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Prognostic Significance of the Mucin Component in Stage III Rectal Carcinoma Patients
Wang, Meng,Zhang, Yuan-Chuan,Yang, Xu-Yang,Wang, Zi-Qiang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19
Background: Although mucinous adenocarcinoma has been recognized for a long time, whether it is associated with a poorer prognosis in colorectal cancer patients is still controversial. Many studies put emphasis on mucinous adenocarcinoma containing mucin component ${\geq}50%$. Only a few studies have analyzed cases with a mucin component <50%. Objectives: This study aimed to analyze the prognostic value of different mucin component proportions in patients with stage III rectal cancer. Materials and Methods: Clinical, pathological and follow-up data of 136 patients with the stage III rectal cancer were collected. Every variable was analyzed by univariate analysis, then multivariate analysis and survival analysis were further performed. Results: Univariate analysis showed pathologic T stage, lymphovascular invasion, and histological subtype were statistically significant for DFS. Pathologic T stage was significant for OS. Histological subtype and lymphovascular invasion were independent prognostic factors in multivariate analysis for DFS, and histological subtype was the only independent prognostic factor for OS. Survival curves showed the survival time of mucinous adenocarcinoma (MUC) was shorter than non-MUC (adenocarcinomas with a mucin component <50% and without mucin component). Conclusions: Histological subtype (tumor with different mucin component) was an independent prognostic factor for both DFS and OS. Patients with MUC had a worse prognosis than their non-MUC counterparts with stage III rectal carcinoma.
류현열,이창규,최재호 고신대학교 의학부 2000 高神大學校 醫學部 論文集 Vol.15 No.1
Background Tumor growth and metastasis require angiogenesis. Microvessel density (MVD), a measure of tumor angiogenesis, correlates with metastasis in man cancers, but its importance has not been evaluated in renal cell carcinoma with varying clinical behavior and prognosis. Methods To evaluate the prognostic significance of MVD in renal cell carcinoma, the relationship of MVD to tumor stage, histologic type, tumor grade and metastasis was studied in a retrospective review of 57 patients with renal cell carcinoma from January 1990 to December 1994. MVD was evaluated immunohistochemically using the labeled streptavidin-biotin-peroxidase method with monoclonal antibody directed against factor Ⅷ-related antigen. The area of highest MVD within the tumor was selected for review without knowledge of the patient's clinical parameters, and the number of vessels in an x400 field (0.1855mm^(2)) was counted. Results Mean was 597±173 vessels/mm^(2) and mean follow-up was 3.5 years. The mean MVD in 20 patients (35%) with metastasis was 635±202 vessels/mm^(2) and mean MVD in 37 patients (65%) without metastasis was significantly lower, 500±128 vessels/mm^(2) (P=0.024). MVD increased with increasing tumor grade, but no statistically significant differences. Conclusions MVD in renal cell carcinoma was significantly correlated with metastasis and MVD has a clinically practical and significant value in prognosis.
류현열,이창규,최재호 고신대학교(의대) 고신대학교 의과대학 학술지 2000 고신대학교 의과대학 학술지 Vol.15 No.1
Background : Tumor growth and metastasis require angiogenesis. Microvessel density (MVD), a measure of tumor angiogenesis, correlates with metastasis in man cancers, but its importance has not been evaluated in renal cell carcinoma with varying clinical behavior and prognosis. Methods : To evaluate the prognostic significance of MVD in renal cell carcinoma, the relationship of MVD to tumor stage, histologic type, tumor grade and metastasis was studied in a retrospective review of 57 patients with renal cell carcinoma from January 1990 to December 1994. MVD was evaluated immunohistochemically using the labeled streptavidin-biotin-peroxidase method with monoclonal antibody directed against factor 8-related antigen. The area of highest vessels in an x400 field (0.1855mm2) was counted. Results : Mean was 597±173 vessels/mm2 and mean MVD in 37 patients (65%) without metastasis was significantly lower, 500±128 vessels/mm2 (P=0.024). MVD increased with increasing tumor grade, but no statistically significant differences. Conclusions : MVD in renal cell carcinoma was significantly correlated with metastasis and MVD has a clinically practical and significant value in prognosis.
The Prognostic Significance of Patient-Prosthesis Mismatch after Aortic Valve Replacement
Paolo Nardi,Marco Russo,Guglielmo Saitto,Giovanni Ruvolo 대한흉부외과학회 2018 Journal of Chest Surgery (J Chest Surg) Vol.51 No.3
Patient-prosthesis mismatch (PPM) is a controversial issue in current clinical practice. PPM has been reported to have a negative impact on patients’ prognosis after aortic valve replacement in several studies, showing increased all-cause and cardiac mortality. Moreover, a close relationship has recently been described between PPM and structural valve deterioration in biological prostheses. In patients at risk for PPM, several issues should be considered, and in the current era of cardiac surgery, preoperative planning should consider the different types of valves available and the various surgical techniques that can be used to prevent PPM. The present paper analyses the state of the art of the PPM issue.
