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Qing Guo,Zhenlei Chen,Yao Yan,Wenying Xiong,Dan Jiang,Yan Shi 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.2
Lower limb exoskeleton is a typical wearable robot to assist human motion and improve physiological power. However, the control performance and stability are affected by some unknown model parameters and control algorithms. Therefore, it is necessary to investigate the model parametric identification and the control design of lower extremity exoskeleton. Firstly, the two degree-of-freedom (DoF) exoskeleton model is constructed by the Lagrange technique. Then the biogeography-based learning particle swarm optimization (BLPSO) is used to optimize the B-spline function parameters and the smooth stimulated trajectories is designed. Meanwhile, the BLPSO is also adopted to identify unknown model parameters of the exoskeleton based on the torques and the joint angles. To decline the negative effect of parametric identification error of exoskeleton, the passive backstepping controller is proposed to improve the tracking performance of human-robot motion. Furthermore, the active admittance controller is adopted to improve the motion comfort of tester. Finally, the comparative experimental results are verified on the platform, which show the BLPSO algorithm has better parametric identification accuracy than PSO and GA. Furthermore, the comparative results have verified that the proposed controller can improve the tracking behavior and reduce the human-robot interaction torque in wearable motion.
Qing-Li Yang,Ji-Qing Shen,Yan Xue,Xiao-Bing Cheng,Zhi-Hua Jiang,Yi-Chao Yang,Ying-Dan Chen,Xiao-Nong Zhou 대한기생충학열대의학회 2015 The Korean Journal of Parasitology Vol.53 No.6
The nitric oxide (NO) formation and intrinsic nitrosation may be involved in the possible mechanisms of liver fluke-associated carcinogenesis. We still do not know much about the responses of inducible NO synthase (iNOS) induced by Clonorchis sinensis infection. This study was conducted to explore the pathological lesions and iNOS expressions in the liver of mice with different infection intensity levels of C. sinensis. Extensive periductal inflammatory cell infiltration, bile duct hyperplasia, and fibrosis were commonly observed during the infection. The different pathological responses in liver tissues strongly correlated with the infection intensity of C. sinensis. Massive acute spotty necrosis occurred in the liver parenchyma after a severe infection. The iNOS activity in liver tissues increased, and iNOS-expressing cells with morphological differences were observed after a moderate or severe infection. The iNOS-expressing cells in liver tissues had multiple origins.
Fibulin2: a negative regulator of BMSC osteogenic differentiation in infected bone fracture healing
Li Shi-Dan,Xing Wei,Wang Shao-Chuan,Li You-Bin,Jiang Hao,Zheng Han-Xuan,Li Xiao-Ming,Yang Jing,Guo De-Bin,Xie Xiao-Yu,Jiang Ren-Qing,Fan Chao,Li Lei,Xu Xiang,Fei Jun 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Bone fracture remains a common occurrence, with a population-weighted incidence of approximately 3.21 per 1000. In addition, approximately 2% to 50% of patients with skeletal fractures will develop an infection, one of the causes of disordered bone healing. Dysfunction of bone marrow mesenchymal stem cells (BMSCs) plays a key role in disordered bone repair. However, the specific mechanisms underlying BMSC dysfunction caused by bone infection are largely unknown. In this study, we discovered that Fibulin2 expression was upregulated in infected bone tissues and that BMSCs were the source of infection-induced Fibulin2. Importantly, Fibulin2 knockout accelerated mineralized bone formation during skeletal development and inhibited inflammatory bone resorption. We demonstrated that Fibulin2 suppressed BMSC osteogenic differentiation by binding to Notch2 and inactivating the Notch2 signaling pathway. Moreover, Fibulin2 knockdown restored Notch2 pathway activation and promoted BMSC osteogenesis; these outcomes were abolished by DAPT, a Notch inhibitor. Furthermore, transplanted Fibulin2 knockdown BMSCs displayed better bone repair potential in vivo. Altogether, Fibulin2 is a negative regulator of BMSC osteogenic differentiation that inhibits osteogenesis by inactivating the Notch2 signaling pathway in infected bone.
