이식신 적출술의 적응증 및 술기

류현열,장진호 大韓泌尿器科學會 1993 Korean Journal of Urology Vol.34 No.3

전립선비대증에 대한 임상적 관찰

류현열,장세국 大韓泌尿器科學會 1984 Korean Journal of Urology Vol.25 No.1

Effects of Nitric Oxide on the Induction of Experimental Allergic Orchitis in Guinea Pig

류현열,안종환,김인근,김택상,곽현종,정헌택 대한면역학회 2004 Immune Network Vol.4 No.2

Background: Production of nitric oxide (NO) by inducible NO synthase (iNOS) has been implicated in the pathology of autoimmune disease. It is unknown whether iNOS expression is increased within testes and whether iNOS and NO have essential roles in the pathogenesis of EAO. Methods: EAO was induced in guinea pig testes at 17 days after secondary immunization by administration of crude extract (CE) and purified glycoprotein 1 (GP1) from normal guinea pig testes. iNOS gene expression was assessed by RT-PCR and Northern blot analysis in testes. Localization of iNOS and Mac-1 and the indicator of NO-mediated tissue injury, nitrotyrosine, were detected in the testicular lesion by immunohistochemistry. Results: In control testes, inflammation and iNOS gene expression were not detected, whereas, in CE- and GP1-injected testes, inflammation and marked iNOS gene expression were evident at day 17 after secondary immunization. Immunohistochemistry of Mac-1 showed the colocalization with iNOS protein and nitrotyrosyl proteins in intertubules, suggesting that NO produced by infiltrated macrophages may be involved in inflammatory lesions of intertubules. Intraperitoneal administration of aminoguanidine significantly prevented EAO with reduction of inflammation, iNOS expression and nitrotyrosine formation. Conclusion: These results suggest that NO production by macrophages may be important in the pathogenesis of CE- and GP1-induced EAO. Furthermore, this study demonstrated the therapeutic potential of iNOS inhibitor in the treatment of inflammatory and autoimmune mediated-diseases. (Immune Network 2004;4(2):108-115)

비융합성 교차성 전위신 1례

류현열 고신대학교 의학부 1986 高神大學校 醫學部 論文集 Vol.2 No.1

Crossed renal ectopia is an unusual congenital anomaly, probably produced by abnormal development of the ureteral bud. In crossed renal ectopia without fusion, the kidney lies on the opposite side of the body but is not attaches to its normally placed mate. The deformity itself produces no symptoms and the clinical presentation generally is for obstruction and infection. Unless 2 distinct renal shadows can be seen, it may difficult to differentiate this condition from crossed renal ectopia with fusion. Herein a case of renal ectopia without fusion is reported in a 12 years old girl, with a brief review of literature.

인체신세포암에서 자연살해세포의 활성화

류현열,Eschenbach, Andrew C. von 고신대학교 의학부 1995 高神大學校 醫學部 論文集 Vol.10 No.2

Natural killer (NK) cells that had infilterated renal cell carcinoma(RCC) proliferated vigorously in culture which activated interleukin-2(IL-2) and lysed autologous tumor cells. We studied the susceptibility of RCC cells to NK-cell lysis and their ability to stimulate proliferation and function of NK cells. Cells from primary culture of RCC(p-RCC cells) were significantly more susceptible to lysis mediated by human NK3.3 clones than were cells from primary culture of metastatic melanomas. RCC cells clones was also susceptible to lysis by NK3.3 clones and IL-2 activated peripheral blood lymphocytes(PBLs). Incubation of NK3.3 clones with p-RCC cells in the absence of IL-2 induced proliferation of NK3.3 clones, whereas incubation with cells from primary culture of metastatic melanomas, K562 cells tested did not. The p-RCC cells from earlier passages were more potent inducers of NK-cell proliferation than were those from older passages. Cell-free culture supernatants of p-RCC cells with or without NK3.3 clones failed to induce NK-cell proliferation. Incubation of NK cells purified from PBLs with p-RCC cells induced higher proliferation of the NK cells only in the presence of IL-2, whereas incubation with cells from primary culture of metastatic melanomas did not. In summary, these results suggest that RCC cells are able to activate NK cells, potentially through cell-to-cell interaction.