Somatic Mutations of K-Ras and BRAF in Thai Colorectal Cancer and their Prognostic Value
Chaiyapan, Welawee,Duangpakdee, Pongsanae,Boonpipattanapong, Teeranut,Kanngern, Samornmas,Sangkhathat, Surasak Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: The study aimed to determine the incidence of K-ras and BRAF mutations in colorectal cancers (CRCs) in Thai patients and evaluate association with clinicopathological parameters including treatment outcomes in terms of event free survival (EFS). Materials and Methods: Two-hundred colorectal cancer specimens were collected for studies of K-Ras codon 12, 13 and 61, and BRAF codon 600 by polymerase chain reaction and direct nucleotide sequencing. Results: The overall incidence of K-Ras mutations in our patients was 23%. K-ras mutation frequencies in CRC stages (AJCC) I, II, III and IV were 6.7%, 16.1%, 23.3% and 26.6%, respectively (p-value>0.05). The three most common mutation forms were G12D, G12V and G13D. K-Ras mutation status was associated with poorer EFS in stage I-III CRCs (p-value 0.03). Conclusions: The study found a lower mutation frequency of K-Ras and BRAF compared to reports involving other ethnic groups. However, K-Ras mutations did have a negative prognostic value in early-stage CRCs.
Expression of HMGB1 and its Clinical Significance in T-cell Lymphoma
Mao, Xing-Jiang,Wang, Geng-Fu,Chen, Zhi-Jun,Wang, Li-Na,Zhang, Jun-Biao,Wang, Hui-Ling Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
Objectives: To evaluate the clinical significance of HMGB1 expression in T-cell lymphoma. Methods: Immunohistochemical staining for HMGB1 and survivin was performed with specimens from 120 cases of T-cell lymphoma and 40 cases of reactive lymphoid hyperplasia with antibodies against human HMGB1 and survivin. Results: The expression of HMGB1 and survivin was significantly higher in tissues of T-cell lymphoma than in reactive lymphoid hyperplasia. Positive expression of HMGB1 and survivin was observed in 63.7% (65/102) and 61.8% (63/102) of T-cell lymphoma cases, respectively. While was associated with gender, age, and tumor location, significant correlations with malignancy and clinical stage were observed. Spearman rank correlation analysis revealed that the expression of HMGB1 and survivin was positively correlated in T-cell lymphomas (P<0.01). Conclusions: Expression of HMGB1 and survivin in T-cell lymphomas is significantly associated with malignancy and clinical stage, but not with gender, age and tumor location. Elevated expression of HMGB1 may be an important biomarker for the development and progression of T-cell lymphoma.
Nonsrijun, Nongnuch,Mitchai, Jumphol,Brown, Kamoltip,Leksomboon, Ratana,Tuamsuk, Panya Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Background: The incidence of prostate cancer, one of the most common cancers in elderly men, is increasing annually in Thailand. Matrix metalloproteinase 11 (MMP-11) is a member of the extracellular matrix metalloproteases which has been associated with human tumor progression and clinical outcome. Aim: To quantify MMP-11 expression in prostatic adenocarcinoma tissues and to determine whether its overexpression correlates with survival outcome, and to assess its potential as a new prognostic marker. Materials and Methods: Expression of MMP-11 was analyzed using immunohistochemistry in 103 Thai patients with prostatic adenocarcinoma. Overall survival was analyzed using Kaplan-Meier methods and Cox regression models. Results: Immunoreactivity of MMP-11 was seen in the stroma of prostatic adenocarcinoma tissue samples, high expression being significantly correlated with poor differentiation in Gleason grading, pathologic tumor stage 4 (pT4), and positive-bone metastasis (p<0.05), but not age and prostatic-specific antigen (PSA) level. Patients with high levels of MMP-11 expression demonstrated significantly shorter survival (p<0.001) when compared to those with low levels. Multivariate analysis showed that MMP-11 expression and pT stage were related with survival in prostatic adenocarcinoma [hazard ratio (HR)=0.448, 95% confidence interval (95%CI)=0.212-0.946, HR=0.333, 95%CI=0.15-0.74, respectively]. Conclusions: Expression of MMP-11 is significantly associated with survival in prostatic adenocarcinoma. High levels may potentially be used for prediction of a poor prognosis.