Betulin induces reactive oxygen species-dependent apoptosis in human gastric cancer SGC7901 cells
Yang Li,Xiaokang Liu,Dan Jiang,Yingjia Lin,Yushi Wang,Qing Li,Linlin Liu,Ying-Hua Jin 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.9
Betulin, an abundant natural compound, significantly inhibited the cell viability of advanced human gastric cancer SGC7901 cells. Mechanism study demonstrated that betulin induced apoptosis through mitochondrial Bax and Bak accumulation-mediated intrinsic apoptosis pathway. Downregulation of the anti-apoptosis proteins Bcl-2 and XIAP was involved during betulin-induced cell apoptosis. Reactive oxygen species (ROS) was generated in cells after betulin treatment in a time- and dose-dependent manner. Addition of antioxidant N-acetyl-L-cysteine (NAC) significantly attenuated betulin-induced ROS generation as well as Bcl-2 and XIAP downregulation. The mitochondrial accumulation of Bax and Bak, as well as caspase activity, was also remarkably inhibited by NAC treatment, indicating that ROS are important signaling intermediates that lead to betulin-induced apoptosis by modulating multiple apoptosis-regulating proteins in SGC7901 cells.
Zheng, Hao,Zhang, Qing,Kim, Seung-Joo,Jiang, Xueya,Dan, Meiyu,Gao, Hong,Li, Shengbiao,Wang, Shiquan,Feng, Chuanqi American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.4
<P>KMn8O16 nanorods were prepared through a facile hydrothermal method by using KMnO4 and MnSO4 as reactants. The KMn8O16 samples synthesized at different temperatures (100-160 degrees C) were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), and its electrochemical properties were tested by galvanostatic charge/discharge system. The effect of reaction temperature on the morphology and electrochemical properties was investigated. As electrode materials for the lithium ion battery cycled between 1.5 and 4.2 V, the KMn8O16 nanorods synthesized at 160 degrees C show the highest reversible discharge capacity (160.1 mA h/g even after 50 cycles at current density of 50 mA/g) and the best cycling stability. These results indicate that the KMn8O16 nanorods could be a promising cathode material for lithium ion batteries.</P>
Vitamin D Supplementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis
Liyao Song,Xiaomei Luo,Qing Jiang,Zhi Chen,Lifang Zhou,Dan Wang,Ai Chen 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.2
Objective: We conducted a meta-analysis of randomized controlled trials to explore whether vitamin D supplementation is beneficial for symptom improvement in children with autism spectrum disorder. Methods: We systematically searched the PubMed database, EMBASE, Cochrane Library, Web of Science, Sino-Med, Wanfang Data, and China National Knowledge Infrastructure mainly up to September 2019. Using a fixed effects model, we calculated the standard mean difference with 95% confidence interval. Furthermore, we analyzed baseline serum 25-hydroxyvitamin D levels and outcome scores including the Social Responsiveness Scale and Child Autism Rating Scale scores after vitamin D supplementation. Results: There was no significant difference in baseline serum 25-hydroxyvitamin D levels among 203 children included from three studies in the meta-analysis. After vitamin D supplementation, the outcome scores in the experimental group were dramatically elevated compared with those in the control group (p = 0.03). Conclusion: Vitamin D supplementation improves the typical symptoms of autism spectrum disorder, as indicated by reduced Social Responsiveness Scale and Child Autism Rating Scale scores; thus, it is beneficial for children with autism spectrum disorder.
Photocatalytic removal of methyl orange in an aqueous solution by a WO3/TiO2 composite film
Jian He,Qi Zhou Cai,Qiang Luo,Dan Qing Zhang,Teng Teng Tang,You Fang Jiang 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.2
WO3/TiO2 composite film was prepared by microarc oxidation technique and characterized by SEM, XRD,UV-vis spectra and Zeta-potential. The photocatalytic activity of WO3/TiO2 composite film was evaluated by examining the degradation of methyl orange. The influence of solution pH and inorganic anions on removal ratio of methyl orange was investigated. Removal ratio of methyl orange decreased with an increase of pH value in acidic solution, while it increased with the pH value in alkaline solution. The influence of added anions on the removal ratio is divided into two aspects. Addition of Cl− and SO42− resulted in a decrease in photocatalytic removal ratio of methyl orange, while it was facilitated by PO43−, HCO3− and NO3−.