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Dan Xiao,Kaisen Huang,Qingyong Chen,Baotao Huang,Wei Liu,Yong Peng,Mao Chen,Dejia Huang,Tong Zou,Jiefu Yang 한국유전학회 2015 Genes & Genomics Vol.37 No.7
Apolipoprotein B plays a central role in lipoprotein metabolism. Many studies have evaluated the association between Apolipoprotein B gene polymorphisms (XbaI, EcoRI, SpIns/Del, MspI) and the risk for coronary artery disease and myocardial infarction. However, the results remain inconsistent, particularly among different populations. To more precisely determine the association between Apolipoprotein B gene polymorphisms and coronary artery disease/myocardial infarction risk, we performed a meta-analysis via a comprehensive search of electronic databases (up to February 1st, 2015), odds ratios (OR) and 95 % confidence intervals were calculated using a fixed or random effect model. A total of 47 studies, with 9411 coronary artery disease/myocardial infarction cases and 9082 controls, were included in this meta-analysis. The combined results revealed significant associations between an increased risk of coronary artery disease/myocardial infarction and EcoRI (AA vs GG: OR 1.511, 95 % confidence interval (CI) 1.098, 2.078) and SpIns/Del (DD vs II: OR 1.331, 95 % CI 1.064, 1.665) alleles in the general population. In a subgroup analysis stratified by ethnicity, the T allele of the XbaI variant was associated with a decreased risk in Caucasians, whereas it was associated with an increased risk among the East Asian population. No significant correlation was detected between the A allele of the MspI variant and the coronary artery disease/myocardial infarction risk in either the general population or any ethnic subgroup. The results of our study suggest that Apolipoprotein B gene polymorphisms may affect the coronary artery disease/myocardial infarction susceptibility and these effects may display notable discrepancies among different populations.
A New Unsymmetrical Zinc Phthalocyanine as Photosensitizers for Dye-sensitized Solar Cells
Dan Zhang,Xue-Jun Zhang,Lei Zhang,Li-Jun Mao 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.4
A new unsymmetrical zinc phthalocyanine has been designed and synthesized based on the ‘push-pull’ and extended π-conjugation concept for the dye-sensitized solar cells. Three tert-butoxy groups, which act as electron releasing (‘push’), enhance the solubility of phthalocyanine in common organic solvents and reduce the aggregation. Hydroxy substituted 9,10-anthraquinones act as electron acceptors (‘pull’) for the study of photoinduced electron transfer processes as well as grafting onto nanocrystalline TiO2. The new unsymmetrical zinc phthalocyanine was fully characterized by FTIR, UV-vis, 1H NMR, cyclic voltammetry and differential pulse voltammetry. The new sensitizer was tested in dye-sensitized solar cells, and gave a better performance.
A New Unsymmetrical Zinc Phthalocyanine as Photosensitizers for Dye-sensitized Solar Cells
Zhang, Dan,Zhang, Xue-Jun,Zhang, Lei,Mao, Li-Jun Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.4
A new unsymmetrical zinc phthalocyanine has been designed and synthesized based on the 'push-pull' and extended ${\pi}$-conjugation concept for the dye-sensitized solar cells. Three tert-butoxy groups, which act as electron releasing ('push'), enhance the solubility of phthalocyanine in common organic solvents and reduce the aggregation. Hydroxy substituted 9,10-anthraquinones act as electron acceptors ('pull') for the study of photoinduced electron transfer processes as well as grafting onto nanocrystalline $TiO_2$. The new unsymmetrical zinc phthalocyanine was fully characterized by FTIR, UV-vis, $^1H$ NMR, cyclic voltammetry and differential pulse voltammetry. The new sensitizer was tested in dye-sensitized solar cells, and gave a better performance.
Wang Chao,Mao Xia,Zhao Dan,Yu Hongqiang,Duo Hu,Sun E.,Lu Yuan,Zuo Cunwu 한국식물생명공학회 2022 Plant biotechnology reports Vol.16 No.5
The necrotrophic pathogen Valsa mali (Vm) resulting Valsa canker of apple is considered one of the most destructing fungal diseases. To study the resistance mechanism, we investigated gene expression profiles of suspension cells from resistant varieties ‘Dongbeishanjingzi’ (DS, Malus baccata) and susceptible varieties ‘Gala’ (GL, Malus × domestica) in response to Vm metabolism (VmM) using RNA sequencing (RNA-seq). Functional enrichment showed that differentially expressed genes (DEGs) were widely involved in multiple metabolisms or signals, such as “Lipid metabolic process”, “plant hormone signal transduction” and “plant-pathogen interaction”. Further expressional patterns exhibited that induction of genes related to ‘‘xyloglucan biosynthetic process’’ and ‘‘cell wall biogenesis’’ was beneficial for cell wall integrity and tolerance of DS cells. In brassinosteroid signaling, we identified that TCH4 gene MbTCH4-1 positively regulated Vm resistance of ‘Fuji’ fruit, but BSK gene MdBSK1 negatively regulated the resistance. In contrast, cell death associated with hypersensitive response caused by up-regulation of CNGCs and CDPK genes is an important cause of weakened tolerance in GL cells. Our results provide a new insight direction for the molecular mechanism of apple against Valsa canker.
