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Hwangbo, Bin,Kim, Seok Ki,Lee, Hee-Seok,Lee, Hyun Sung,Kim, Moon Soo,Lee, Jong Mog,Kim, Hyae-Young,Lee, Geon-Kook,Nam, Byung-Ho,Zo, Jae Ill Elsevier 2009 Chest Vol.135 No.5
<P>BACKGROUND: The role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) following integrated PET/CT scanning in mediastinal staging of non-small cell lung cancer (NSCLC) has not been assessed. METHODS: We prospectively evaluated the diagnostic values of PET/CT scanning and EBUS-TBNA for mediastinal staging in 117 patients with potentially operable NSCLC with accessible mediastinal lymph nodes (diameter range, 5 to 20 mm) by EBUS-TBNA. Subgroup analysis according to histologic type was performed. RESULTS: Of 30 cases of mediastinal metastasis, 27 were confirmed by EBUS-TBNA and 3 were confirmed by surgery. EBUS-TBNA results confirmed all cases with true-positive PET/CT scan findings and six of nine cases with false-negative PET/CT scan findings. The sensitivity, specificity, positive predictive value, negative predictive value (NPV), and accuracy of EBUS-TBNA in the detection of mediastinal metastasis were 90.0%, 100%, 100%, 96.7%, and 97.4%, respectively. For PET/CT scans, the values were 70.0%, 59.8%, 37.5%, 85.2%, and 62.4%, respectively (p = 0.052; p < 0.001; p < 0.001; p = 0.011; p < 0.001, respectively). In adenocarcinoma (n = 55), EBUS-TBNA detected four of six cases with false-negative PET/CT scan findings, and the NPV was higher for EBUS-TBNA than for PET/CT scans (94.6% vs 77.8%, respectively; p = 0.044). In squamous cell carcinoma (n = 53), the NPV of EBUS-TBNA and PET/CT scans were similarly high (97.9% vs 96.3%, respectively; p = 0.689). CONCLUSIONS: EBUS-TBNA was an effective invasive method following PET/CT scanning in the mediastinal staging of potentially operable NSCLC. In mediastinal PET/CT scan-positive cases, EBUS-TBNA was an excellent tool for detecting mediastinal metastasis. Even in mediastinal PET/CT scan-negative cases, EBUS-TBNA can be useful for confirming mediastinal metastases, especially in adenocarcinoma.</P>
Transoesophageal needle aspiration using a convex probe ultrasonic bronchoscope
HWANGBO, Bin,LEE, Hee Seok,LEE, Geon-Kook,LIM, Kun-Young,LEE, Soo-Hyun,KIM, Hyae-Young,LEE, Jong-Yeul,ZO, Jae Ill Blackwell Publishing Asia 2009 Respirology Vol.14 No.6
<P>ABSTRACT</P><P>Background and objective: </P><P>Although endoscopic ultrasound-guided fine needle aspiration can be helpful when combined with bronchoscopic procedures, endoscopic ultrasound-guided fine needle aspiration is not available as a conjunctive procedure with bronchoscopy at many institutions. This study evaluated the feasibility and the additional role of transoesophageal fine needle aspiration using a convex probe ultrasonic bronchoscope (EUS-B-FNA).</P><P>Methods: </P><P>We analysed 84 patients who underwent EUS-B-FNA between Oct 2007 and May 2008. Bronchoscopy and/or endobronchial ultrasound-guided transbronchial needle aspiration was performed on 83 patients prior to EUS-B-FNA.</P><P>Results: </P><P>EUS-B-FNA was performed on 89 lesions (1.7 aspirations/lesion) including three lung masses and 86 lymph nodes (nodal stations 1, 3P, 4L, 5, 7, 8, 9 and 10L) without complication. Sample adequacy was 95.4% for each aspiration and 100% for each lesion. Of the 89 lesions, 39 malignant lesions were confirmed by EUS-B-FNA. EUS-B-FNA provided additional diagnostic gain to bronchoscopic procedures in 16 patients (19.0%): 3 lung cancers were upstaged, 11 lung cancers were pathologically confirmed, and 2 patients were diagnosed with mediastinal metastasis from an extrathoracic malignancy. This gain was obtained by the sampling of inaccessible (<I>n</I> = 4) or difficult lesions by endobronchial ultrasound-guided transbronchial needle aspiration (<I>n</I> = 2) or when bronchoscopy was difficult due to dyspnoea, cough, brain metastasis or other conditions (<I>n</I> = 10).</P><P>Conclusions: </P><P>EUS-B-FNA is a technically feasible and safe procedure, which may be an alternative to endoscopic ultrasound-guided fine needle aspiration as a procedure that complements bronchoscopy. Additional diagnostic yield can be obtained by combining EUS-B-FNA with bronchoscopic procedures.</P>
폐렴구균 균혈증에서 폐렴구균의 페니실린 내성 여부가 사망률에 미치는 영향
황보빈 ( Bin Hwangbo ),윤호일 ( Ho Il Yoon ),이상민 ( Sang Min Lee ),최승호 ( Seung Ho Choi ),박계영 ( Gye Young Park ),유철규 ( Chul Gyu Yoo ),이춘택 ( Choon Taek Lee ),김영환 ( Young Whan Kim ),한성구 ( Sung Koo Han ),민경업 ( K 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.47 No.2
Endobronchial Ultrasound Guided Transbronchial Needle Aspiration의 임상적 유용성
황보빈,HwangBo, Bin 대한기관식도과학회 2008 大韓氣管食道科學會誌 Vol.14 No.2
Endobronchial ultrasound guided transbronchial needle aspiration is a recently introduceddiagnostic method which enables real time aspiration of peritracheal and peribronchial lesions. The high sensitivity and the high diagnostic accuracy of EBUS-TBNA in the mediastinal staging of lung cancer have been reported. EBUS-TBNA also showed the high diagnostic yield in the diagnosis of lung parenchymal masses adjacent to the trachea or the large airways. EBUS-TBNA is a good diagnostic method for mediastinal diseases, such as sarcoidosis. Until now, no major complications of EBUS-TBNA have been reported. EBUS-TBNA should be considered for the mediastinal staging of lung cancer and the diagnosis of mediastinal lymphadenopathies.
