http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effect of Refractory Properties on Initial Bubble Formation in Continuous-Casting Nozzles
이고기,Brian G. Thomas,김선효 대한금속·재료학회 2010 METALS AND MATERIALS International Vol.16 No.3
A water model has been applied to investigate initial bubble behavior using specially-coated samples of porous MgO refractory to simulate the high-contact angle of steel-argon refractory systems with different permeabilities. Air is injected through the porous refractory and travels through many inter-connected pores to exit the surface through “active sites”. An active site is a pore where bubbles exit from the surface of the porous refractory. The effect of refractory properties has been investigated in both stagnant and downward-flowing water. The number of active sites increases with increasing gas injection flow rate, permeability, and velocity of the downward-flowing water, and lower contact angle.
Postoperative Low-Dose Tranexamic Acid After Major Spine Surgery: A Matched Cohort Analysis
Lauren K. Dunn,Ching-Jen Chen,Davis G. Taylor,Kamilla Esfahani,Brian Brenner,Charles Luo,Thomas J. Buell,Sarah N. Spangler,Avery L. Buchholz,Justin S. Smith,Christopher I. Shaffrey,Edward C. Nemergut 대한척추신경외과학회 2020 Neurospine Vol.17 No.4
Objective: This was a retrospective, cohort study investigating the efficacy and safety of continuous low-dose postoperative tranexamic acid (PTXA) on drain output and transfusion requirements following adult spinal deformity surgery. Methods: One hundred forty-seven patients undergoing posterior instrumented thoracolumbar fusion of ≥3 vertebral levels at a single institution who received low-dose PTXA infusion (0.5–1 mg/kg/hr) for 24 hours were compared to 292 control patients who did not receive PTXA. The cohorts were propensity matched based on age, sex, American Society of Anesthesiologist physical status classification, body mass index, number of surgical levels, revision surgery, operative duration, and total intraoperative TXA dose (n=106 in each group). Primary outcome was 72-hour postoperative drain output. Secondary outcomes were number of allogeneic blood transfusions. Results: There was no significant difference in postoperative drain output in the PTXA group compared to control (660±420 mL vs. 710±490 mL, p=0.46). The PTXA group received significantly more crystalloid (6,100±3,100 mL vs. 4,600±2,400 mL, p<0.001) and red blood cell transfusions postoperatively (median [interquartile range]: 1 [0–2] units vs. 0 [0–1] units; incidence rate ratio [95% confidence interval], 1.6 [1.2–2.2]; p=0.001). Rates of adverse events were comparable between groups. Conclusion: Continuous low-dose PTXA infusion was not associated with reduced drain output after spinal deformity surgery. No difference in thromboembolic incidence was observed. A prospective dose escalation study is warranted to investigate the efficacy of higher dose PTXA.
Marcus A. Florez(Marcus A. Florez ),Brian De(Brian De ),Bhavana V. Chapman(Bhavana V. Chapman ),Anussara Prayongrat(Anussara Prayongrat ),Jonathan G. Thomas(Jonathan G. Thomas ),Thomas H. Beckham(Thom 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.1
Purpose: There has been limited work assessing the use of re-irradiation (re-RT) for local failure following stereotactic spinal radiosurgery (SSRS). We reviewed our institutional experience of conventionally-fractionated external beam radiation (cEBRT) for salvage therapy following SSRS local failure. Materials and Methods: We performed a retrospective review of 54 patients that underwent salvage conventional re-RT at previously SSRS-treated sites. Local control following re-RT was defined as the absence of progression at the treated site as determined by magnetic resonance imaging. Results: Competing risk analysis for local failure was performed using a Fine-Gray model. The median follow-up time was 25 months and median overall survival (OS) was 16 months (95% confidence interval [CI], 10.8–24.9 months) following cEBRT re-RT. Multivariable Cox proportional-hazards analysis revealed Karnofsky performance score prior to re-RT (hazard ratio [HR] = 0.95; 95% CI, 0.93– 0.98; p = 0.003) and time to local failure (HR = 0.97; 95% CI, 0.94–1.00; p = 0.04) were associated with longer OS, while male sex (HR = 3.92; 95% CI, 1.64–9.33; p = 0.002) was associated with shorter OS. Local control at 12 months was 81% (95% CI, 69.3–94.0). Competing risk multivariable regression revealed radioresistant tumors (subhazard ratio [subHR] = 0.36; 95% CI, 0.15–0.90; p = 0.028) and epidural disease (subHR = 0.31; 95% CI, 0.12–0.78; p =0.013) were associated with increased risk of local failure. At 12 months, 91% of patients maintained ambulatory function. Conclusion: Our data suggest that cEBRT following SSRS local failure can be used safely and effectively. Further investigation is needed into optimal patient selection for cEBRT in the retreatment setting.