Analysis of the Internal Electrical Characteristics of Electronic Power Transformers
Yi, Yang,Mao, Cheng-Xiong,Wang, Dan,Lu, Ji-Ming The Korean Institute of Power Electronics 2013 JOURNAL OF POWER ELECTRONICS Vol.13 No.5
The modularized subunit of an electronic power transformer (EPT) is a series connection of two H-bridge voltage-source converters and a DC-DC converter with a high-frequency isolation transformer (HFIT). On the basis of cascading and paralleling the modularized subunits, EPT can be used in high-voltage and large-current applications in the power system. This paper discusses the steady state analysis of the modularized subunit of EPT. Theoretical analysis considers the influences of the two H-bridge voltage-source converters on the two sides of the DC-DC converter. We deduce the formulas of the theoretical calculation on the internal electrical characteristics of EPT (e.g., the voltages of the DC-bus capacitor and the primary side peak current of the HFIT). This paper provides guidance on the design and selection of EPT key elements (e.g., the DC-bus capacitors and HFIT). Experimental results are obtained from a single subunit of a laboratory model rated at 962 V, 15 kVA. All calculations, simulations, and experiments confirm the theoretical analysis of the subunit of EPT.
Jia-Wei Lv,Xiao-Dan Huang,Yu-Pei Chen,Guan-Qun Zhou,Ling-Long Tang,Yan-Ping Mao,Wen-Fei Li,Ai-Hua Lin,Jun Ma,Ying Sun 대한암학회 2018 Cancer Research and Treatment Vol.50 No.2
Purpose Conditional survival (CS) provides important information on survival for a period of time after diagnosis. Currently, information on CS patterns of patients with nasopharyngeal carcinoma (NPC) is lacking. We aimed to analyze survival rate over time and estimate CS for NPC patients using a national population-based registry. Materials and Methods Patients diagnosed with NPC between 1973 and 2007 with at least 5-year follow-up were identified from the Surveillance Epidemiology End Results registry. Traditional survival rates and crude CS estimates were calculated using Kaplan-Meier analysis. Risk-adjusted survival curves were plotted from the proportional hazards model using the correct group prognosis method. Results For 7,713 patients analyzed, adjusted baseline 5-year overall survival improved significantly from 36.0% in patients diagnosed in 1973-1979, 41.7% in 1980-1989, 46.6% in 1990- 1999, to 54.7% in 2000-2007 (p < 0.01). CS analysis demonstrated that for every additional year survived, adjusted probability of surviving the next 5 years increased from 66.7% (localized), 54.0% (regional), and 35.3% (distant) at the time of diagnosis, to 83.7% (localized), 75.0% (regional), and 62.2% (distant) for patients who had survived 5 years. Adjusted 5-year CS differed among age, sex, tumor histology, ethnicity, and stage subgroups initially, but converged with time. Conclusion Treatment outcomes of NPC patients have greatly improved over the decades. Increases in CS become more prominent in patients with distant disease than in those with localized or regional disease as patients survive longer. CS provides more dynamic prognostic information for patients who have survived a period of time after diagnosis.
Wei, Tianliu,Wang, Qiuyuan,Mao, Chengxiong,Lu, Jiming,Wang, Dan The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.6
This paper analyses the harmonic pollution to power grids caused by thyristor-controlled devices. It also formulates a mathematic derivation for the voltage spikes in thyristor-controlled branches to explain the harmonic and EMI derived from the reverse-recovery characteristics of the thyristor. With an equivalent nonlinear time-varying voltage source, a detailed simulation model is established, and the periodic dynamic switching characteristic of the thyristor can be explicitly implied. The simulation results are consistent with the probed results from on-site measurements. An improved trigger system with gate-shorted circuit structure is proposed to reduce the voltage spikes that cause EMI. The experimental results indicate that a prototype with the improved trigger system can effectively suppress the voltage spikes.
Gene expression profile of NFκB repressing factor(NKRF) knockdown cells by microarray analysis
Sun Yaqiong,Zheng Dan,Gu Shaohua,Mao Yumin,Xie Yi 한국바이오칩학회 2012 BioChip Journal Vol.6 No.3
Human NFκB repressing factor(NKRF) is a negative regulation transcription factor, which is able to repress transcription by binding to the negative regulatory element(NRE) near the NFκB binding site in certain genes’ promoters. Current researches reveals that NKRF represses the activation of IFN-β, IL-8,hiNOS and HIV-1 by NFκB. We used optical fiber beadchip to analysis the different gene expression patterns of RNAi mediated NKRF knockdown HEK293 cells and found that several genes showed significant change of expression levels. Real-time PCR was performed to verify the changes of expression of candidate genes. We analyzed the function of candidate genes by searching the gene ontology databases and publications and revealed that these genes functioned in cell cycle, cell proliferation, apoptosis, cell migration, DNA repair, transcription, metabolism, response to stimulus and signal transduction. This study provides new perspectives on NKRF’s potential multiple functions.