S-614 A case of intracavitary pulmonary aspergillosis treated with instillation of voriconaz ole
( Hyein Lee ),( Bin Hwangbo ),( Hyojae Kang ),( Joohae Kim ),( Young Ju Choi ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Medical Treatment of symptomatic intracavitary pulmonary aspergillosis is difficult. Oral or intravenous anti-fungal agents have limited roles. Bronchial artery embolization or surgery is considered for intractable hemoptysis. Intracavitary instillation of amphotericin B through the per cutaneous catheter has been attempted for pulmonary aspergillosis with hemoptysis, showing favorable short-term outcome. We experienced a case of a 69-year-old man with chronic infection of aspergillosis in a huge right upper lobe cavity which was developed after endobronchial brachy-therapy. The patient complained chronic cough and cheat pain. Treatment with systemic voriconalzole and bronchoscopic intracavitary instillation of amphotericin B was failed. Fungal colonies were disappeared after treatment with instillation of voriconazole through fiberoptic bronchoscopy. This is the first case report of intacavitary aspergillosis treated with bronchospcic instillation of voriconazole.
열 사이클(Thermal cycle) 하에서 그래핀(Graphene) 박막의 기계적 거동
황보윤(Yun Hwangbo),현승민(Seungmin Hyun),이학주(Hak-Joo Lee),이영빈(Young-Bin Lee),안종현(Jong-Hyun Ahn) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
As a new material, graphene is expected to be a promising material for various applications. The study of its basic property in graphene is now being carried out by many research groups in the whole world. On the other hand, a study of graphene film fabricated by chemical vapor deposition (CVD) method is still more needed. This paper presents the mechanical and electrical behavior of graphene film under thermal cycle conditions. Graphene film was transferred on silicon nitride (SiN<SUB>x</SUB>) membrane and to evaluate residual stress of graphene film, the resonance system was used. The system derives graphene film electrostatically and detects the continuous change of resonant frequency under thermal cycles. Residual stress due to the difference in thermal expansion coefficient between SiNx and graphene was obtained from the resonant frequency. Simultaneously, the variation of resistance in graphene film was also measured to assess electrical behavior under thermal cycle.
( Jungeun Bae ),( Hwangbo Song ),( Bongjin Moon ),( Han Bin Oh ) 한국질량분석학회 2016 Mass spectrometry letters Vol.7 No.4
To determine the influence of the cationization agent on the collision activated dissociation (CAD) fragmentation behavior of oligosaccharides, the CAD spectra of the singly protonated, sodiated oligosaccharides and singly sodiated and dibenzo-18-crown-6 ether conjugated oligosaccharides were carefully compared. Each of these three different species showed quite different fragmentation spectra. The comparison of singly protonated and sodiated oligosaccharide CAD spectra revealed that different cationization agents affected the cationization agent adduction sites as well as the fragmentation sites within the oligosaccharides. When the mobility of Na<sup>+</sup> was limited by the dibenzo-18-crown-6 ether encapsulation agent, the examined linear oligosaccharides showed fragmentation patterns quite different from the unmodified ones. For the dibenzo-18-crown-6 ether conjugated oligosaccharides, the charge-remote fragmentation pathways were more likely to be activated than the chargedirected pathways. This work demonstrates that dibenzo-18-crown-6 ether conjugation can potentially provide a route to selectively activate the charge-remote fragmentation pathways, albeit to a limited extent, in tandem mass spectrometry studies.