방사선 치료후 재발성 및 지속성 전립선암에 있어서 냉동수술의 유용성

류현열,이창규 고신대학교 의학부 1996 高神大學校 醫學部 論文集 Vol.11 No.1-2

The optimum management for men failing radiation therapy remains controversial in localized prostatic cancer. Recurrent disease when diagnosed after radiotherapy, is most frequently less differentiated and a higher histologic grade which generally responds less well to androgen ablation. This study is designed to 57 evaluable patients who have histologically proved recurrent or persistent adenocarcinoma of the prostate following definitive radiation therapy. Age of these patients was from 57 to 70 year-old and mean age was 69.6. Mean recurrent duration after radiation was 4.8 years. Gleason grade in pre-primary radiation therapy was mostly 6(12 cases) and above 8 were 3 cases(7%). Gleason grade in pre-cryotherapy was mostly 8(17cases) and above 8 were 25 cases(45%). Complications after cryotherapy were incontinence(42%), and then obstruction symptoms(19%), scrotal edema(14%), gross hematuria(13%), penile pain(12%) were followed. After 3 months of cryotherapy, these compications was markedly decreased. PSA level after cryotherapy was decreased in 69 cases(80%) than pre-cryotherapy. Of these, 45 cases(52%) were decreased in range between 4.0ng/ml to 0.3ng/ml and 20 cases(23%) were decreased below 0.3ng/ml. Prostatic biopsy after 6 months of cryotherapy was done in 44 caese. Of these, 27 cases showed no remnant cancer. In conclusion, cryotherapy for recurrent or persistent localized prostatic cancer following radiation therapy developed no serious complications and decreased PSA level. Also, in prostatic biopsy after 6 months of cryotherapy, no remnant prostatic cancer was 61%. Therefore, we think that cryotherapy is useful in recurrent or persistant localized prostatic cancer following radiation therapy.

신장 평활근종 1례

류현열,이세일,권민아,박윤규,박동춘 大韓泌尿器科學會 1983 Korean Journal of Urology Vol.24 No.2

방사선 치료후 재발성 및 지속성 전립선암에 있어서 냉동수술의 유용성

류현열,이창규 고신대학교(의대) 고신대학교 의과대학 학술지 1996 고신대학교 의과대학 학술지 Vol.11 No.1

-Abstract- The optimum management for men failing radiation therapy remains controversial in localized prostatic cancer. Recurrent disease when diagnosed after radiotherapy, is most frequently less differentiated and a higher histologic grade which generally responds less well to androgen ablation. This study is designed to 57 evaluable patients who have histologically proved recurrent or persistent adenocarcinoma of the prostate following definitive radiation therapy. Age of these patients was from 57 to 70 year-old and mean age was 69.6. Mean recurrent duration after radiation was 4.8 years. Gleason grade in pre-primary radiation therapy was mostly 6 (12 cases) and above 8 were 25 cases (45%). Complications after cryotherapy were incontinence (42%), and then obstruction symptoms (19%), scrotal edema (14%), gross hematuria (13%), penile pain (12%) were followed. After 3 months of cryotherapy, these complications was markedly decreased. PSA level after cryotherapy was decreased in 69 cases (80%) than pre-cryotherapy. Of these, 45 cases (52%) were decreased in range between 4.0ng/ml to 0.3ng/ml and 20 cases (23%) were decreased below 0.3ng/ml. Prostatic biopsy after 6 months of cryotherapy was done in 44 cases. Of these, 27 cases showed no remnant cancer. In conclusion, cryotherapy for recurrent or persistent localized prostatic cancer following radiation therapy developed no serious complications and decreased PSA level. Also, in prostatic biopsy after 6 months of cryotherapy, no remnant prostatic cancer was 61%. Therefore, we think that cryotherapy is useful in recurrent or persistent localized prostatic cancer following radiation therapy.

부산 지역에서의 전립선비대증 유병율에 관한 조사

류현열,구자환,조석수,강주석,이창규,김종철,조문환 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.2

신세포암의 예후인자로서 종양 신생혈관밀도의 의의

류현열,이창규,최재호 고신대학교 의학부 2000 高神大學校 醫學部 論文集 Vol.15 No.1

Background Tumor growth and metastasis require angiogenesis. Microvessel density (MVD), a measure of tumor angiogenesis, correlates with metastasis in man cancers, but its importance has not been evaluated in renal cell carcinoma with varying clinical behavior and prognosis. Methods To evaluate the prognostic significance of MVD in renal cell carcinoma, the relationship of MVD to tumor stage, histologic type, tumor grade and metastasis was studied in a retrospective review of 57 patients with renal cell carcinoma from January 1990 to December 1994. MVD was evaluated immunohistochemically using the labeled streptavidin-biotin-peroxidase method with monoclonal antibody directed against factor Ⅷ-related antigen. The area of highest MVD within the tumor was selected for review without knowledge of the patient's clinical parameters, and the number of vessels in an x400 field (0.1855mm^(2)) was counted. Results Mean was 597±173 vessels/mm^(2) and mean follow-up was 3.5 years. The mean MVD in 20 patients (35%) with metastasis was 635±202 vessels/mm^(2) and mean MVD in 37 patients (65%) without metastasis was significantly lower, 500±128 vessels/mm^(2) (P=0.024). MVD increased with increasing tumor grade, but no statistically significant differences. Conclusions MVD in renal cell carcinoma was significantly correlated with metastasis and MVD has a clinically practical and significant value in prognosis.