음진동공학회 2012 한국소음진동공학회 학술대회논문집 Vol.2012 No.4

Overexpression of Phospholipase A₂ Group IIA in Esophageal Squamous Cell Carcinoma and Association with Cyclooxygenase-2 Expression

Zhai, Yan-Chun,Dong, Bin,Wei, Wen-Qiang,He, Yan,Li, Xin-Qing,Cormier, Robert T.,Wang, Wei,Liu, Fen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Background: Esophageal cancer is one of the most frequently occurring malignancies and the seventh leading cause of cancer-related deaths in the world. The esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer worldwide. Materials and Methods: Our goal in this study was to detect phospholipase A2 Group IIA (PLA2G2A) and cyclooxygenase-2 (COX-2) immuno-expression in ESCC in a high-risk population in China. Results: Positive expression of PLA2G2A protein was observed in 57.2% (166/290) of the cases, while COX-2 was found in 257 of 290 samples (88.6%), both PLA2G2A and COX-2 being expressed in 153 cases (52.8%), with a significant agreement (Kappa=0.091, p=0.031).Overexpression of PLA2G2A was significantly correlated with the depth of invasion (p=0.001). Co-expression of PLA2G2A and COX-2 not only significantly correlated with the depth of invasion (p=0.004) but also with TNM stage (p=0.04). Conclusions: Our results showed that in patients with ESCC, PLA2G2A overexpression and PLA2G2A co-expression with COX-2 is significantly correlated with advanced stage. The biological role and pathophysiologic regulation of PLA2G2A and COX-2 overexpression in ESCC deserve further investigation.

MPC-based Two-stage Rolling Power Dispatch Approach for Wind-integrated Power System

Zhai, Junyi,Zhou, Ming,Dong, Shengxiao,Li, Gengyin,Ren, Jianwen The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.2

Regarding the fact that wind power forecast accuracy is gradually improved as time is approaching, this paper proposes a two-stage rolling dispatch approach based on model predictive control (MPC), which contains an intra-day rolling optimal scheme and a real-time rolling base point tracing scheme. The scheduled output of the intra-day rolling scheme is set as the reference output, and the real-time rolling scheme is based on MPC which includes the leading rolling optimization and lagging feedback correction strategy. On the basis of the latest measured thermal unit output feedback, the closed-loop optimization is formed to correct the power deviation timely, making the unit output smoother, thus reducing the costs of power adjustment and promoting wind power accommodation. We adopt chance constraint to describe forecasts uncertainty. Then for reflecting the increasing prediction precision as well as the power dispatcher's rising expected satisfaction degree with reliable system operation, we set the confidence level of reserve constraints at different timescales as the incremental vector. The expectation of up/down reserve shortage is proposed to assess the adequacy of the upward/downward reserve. The studies executed on the modified IEEE RTS system demonstrate the effectiveness of the proposed approach.

Restricting Factors and Countermeasures of Development in Business Services Industry of Shandong Province

Dong Hua Lin,Wen Xiu Zhai 한국유통과학회 2013 KODISA ICBE (International Conference on Business Vol.2013 No.-

Firstly, this article expounds that business service industry plays an important role in adjusting industrial structure, transforming mode of economic growth, improving people's living standards, enhancing Enterprise's Kernel Competitiveness and promoting the development of service industry. Then it analyzes the development of business services in Shandong from two perspectives. The first perspective, by using methodology for statistical analysis, it will review the development scale, professional level, the number of opening units, quantity of employment, and operating revenue of business services in Shandong. On this basis, the article will summarize its development characteristics, experience and existing shortcomings. The second perspective, by using comparison analysis methodology, to compare the development of Shandong with Jiangsu, Guangdong, Zhejiang and Shanghai’s and found the subjective and objective factors that restrict the development of business service industry in Shandong. In the light of restricting factors, countermeasures have been developed based on the experience at home and abroad. These countermeasures will contribute to promoting the optimization and upgrading of industrial structure, improving industrial competitiveness and speeding up the economic development rapidly and stably.

MicroRNA-206 Protects against Myocardial Ischaemia-Reperfusion Injury in Rats by Targeting Gadd45β

Zhai, Changlin,Qian, Qang,Tang, Guanmin,Han, Bingjiang,Hu, Huilin,Yin, Dong,Pan, Haihua,Zhang, Song Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.12

MicroRNAs are widely involved in the pathogenesis of cardiovascular diseases through regulating gene expression via translational inhibition or degradation of their target mRNAs. Recent studies have indicated a critical role of microRNA-206 in myocardial ischaemia-reperfusion (I/R) injury. However, the function of miR-206 in myocardial I/R injury is currently unclear. The present study was aimed to identify the specific role of miR-206 in myocardial I/R injury and explore the underlying molecular mechanism. Our results revealed that the expression level of miR-206 was significantly decreased both in rat I/R group and H9c2 cells subjected to hypoxia/reoxygenation (H/R) compared with the corresponding control. Overexpression of miR-206 observably decreased infarct size and inhibited the cardiomyocyte apoptosis induced by I/R injury. Furthermore, bioinformatics analysis, luciferase activity and western blot assay proved that $Gadd45{\beta}$ (growth arrest DNA damage-inducible gene $45{\beta}$) was a direct target gene of miR-206. In addition, the expression of pro-apoptotic-related genes, such as p53, Bax and cleaved caspase3, was decreased in association with the down-regulation of $Gadd45{\beta}$. In summary, this study demonstrates that miR-206 could protect against myocardial I/R injury by targeting $Gadd45{\beta}$.

Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/ PKA/CREB signaling pathway in the trigeminal ganglion in rats

QingLing Zhai,KaiXin Wang,Defu Zhang,Jinbo Chen,XiaoMeng Dong,Yonghui Pan 대한통증학회 2023 The Korean Journal of Pain Vol.36 No.3

Background: Perampanel, a highly selective glutamate AMPA receptor antagonist, is widely used to treat epilepsy. Since the existence of common pathophysiological features between epilepsy and migraine, the aim of this study was to investigate whether perampanel could exert an antimigraine effect. Methods: Nitroglycerin (NTG) was used to induce a migraine model in rats, and the model animals were pretreatment with 50 μg/kg and 100 μg/kg perampanel. The expression of pituitary adenylate-cyclase-activating polypeptide (PACAP) was quantified by western blot and quantitative real-time PCR in the trigeminal ganglion, and rat-specific enzyme-linked immunosorbent assay in serum. Western blot was also conducted to explore the effects of perampanel treatment on the phospholipase C (PLC)/protein kinase C (PKC) and protein kinase A (PKA)/ cAMP-responsive-element-binding protein (CREB) signaling pathways. Moreover, the cAMP/PKA/CREB-dependent mechanism was evaluated via in vitro stimulation of hippocampal neurons. The cells were treated with perampanel, antagonists and agonists for 24 hours and cell lysates were prepared for western blot analysis. Results: Perampanel treatment notably increased the mechanical withdrawal threshold and decreased head grooming and light-aversive behaviors in NTG-treated rats. It also decreased PACAP expression and affected cAMP/ PKA/CREB signaling pathway. However, PLC/PKC signaling pathway may not be involved in this treatment. In in vitro studies, perampanel notably decreased PACAP expression by inhibiting cAMP/PKA/CREB signaling pathway. Conclusions: This study shows that perampanel inhibits the migraine-like pain response and that this beneficial effect might be attributable to regulation of the cAMP/PKA/CREB signaling pathway.

Numerical investigation on the wave interferences of submerged bodies operating near the free surface

Li Dong,Yang Qun,Zhai Lin,Wang Zhen,He Chuan-lin 대한조선학회 2021 International Journal of Naval Architecture and Oc Vol.13 No.1

A key factor that governs the wave interferences of a submerged body is the dimensionless Froude number. Computational Fluid Dynamics (CFD) is used to describe the resistance force coefficients and the generated waves of two SUBOFF submarine models. Grid independence studies are performed on two cases, totally and shallowly submerged cases, with four sets of computing meshes. The highest peaks are marked by red points at given wavelengths, a line is fitted to those points with a least-squares approximation, and the half wake angle at multiple Froude numbers is defined between the fitted line and the centerline of the free surface. The results show that when the depth of the target is 1.1D, constructive interferences occur at Fn ¼ 0.3 and 0.5, while destructive interference occurs at Fn ¼ 0.35 with distortion of the waveform. The half wake angle is less than 19.47 because of the interference between the bow and stern wave systems.

Phenolic constituents from Parakmeria yunnanensis and their anti-HIV-1 activity

Shan-Zhai Shang,Huan Chen,Cheng-Qin Liang,Zhong-Hua Gao,Xue Du,Rui-Rui Wang,Yi-Ming Shi,Yong-Tang Zheng,Wei-Lie Xiao,Han Dong Sun 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.10

Three new phenolic compounds, yunnanensinsA–C (1–3), together with fourteen known ones (4–17),were isolated from the leaves and stems of Parakmeriayunnanensis. The structures of new compounds wereestablished on the basis of extensive spectroscopic analyses. Several compounds showed weak anti-HIV-1 activity.

MicroRNA-206 Protects against Myocardial Ischaemia-Reperfusion Injury in Rats by Targeting Gadd45β

Changlin Zhai,Qang Qian,Guanmin Tang,Bingjiang Han,Huilin Hu,Dong Yin,Haihua Pan,Song Zhang 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.12

MicroRNAs are widely involved in the pathogenesis of cardiovascular diseases through regulating gene expression via translational inhibition or degradation of their target mRNAs. Recent studies have indicated a critical role of microRNA-206 in myocardial ischaemia-reperfusion (I/R) injury. However, the function of miR-206 in myocardial I/R injury is currently un-clear. The present study was aimed to identify the specific role of miR-206 in myocardial I/R injury and explore the underlying molecular mechanism. Our results revealed that the expres-sion level of miR-206 was significantly decreased both in rat I/R group and H9c2 cells subjected to hypoxia/reoxygenation (H/R) compared with the corresponding control. Overexpression of miR-206 observably decreased infarct size and inhibited the cardiomyocyte apoptosis induced by I/R injury. Furthermore, bioinformatics analysis, luciferase activity and western blot assay proved that Gadd45beta (growth arrest DNA damage-inducible gene 45beta) was a direct target gene of miR-206. In addition, the expression of pro-apoptotic-related genes, such as p53, Bax and cleaved caspase3, was decreased in association with the down-regulation of Gadd45beta. In summary, this study demonstrates that miR-206 could protect against myocardial I/R injury by targeting Gadd45beta.